Zagazig University Faculty of Medicine Rheumatology and Rehabilitation Department Serum Interleukin-23 Level in Patients With Rheumatoid Arthritis and its Correlation with Disease Activity and Severity Protocol of thesis Submitted for partial fulfillment Of M.Sc. Degree In Rheumatology and Rehabilitation By Enas Tawkal Eldesoky MB.B.Ch Resident of Rheumatology and Rehabilitation At Dekrens General Hospital Under supervision of Pro. Dr.
Rheumatoid Arthritis Jacob Elisha Carrington College Immunology 09/17/2015 Rheumatoid Arthritis Living on this Earth, humanity may encounter many different viruses, and infectious diseases which have the potential to jeopardize a well-being. In regards to autoimmune diseases, these types of conditions are due to your body’s immune system fighting off its own self. One of the more unfortunate autoimmune diseases attacks joints, and it is called Rheumatoid Arthritis. This disease can
Rheumatoid Arthritis or (RA) is an autoimmune disease that attacks the joints and connective tissue. The result is inflammation that produces permanent damage in the joints. Rheumatoid arthritis is a chronic syndrome that tends to be progressive and destructive as compared to Osteoarthritis or (OA), which is more of an age related disease caused by “wear and tear” of the joints. In contrast to (OA), rheumatoid arthritis is characterized by inflammation mostly of the joints, but is a general body
Since this disease has chronic, systemic, autoimmune, and inflammatory characteristics, the initial diagnosis is rarely rheumatoid arthritis. The common use of the term arthritis “can oversimplify the nature of the varied disease processes and the difficulty in differentiating one from another” (Grossman, 2014, p. 1499). The diagnosis of rheumatoid arthritis is “made clinically based primarily on physical examination findings” (Gibofsky, 2012, p. 295), which can be a cause of misdiagnosis, since
Rheumatoid Arthritis Brandon Holley PAS5430 Winter 2017 - Class 6 Clinical Presentation Disease Overview. Rheumatoid Arthritis (RA) is considered the most common autoimmune inflammatory arthritis disease diagnosed in adult patients and affects quality of life and leads to increased mortality rates. It is defined as a chronic, inflammatory, systemic autoimmune disorder characterized by symmetric, erosive synovitis that often leads to joint destruction, deformity, and disability.
cells were able to detect the presence of psoriasis related pro-inflammatory markers TNF (tumor necrosis factor) and IL-22 (an interleukin) in combination, through linked receptors (Di Domizio and Gillet 2015). TNF receptor signals first activate IL-22 receptors (IL-22R), which in turn switches a signal transducer and activator of transcription 3 (STAT3) on. The STAT3 responsive promoter finally drives the manifestation of anti-inflammatory cytokines IL-4 and IL-10 (Di Domizio and Gillet 2015). This
Description: Rheumatoid arthritis is a chronic inflammatory disease affecting the joints, most often in the hands and feet. It results in swelling, stiffness, pain, and sometimes joint, bone, and cartilage destruction. Rheumatoid arthritis usually affects joints on both sides of the body equally, meaning if a joint on one side is affected, the same joint on the opposite side is affected as well. Rheumatoid arthritis belongs to a group of diseases called autoimmune disorders that affects joints. In
becomes a chronic condition. “Rheumatoid Arthritis is the autoimmune inflammatory condition that involves an immune response to the synovial membrane, causing synovitis. Proteins are released at the site or where the joint inflammation is. This eventually causes damage to the cartilage, bone, tendons, and ligaments of the affected joint. This eventually causes the joint to lose its shape and alignment, causing deformity and great pain. It is believed that the disease is triggered by an infection
Rheumatoid arthritis (RA) is an autoimmune disease that affects the cartilage in one 's joints, it is not curable, it can not be stopped, only the pain itself can be lessened. In an average person’s body, the immune system has one job; to attack foreign substances that may enter the body. With the 1.5 million people in the United States that have been diagnosed with rheumatoid arthritis, their bodies are “tricked” or mislead into thinking that the cartilage within their joints is what is foreign
Background: Rheumatoid Arthritis (RA) is a chronic autoimmune and inflammatory disease featuring progressive joint damage leading to functional impairment and disability (1). RA is classified as a progressive systemic disease due to the extra-articular manifestations involving the lungs and eyes but beginning and principally affecting the synovial joints (1). RA patients present with a wide array of joint functional impairment with persistent disease activity (1). RA affects approximately 0.8% of