Rosa Laevigata Is A Known Medicinal Plant, And It Has Been Widely Used For A Long Time

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Rosa laevigata Michx is a well-known medicinal plant, and it has been widely used in China for a long time. Previous studies revealed that the total flavonols fraction from the Rosa laevigata Michx has potent antioxidant, hypolipidemic, hepatoprotective and antithrombotic activities through attenuating inflammation, suppression of apoptosis and altering mitogen-activated protein kinase signaling pathways (114). Another study showed that Rosa laevigata Michx significantly ameliorates renal dysfunction in diabetic rats (115). The protection involves increasing the activity of SOD and total anti-oxidant capacity, decreasing the levels of MDA and ROS, and inhibiting the expression of NF-κB p65 and MCP-1 at both the protein and mRNA levels with an increase in the expression of the IκBα protein (115). Total flavonoids from Rosa laevigata Michx fruit attenuated cell injury and decreased SCr and BUN levels in rats with ischemia/reperfusion injury (116). They also decreased the levels of MDA, SOD, GSH and GPx and ROS, up-regulated the levels of Nrf2, Sirt1 and HO-1, down-regulated the levels of KEAP1 and NF-κBp65, and decreased the mRNA levels of IL-6, IL-1β, and TNF-α. Furthermore, inhibiting Sirt1 attenuated the protecting effect of the total flavonoids on renal ischemia/reperfusion injury, suggesting that the effect of the extract depended on Sirt1. Therefore, the total flavonoids has nephroprotective effect against ischemia/reperfusion injury by affecting Sirt1/Nrf2/NF-κB

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