Review Of Surgery Versus Surgery Alone For Colorectal Cancer

1720 WordsMar 13, 20177 Pages
Research Summary Study # 1 Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Colorectal Cancer This study was meta-analysis review, over six studies using randomized controlled clinical trials, and is Level I on the hierarchy of evidence (Stillwell et al., 2010). These trials were conducted between 2002 and 2012, and the researcher conduced their search in 2014. They compared 1393 patients (50.6% of their population studied) using neoadjuvant chemotherapy 1358 patients (49.2%) using surgery alone. All patients had colorectal cancer, and mirrored each other in the percent of male vs. female and age. The researchers separated their data by the location of the tumor –ascending, descending, transverse, sigmoid and rectum.…show more content…
According to their conclusions overall among all of the studies, neoadjuvant chemotherapy seemed to reduce or delay the possibility of distant metastasis—especially to the liver— in patients with colorectal cancer (Huang, et al., 2014). Study # 2 Neoadjuvant Chemotherapy and Surgical Management of the Axilla in Breast Cancer: A Review of Current Data This is a systematic review that has looked over several randomized studies, nine in total, in regards to whether neoadjuvant chemotherapy (NAC) can impact patients who would otherwise have an axillary lymph node dissection (ALND). This is an example of a Level I evidence Stillwell et al., 2010). Sixty-one percent of women with stage I or II breast cancer will have a breast conservation surgery (BCS) and 36%, a mastectomy. However, in those with stage III, 72% will have a mastectomy instead of BCS (American Cancer Society, 2016). The researchers found studies that showed that some patients who could undergo breast-conserving therapy (BCT) after their tumor had been down-staged. The researchers mentioned data from another study that followed more than 403 patients, 22% of which had metastasis, but had a complete response to neoadjuvant treatment. Eighty-seven percent of the ones who had the complete response had a recurrence-free survival. They found overall that the patients with node-negative sentinel

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