Rotavirus Essay

Viruses, Plagues, and History, written by Michael Oldstone, is an insightful and highly educational book that details the history of, that’s right, viruses and plagues. Through typically dry, yet engaging prose, Oldstone recounts what seems like all of it while simultaneously bringing to light the contributions of those brave scientists who asked themselves, “why.” He focuses his attention on some of the most notable viruses such as smallpox, yellow fever, measles, polio, and later he focuses on more contemporary battles against disease.

The virus fuses with the cell’s plasma membrane. The capsid proteins are removed, releasing the viral proteins and RNA. Reverse transcriptase catalyzes the synthesis of a DNA strand complementary to the viral RNA. Reverse transcriptase catalyzes the synthesis of a second DNA strand complementary to the first. The double-stranded DNA is incorporated as a provirus into the cell’s DNA. Proviral genes are transcribed into RNA molecules, which serve as genomes for the next viral generation and as mRNAs for translation into viral proteins. The viral proteins include capsid proteins and reverse transcriptase (made in the cytosol) and envelope glycoproteins (made in the ER). Vesicles transport the glycoproteins from the ER to the cell’s plasma membrane. Capsids are assembled around viral genomes and reverse transcriptase molecules. New viruses bud off from the host cell.

This was one of the most significant pieces of history that solved deadly viral cases and

virus with the normal flu virus. He found the key difference which was a mutation in the genetic

The SH (small hydrophobic) protein, matrix protein (M), and the M2 protein are envelope-associated proteins that are not involved in viral attachment or syncytium formation (3). Other proteins such as the nucleoprotein (N), phosphoprotein (P), and the large nucleoprotein (L) are in the nucleocapsid. NS-1 and NS-2 are non-structure protein that is only found in the infected cells but not present in virions (3).

First, since we know the viral RNA sequence and its targeting protein, we can investigate it in bioinformatics database, and can acquire some clues or hints about the target proteins. From the bioinformatics database, we might be able to find its structure, similarity with other proteins, functions, and binding domains. In other words, we can get some partial or complete amino sequences of the targeting proteins or information about likeness.

There is still a great deal of information to learn from the study of viruses and the continued exploration of the viral genome is crucial in understanding how viruses communicate, transmit from host to host and evade immune responses. The ever-change nature of the viral genome has shown us that the most dangerous viral infections of today may be undermined by newer and more effective viruses, resulting in catastrophic outcomes. Through the study of viruses, it is the hope of the scientific community to be ahead of the viral curve, preventing infections before they even

Because of the rapid circulation of this “virus”, it was inevitable that Valley High School’s own students would become exposed to such an ailment.

The issue for healthcare professionals is their exposure to patients with the virus, and treatment process of deal

Proteins are polymeric chains that are built from monomers called amino acids. All structural and functional properties of proteins derive from the chemical properties of the polypeptide chain. There are four levels of protein structural organization: primary, secondary, tertiary, and quaternary. Primary structure is defined as the linear sequence of amino acids in a polypeptide chain. The secondary structure refers to certain regular geometric figures of the chain. Tertiary structure results from long-range contacts within the chain. The quaternary structure is the organization of protein subunits, or two or more independent polypeptide chains.

Through their research, the scientists were able to come to the conclusions that when the Vesicular Stomatitis Virus was injected it attacked brain cancer cells. The team used scientific supercomputers and and Grid Technology to uncover, through genetic code, the VSV’s glycoproteins bind to host cells, causing the infected cell to burst. By advancing our techniques and accepting the growth of technology within our societies, we are able to innovate new ideas and inventions that can better the future. The advancement of technology has created a safe environment for scientists to challenge new ideas, and in this specific case, has saved thousands of

Chikungunya is a small spherical enveloped virion that measures up 60 to 70nm in diameter. It contains a single strand positive-sense RNA genome (Solignat, Maxime 2009). The virus has a lipid bilayer containing heterodimeric protein spikes composed of two major surface envelope glycoproteins E1 and E2 (Understanding the alpha virus). The genome extends approximately 12 kb long, and is organized in a 5’ cap -untranslated region (UTR), non-structural proteins (nsP1-4), structural proteins (C-E3-E2-6 K-E1), and a 3’ polyA tail end( Microbes and Infection). The structural proteins of the virus are created by the translation of a messenger RNA (mRNA). The 5’ end cap of the genome has a 7- methyl guanosine cap, whereas the 3’ end is polyadenylated

The protective capsid helps the virus escape detection and destruction during the invasion of the host. When the virus reaches the target cell, biochemical reactions between the capsid and cell wall allow the virus to latch on and inject its genome into the cell’s interior. Once inside, the viral genetic material insinuates itself into the host’s DNA or RNA. In an efficient feat of natural bioengineering, the host cell’s genetic machinery now does the rest of the work for the virus. The cell, which had already been making copies of its own genome, now also replicates that of the virus. Coded within the viral material is the blueprint for making more copies of the viral genome. Further instructions command the production of capsids and directions for assembly of new viruses. After the host cell becomes engorged with viruses, it explodes, sending the new

The HIV-1 virion is approximately 120 nm in diameter, roughly spherical, and is composed of two copies of a single stranded positive sense RNA enclosed by a capsid (24). The HIV-1 genome is less than 10 kb and encodes for more than nine different gene products. It encodes for 3 major structural protein genes: gag (group-specific antigen), pol (DNA polymerase), and env (Envelope), which code for major structural proteins and essential enzymes. Gag generates the mature Gag protein matrix (MA or p17), capsid (CA or p24), nucleocapsid (NC or p7), and p6, which encompass proteins for the basic infrastructure of the virus such as the inner core of the viral particle (25). Pol encodes for reverse transcriptase (RT), which enables the virus to reproduce, integrase (IN), which is necessary to integrate the viral double stranded DNA into the host genome, RNAse H, and HIV protease, which are all encapsulated in the core of the inner particle formed by the viral capsid protein p24 (25). Env encodes for glycoproteins of the outer membrane such as outer gp120 (which enables the virus to attach and fuse to cells of the host), and transmembrane gp41 that anchors the glycoprotein complex to the surface of the virion (25). Between the core and the envelope is the HIV matrix proteins which are composed of the viral protein p17 (23). HIV-1 also encodes for proteins with important regulatory elements (tat (Trans-Activator of Transcription) and rev

The similarity between the poliovirus and already solved plant virus’s led to a better understanding of how the poliovirus can regenerate within a host. Although the virus was similar to other plant viruses. The poliovirus was covered with more elaborate loops that are the site of monoclonal antibody escape mutations (Hogle, Chow and 229: 1358-1365Filman, Science). Individual proteins of the virus particle are produced by proteolytic cleavages from a larger precursor, yet the amino and carboxy-termini produced by proteolysis are very distinct. By noting this, Hogle and his team were able to conclude that proteolysis was not just making a lot of proteins from one gene, it is also controlling the timing of assembly (Hogle, Chow and Filman, Science 229: 1358-1365).