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Rheumatoid Arthritis : The Most Popular Autoimmune Disease

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Abstract
According to research, rheumatoid arthritis (RA) is the most popular autoimmune disease. RA is known to be a prolonged, systemic disease that causes inflammation. This inflammation can potentially disturb the synovial tissue that is in the body which eventually leads to damage in the joints, disabling functional abilities, and sometimes even leading to death. Many different factors can be held accountable for the diagnosis (Korczowska, 2014). Throughout this display of research many different ranges of aspects will be discussed. This illness is seen in tremendous amounts amongst physical therapy. The etiology, which happens to be the cause of this case of arthritis, and the signs and symptoms, will be revealed. Certain medical and…show more content…
Shankman and Manske include in their text that a bacterial or viral infection is said to activate this disease, which prompts the autoimmune reaction. This type of reaction helps the body attack at its own tissues, which eventually leads to the failure of the joints. The intricate details of RA are that it destroys the synovium lining, which triggers expansion, causing the bone cartilage and extracellular matrix to damage. The autoimmune response, associated with RA, also leads to the initiation of T cells. T cells are known to produce cytokines. A little information of cytokines is that it enlarges the foundation of macrophages and fibroblast-like cells which leads to the interruption of bone and cartilage (Shankman & Manske, 2011).
According to O’Sullivan and colleagues, RA is an autoimmune disease, where the etiology is not known and can be complicated. This disease is currently understood to have a genetic back ground determined by the risk of disease enlargement and grouping of families (O’Sullivan, Schmitz, & Faulk, 2014). O’Sullivan et al moves on to express that an antigen, (which is a foreign substance acting towards the host), starts to push the immune system into action, causing the immune system to react. Then the immune system reacts directly to the antigen by cellular immunity or by the creation of antibodies, immunoglobulins that are a form of serum protein, proceeds to travel in the serum by humoral immunity (O’Sullivan et al.,
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