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Rheumatoid Case Study

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Pathophysiology:
Rheumatoid is a Chronic inflammatory disease , which is an inflammation in synovial tissues lining of joints causing proliferations and erodes cartilage & bones surface .the surrounding tendons and muscles that stabilize the joints will become weak and lose its function , leading to joints damage
It occurs when the immune system start to attack its own body against the membrane lining joints, sometimes Hormonal and environmental factors can act as triggers .
It occurs in women more than males and age of onset reaches its peak in the fourth decades.
Rheumatoid affects mainly the wrist and fingers and sometimes the other parts of the body like neck , knee, hips , ankle .. etc
If it occurs for example in one knee or hand …show more content…

Rheumatoid characterized by joint involvement and extra-articular manifestations some are commen and some are not
 Diagnostic tests : There is no specific single diagnostic test , there is combination of the display of the joint involved ; depend of clinical presentation : clinical, laboratory, and imaging features. o Laboratory tests ( Routine examination) :
1- ESR ( Erythrocyte Sedimentation Rate “sed rate” ) : usually high This test is normal blood test which a sample of blood is drawn from the vein using a sterilized needle, then The blood is amassed in a sample test tube which is then sent to be tested in lab . It take few minutes . and if the test result is higher than normal may be associated with an autoimmune disorder, such as Rheumatoid arthritis . (link )
2- CRP ( C-reactive protein test) ) : usually high
Test of the level of C-reactive protein in the bloodstream that indicates general levels of inflammation in the body. , a normal CRP level is less than 10 milligrams per …show more content…

2- Magnetic resonance imaging (MRI) : mainly cervical spine
3- Ultrasonography of joints
. (William .C. (2017 ) , (( Howard. R. (2015)) [R2]
 Treatment : . DMARDS (Disease-modifying Antirheumatic Drugs ) is the Optimal treatment for people who suffered from RA . it can be classified as : Drugs that can repression the disease pathway like :
4- Gold : it could be a treat but it has many severe negative effects for 5% of patient
5- Penicillamine: agent that’s similar to the ation of gold used to treat many cases , usually the rate of its onset is slow .
6- Sulfasalazine: agent that’s similar to the ation of gold , to treat failed RA in responding to (NSAIDs) .
And also drugs that can affect the immune process like :
7- Chloroquine and hydroxychloroquine: it is an antimalarial agent to treatment RA, it’s usually better than gold or penicillamine.
8- Methotrexate: in the UK it classified to be the most common agent for the early treatment of (RA ) .
 Azathioprine , Ciclosporin, Leflunomide and others are also examples of drugs that can help in Rheumatoid Arthritis treatment. (Laurence .K.(2014)(link)

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