Rheumatoid Arthritis : The Most Popular Autoimmune Disease

3121 Words Nov 13th, 2014 13 Pages
According to research, rheumatoid arthritis (RA) is the most popular autoimmune disease. RA is known to be a prolonged, systemic disease that causes inflammation. This inflammation can potentially disturb the synovial tissue that is in the body which eventually leads to damage in the joints, disabling functional abilities, and sometimes even leading to death. Many different factors can be held accountable for the diagnosis (Korczowska, 2014). Throughout this display of research many different ranges of aspects will be discussed. This illness is seen in tremendous amounts amongst physical therapy. The etiology, which happens to be the cause of this case of arthritis, and the signs and symptoms, will be revealed. Certain medical and
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According to O’Sullivan and colleagues, RA is an autoimmune disease, where the etiology is not known and can be complicated. This disease is currently understood to have a genetic back ground determined by the risk of disease enlargement and grouping of families (O’Sullivan, Schmitz, & Faulk, 2014). O’Sullivan et al moves on to express that an antigen, (which is a foreign substance acting towards the host), starts to push the immune system into action, causing the immune system to react. Then the immune system reacts directly to the antigen by cellular immunity or by the creation of antibodies, immunoglobulins that are a form of serum protein, proceeds to travel in the serum by humoral immunity (O’Sullivan et al., 2014). The authors then state, these known reactions then produce two broad types of lymphocytes. There happens to be, cellular immunity which is held accountable under T cells, and the type that accumulates circulating antibodies which are precise to that certain antigen. There are antibodies that are exclusive to the immunoglobulin G, known as IgC, called rheumatoid factors (RFs) are located in around 70% of patients who have RA. Leading to state that, a rheumatoid epitope has been found within the DNA typing of HLA-DR4 with an exact arrangement of amino acids, which is popular among
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