Essay on Role of Inflammation in Atherosclerosis

Introduction According to Heart foundation (2015) , coronary heart disease is a major cause of death in Australia, which kills about one Australian every 12 minutes. It is known that the development of atherosclerosis is the vital cause of coronary heart disease. It induces the accumulation of connective tissue rudiments, lipids, cells and other elements in the coronary artery wall (Hansson, 2005). This results in the asymmetric thickenings of the innermost layer, intima, which prevents adequate

Atherosclerosis, inflammation and cardiovascular disease In most countries, Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality. Despite advances in the treatment of acute and/or chronic coronary syndrome, additional therapies are still needed to reduce the high rates of recurrent CV events. Since 19th centaury it was suspected that the pathogenesis of atherosclerosis involves process of inflammation, which has become recognized as a contributory factor

Oxidative Stress and inflammation in Atherosclerosis: A Brief Review Abstract: Atherosclerosis is a disease in which plaque builds up inside the arteries. Arteries are blood vessels that carry oxygen-rich blood to the heart and other parts of the body. Reactive oxygen species are common by-products of many oxidative biochemical and physiological processes. They can be released by NAD(P)H oxidase, nitric oxide synthase and xanthine oxidase and activates various signaling pathways that underlie vascular

Introduction Chlamydophila pneumoniae was first proposed to be associated with atherosclerosis in 1988 by Saikku et al [1]. Similar cardiovascular disease studies have also proposed Saikku’s theory after detecting the presence of C. pneumoniae in atherosclerotic lesions of coronary and carotid arteries, which were not identifiable in healthy arteries [1]. Chlamydophila pneumoniae, previously recognized as Chlamydia pneumoniae, is a rod-shaped, gram negative bacteria that is known to cause infections

Atherosclerosis: The Silent Killer Atherosclerosis is one of a group of health problems that define coronary artery disease, oftentimes referred to as heart disease. Atherosclerosis is the leading cause of heart disease in the United States. The following is the definition provided by the American Heart Association: Atherosclerosis (ath"er-o-skleh-RO'sis) comes from the Greek words athero (meaning gruel or paste) and sclerosis (hardness). It's the name of the process in which deposits of fatty

predominant underlying cause of premature death and disability in the modern world, attributing to 4.35 deaths per year in Europe alone. 1 This general category collectively comprises of all diseases of the heart and/or blood vessels including atherosclerosis, which is a chronic inflammatory disease that manifests in the wall of arteries 2 causing their narrowing and hardening due to the aggregation of fatty plaque deposits. More specifically it affects the intimal layer of elastic arteries i.e

Current mechanism and concepts in pathogenesis of Atherosclerosis Introduction Atherosclerosis is classified as a chronic, progressive, and multifactorial disease of moderate and large sized arteries categorised by intimal lesions called atheroma plaques that pushes into the vessel lumens. Atherosclerosis leading to coronary artery is the main cause of coronary artery disease (CAD). It is vital to appreciate the central mechanisms of atherogenesis in order to understand the adverse clinical results

Atherosclerosis Atherosclerosis, which is a chronic inflammatory disease amongst the arteries of the human body, remains the principal cause of cardiovascular related disease (Gets, 2011). Atherosclerosis results from a complicated relationship between different factors such as lipid metabolism, blood coagulation elements, cytokines, hemodynamic stress, and behavioral risk factors. (Singla et al., 2011) The pathogenesis of atherosclerosis involves oxidative stress, endothelial dysfunction and chronic

Atherosclerosis: The Silent Killer      Atherosclerosis is one of a group of health problems that define coronary artery disease, oftentimes referred to as heart disease. Atherosclerosis is the leading cause of heart disease in the United States. The following is the definition provided by the American Heart Association: Atherosclerosis (ath"er-o-skleh-RO'sis) comes from the Greek words athero (meaning gruel or paste) and sclerosis (hardness). It's the name of the process

(stroke) and diseases of the aorta and arteries including hypertension and peripheral vascular disease (Mendis, Puska, & Norrving, 2011). They are all due to a disease known as atherosclerosis which affects arteries (George, & Johnson, 2010). There are also other cardiovascular disease that are not related to atherosclerosis, for instance, congenital heart disease caused by abnormal structures of the heart existing at birth, rheumatic heart disease due to Type II hypersensitivity reaction following