Role Of The Wnt / Β On The Treatment Of Acute Respiratory Distress Syndrome ( Ards )

"Embryonic stem cells are special because they are the only cells that can make all parts of the body,” said Douglas Melton, in an interactive videoconference available at athome.harvard.edu. The conference was hosted in New York and broadcasted to Cambridge, Washington D.C., and Naples, Florida on March 2, 2004. "Embryonic stem cells can do everything. So if you want to work on replenishing tissues, that’s where you go."

The stroma is a connective tissue of an organ, gland, or other structure. Mesenchymal stem cells, also known as stromal cells, are stem cells isolated from the stroma. They are discovered in bone marrow, and are capable of making bone, cartilage and fat cells. 4. Induced Pluripotent Stem Cells

Michael Longaker’s interests lie at the intersection of wound/bone regeneration and stem cell biology. In the Peripheral Blood-Derived Mesenchymal Stem Cells: Candidate Cells Responsible for Healing Critical-Sized Calvarial Bone Defects, the efficacy of peripheral blood (PB) for use in regenerative medicine is significant, with its retrieval viewed as relatively easy. Experiments such as bone regeneration were carried out with the use of PB stem cells. The paper finds that through a specific coculturing process mesenchymal cells can be derived from PB (CD34+) which happen to be choice candidates for quicker bone healing and re-calcification in bone defects (Li). The key discoveries here are the identification of easily retrievable source of stem cells, which help give rise, under a specific culturing protocol, to a specific group of non-hematopoietic cells. This is directly in line with Dr. Longaker’s research as he investigates the possible uses of regenerative medicine in skeletal regeneration. Here we are provided an example of how these CD45- cells can be utilized for treatment of bone defects as it facilitations bone formation and osteogenesis. What should be asked here is how viable is this form of treatment. There is a lot of discussion surrounding the necessary conditions to produce these BD-MSCs and how it is very condition dependent. It would have been preferable to know the amount of time and the amount of cells required to see efficient

Tissue specific stem cells can create different cells for different organs and are obtained from different organs and tissues. Embryonic stem cells can increase every cell type in an adult body and are obtained from the blastocyst, a ball of cells formed a couple of days after an egg cell is fertilized. Mesenchymal stem cells are typically obtained from bone marrow and can produce bone and fat cells. Induced pluripotent stem cells are made in a science lab by changing tissue specific cells into embryonic cells and they help scientists research normal development.

To give a short overview of the steps that will be taken to complete the study. Obtaining stem cells, whether adult, embryonic or induced, shall be done using healthy mouse models and after ethical approval has been gained. The process to derive them will be detailed below, however they are also purchasable commercially with the benefit of being well studied and accompanied by a detailed analysis of properties, however with a

There are a number of advantages associated with the stem cell research. As these stern cells obtained from embryos possess the capability to renew them and can set apart into a broad cell type range, the research on these stem cells can have potential comprehensive and influential applications. One of the great examples of this is the fact that embryonic stem cell research can have significant benefits for those who suffer from Type I diabetes. Moreover, embryonic stem cell research put forwards remarkable

First of all an understanding of what a stem cell is, where it comes from, and the significance of it's medical potential is essential. Stem cells are the "master cells" that form the human body or whatever other animal it is from. Stem cells can be extracted from adult tissues, bone marrow, umbilical cord blood ( ), and embryos in the blastocyst stage. Although scientists have found ways to manipulate the stem cells from adult sources into other types of cells, they claim that they are less capable of deriving the desired tissue and are not "biologically equivalent" ( ) to stem cells extracted from embryos.

Mesenchymal stem cells (MSCs) are abundant in various tissues such as umbilical cord, adipose tissue, bone marrow and the liver. Previous research has demonstrated that the intradermal injection of umbilical cord-derived MSCs do not trigger an allergic reaction and hence the limited capacity of UCMSCs. In another study by Mao et al., the intramuscular injection of hUCMSCs did not cause inflammation, effusion or ulceration at the points of injection (7). Moreover, the injection in rats did not alter the heart, kidney and liver function. The results from these studies portray intramuscular injection of hUCMSCs as a possible administration

Researchers successfully attained embryonic stem cells from the embryos of mice in 1981, which led to the discovery of this process in human beings in 1998 (National Institutes of Health, 2001). Embryonic stem cells are derived from an in vitro embryo between five days and seven weeks. Regenerative medicine can benefit greatly from the characteristics of embryonic stem cells. This process enables damaged organs and tissues to heal themselves with the help of implanted stem cells matching the organ (Hunziker, 2010, p. 1). There are two traits

