Retinitis Pigmentosa

1950 Words8 Pages
The study proposed herein aims to accomplish the following: To determine the optimal exposure, gamma, contrast, and brightness corrections necessary to increase the perceived contrast of images by individuals affected by Retinitis Pigmentosa (RP) and to determine the optimal image overlay of input signals corrected at both high and low thresholds such that perceived contrast is maximized. Additionally, this study will develop an I/O system of minimal necessary size responsible for image processing following image acquisition from micro cameras that will output post-processed image data onto small, high resolution LCD/LED screens contained in a wearable binocular device similar to commercially available home theater glasses. Lastly, this…show more content…
Retinitis Pigmentosa (RP) is one of such currently untreatable causes of blindness. RP, along with Age Related Macular Degeneration (AMD) are amongst the more frequent causes of blindness in the developed world (Greenwald 2009), while RP itself is the leading cause of inherited blindness (Palanker 2004). To understand the diverse causes of RP, a basic understanding of visual perception is required. Phototransduction (conversion of light to electrical signals) occurs first, which is initiated by two types of photoreceptors: rods and cones. These two types vary in their function as rods are primarily responsible for night vision and lack sensitivity to color while cones function in color vision. Light contacts these photoreceptors, and isomerizes a retinaldehydechromophore (retinal) which is bound to varying types of opsin proteins corresponding in their reactivity to different wavelengths of light. Upon absorption of a photon of light, the chromophore 11-cis-retinal is isomerized to the all-trans confirmation, which subsequently causes a series of molecular interactions which ultimately result in the electrical response of the photoreceptors (Vugler 2010). As 11-cis-retinal is required to absorb photons of light, this compound must be regenerated, a function that is performed with the aid of nearby cells of the retinal pigment epithelium
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