Research Paper On Perampanel

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Introduction Perampanel (Fycompa®) is a new antiepileptic drug used as a secondary therapy in adolescents and adults who suffer from partial-onset seizures. Perampanel was identified via a focused discovery program at Eisai Research Laboratories in London and Ibaraki Prefecture, Japan (Satlin, Kramer & Laurenza, 2013). It is a selective, non-competitive antagonist drug and is the first in this new class of antiepileptic drug known as a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist on post-synaptic neurons; thereby selectively preventing the transmission of seizures by blocking the effects of glutamate(Perucca, French and Bialer, 2007). Glutamate affects how electrical activity is spread in the brain and it is believed perampanel helps to reduce seizures by blocking this electrical spread to the brain (Plosker, 2012). This is a…show more content…
AMPA receptors are localized at a postsynaptic level and under normal condition transduce responses to glutamate, released before the junction across which a nerve impulse passes from an axon terminal to a neuron, muscle cell, orgland cell. In the brain, AMPA receptors are the most represented ionotropic glutamate receptors and mediate excitatory neurotransmission. Hypersensitivity and overexpression of AMPA receptors in human epileptic hippocampal and neocortical tissue has been reported and an excessive glutamate release has been observed during seizure activity. (Zaccara et al., 2013) studies Suggest that reducing the overstimulation of AMPA receptors via AMPA receptor antagonism can have an anticonvulsant effect and inhibit seizure generation and spread. In addition to their anticonvulsant effects, AMPA receptor antagonists could play an important neuroprotective role by preventing neuronal death and could elicit an anti-epileptogenic effect (Franco et al.,
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