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Research Paper On Nal-Patella Syndrome

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Nail-Patella Syndrome: Genetic Basis

Nail Patella syndrome (NPS) is an autosomal dominant disorder. This means that it can get “passed down”. Disorders like NPS can be passed down through only one parent. The syndrome can affect the tissues of the ectodermal layer, meaning the skin tissues and it can also affect the mesodermal layer, meaning the inner layer of an embryo (JCR: Journal of Clinical Rheumatology). NPS also may affect the renal, skeletal, and ocular parts the body. The syndrome affects the LMX1B gene, this is located on the 9th chromosome. Mutations on the 9th chromosome can result in iliac horns. These iliac horns are horn-like mutations to the pelvis. This occurs in 70% of the people affected by Nail-Patella syndrome. Another
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