The reason stem cells are such a big breakthrough in medical technology is that they are cells that have the remarkable ability to grow into just about any cell in the body (Introduction n. pag). In fact, stem cells that remain in the human body after birth “serve as a sort of internal repair system,” in many tissues and organs (Basics n. pag). This is an extremely efficient way of healing since stem cells can become

According to the American Lung Association, “Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease occurring in critically ill patients.” ARDS is an extreme manifestation of a lung injury that can be associated with an acute medical problem. This occurs as a result of direct or indirect trauma to the lungs. With nearly 200,000 cases in the United States each year, ARDS is not extremely common (“Acute Respiratory Distress Syndrome”). Most people who acquire this disease are critically ill patients within the hospital. The most common predisposing medical problems of ARDS consist of: shock, trauma, pulmonary infections, sepsis, aspiration, and cardiopulmonary bypass (Ignatavicious, 2013). ARDS is a severe syndrome and even with prompt and aggressive medical treatment, almost fifty percent of those diagnosed do not survive. Those who survive have a longer hospital stay along with recurring hospital admissions throughout their lifetime (“Acute Respiratory Distress Syndrome”). Acute respiratory distress syndrome is a rapidly progressive disease which requires thorough assessment, rapid diagnosis, and emergency treatment measures in order to successfully respond to the disease process.

A few individuals with coronary illness and diabetes have gotten trial medications taking into account foundational cells disconnected from grown-up tissue, frequently from bone marrow, with shifting degrees of achievement. These mesenchymal stem cells, or MSCs, can develop into a few tissues including muscle, bone, ligament and fat yet there is no ensure that they will develop into heart muscle. This will left us with the answer to many people around the world why and how stem cells are stored.

As people in the world live longer as a result of advances in medicine and technology, more and more people are suffering from osteoarthritis, especially in the knee. Osteoarthritis in the degeneration of cartilage, which causes chronic pain and disability. Today, around 10-15% of people over the age of 60 suffer from osteoarthritis, and by 2050, it is estimated that greater than 20 percent of the total world population will experience OA (Kong et al). Today’s there are a number of treatments, many of which have serious complications or do not fix the problem. Typically for severe cases of osteoarthritis, total knee replacement surgery is the accepted treatment, however as many as 20 percent of patients still experience pain or other complications post-surgery (Freitag et al). The use of regenerative methods such as the use of mesenchymal stem cells could provide an better alternative to this procedure. Mesenchymal stem cells are found in bone marrow as well as other sources such as umbilical cord blood, adipose tissue, and muscle, and are multipotent, meaning they can differentiate into multiple tissues including cartilage, bone, and fat. Mesenchymal stem cell therapy is the future in treating osteoarthritis in the knee because it produces real cartilage, effectively reduces pain and is safe.

In the article, Acute lung injury and acute respiratory distress syndrome: Two challenging respiratory disorders, I learned about how difficult it is to diagnose a deadly respiratory disorder. Acute lung injury and acute respiratory distress (ARDS) is a secondary illness resulting from a primary disease that has been largely ignored by the veterinary community, but initial early recognition of the disease is paramount to providing a full recovery. This compounding disorder primarily affects the lungs and its associated passages and membranes in the respiratory system which becomes deadlier as it progresses. The three phases of this disease are the exudative phase, the proliferative phase, and the fibrotic phase. In order to suspect this

Human embryonic stem cells (ESCs) are pluripotent cells isolated from blastocysts, and are highly useful in studying human development (Itzkovitz-Eldor et al., 2000 p. 88). Although the National Institute of Health states that “it is not known if iPSCs and embryonic stem cells differ in clinically significant ways”, iPSCs are already being used to achieve the same results as ESCs in some applications without the use of embryos, removing the ethical concern associated with ESCs (National Institutes of Health, 2009). ESCs are capable of differentiating into all cell types, and can be used as a source of differentiated cells. In the report by Itskovitz-Eldor et al., they discuss the induced differentiation of ESCs in suspension into embryoid bodies, including the three embryonic germ layers. The authors state that “the ability to induce formation of human embryoid bodies that contain cells of neuronal, hematopoietic and cardiac origins will be useful in studying early human embryonic development” (Itzkovitz-Eldor et al., 2000 p. 88).