Rna Interference ( Rnai ) Drugs

1382 Words Dec 7th, 2014 6 Pages
RNA interference (RNAi) drugs are drugs that alter the protein production of the desired cells/tissues by altering their RNA. The field of RNA interference is fairly recent with study of the mechanisms that enable it starting in the 1990s and continuing today. Through the years, it has been known as co-suppression, post transcriptional gene silencing, quelling, and others due to the ability to deactivate or suppress certain genes, mostly in Eukaryotes. RNAi has proved to be a very powerful instrument in medicine, biotechnology, genomics and others. The medicines currently produced can actually stop the production of certain proteins to treat specific illnesses, essentially making a genetic “off switch” for certain genes. A common focus of RNAi is targeting cancers, liver disease, and Hepatitis C., by utilizing small single and double sided RNA segments that alter the host RNA, allowing for little to no DNA change while stopping the function and reproduction of the target. One of the only downsides to this kind of treatment is that it is nonreversible and must be taken slowly to study its effects in total. This growing field is a perfect example of how simple genetic concepts are able to help shape human health forever. In Elbashir, Lendeckel, and Tuschl’s article, they explore how 21- and 22-nucleotides RNAs mediate RNA interference by using an in vitro Drosophila system; this article is still referenced today as an authoritative source for RNAi research They show that the…
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