SLE Essay

The awareness of SLE has spread exponentially during the last decade, this is observed especially for women who are getting diagnosed earlier and then move on to treatment. However,

     There are three different types of Lupus. They are: Discoid, Systematic, and Drug-Induced. Discoid Lupus only effects a persons skin. The only symptom of Discoid Lupus is a rash. Systematic Lupus is the most common form of Lupus. It effects

Lupus is a chronic inflammatory disease of unknown cause that can affect virtually any part of the body. The medical term for Lupus is Systemic Lupus Erythematosus or better known as SLE. With Lupus there is a malfunction in some of the cells of the immune system. "In Lupus, the body overreacts to an unknown stimulus and makes to many antibodies, or proteins directed against body tissue. Thus, Lupus is called an autoimmune disease. ”#

Lupus is an autoimmune disease that attacks women between the ages of 15 and 40. It occurs less often in men than in women. The people affected by lupus vary depending on the country or region. In the US alone, the prevalence rate is highest among Asians of Hawaii, blacks of Caribbean origin, and Native Americans of the Sioux, Arapahoe, and Crow tribes. Lupus is a disease that affects the immune system. We can think of the immune system as an army within the body with hundreds of defenders (known as antibodies). They defend the body from attack by germs and viruses. In lupus, however, the immune system becomes overactive and creates antibodies that attack healthy tissues in the body, such as: the skin, kidneys, lungs, heart and brain.

Systemic lupus erythematosus, or simply lupus is a chronic autoimmune disease or immune system malfunction. A person's immune system normally protects the person from viruses, bacteria and other foreign materials. When a person has an autoimmune diseases like lupus, the immune system turns against itself and attacks itself.

Szuda, Stephanie “Health: Life with Lupus.” The Times. 11 Jan 2008. 19 Nov 2010. <Mywebtimes.com>

SLE diagnosis is made on 4 findings present at the same time or in a series. 11 common findings include: malar rash, disc shaped rash, photosensitivity, oral ulcerations, nonerosive arthritis, serositits, presence of ANA, and renal, neurologic, hematologic, and immunologic disorders. The X-ray finding is also significant, because the inflammation without erosion of the joints is a key finding in SLE. Other labs (like those listed above) are used in combination to also aid in diagnosis of SLE.

Let alone the cause of this horrible disease. One of the most commonly suspected reasons for systemic lupus erythemotosus (SLE) is a very low iron count. Low iron has a veriaty of effects on the body including the feeling of being cold, low blood count (anemia), and impaired immune defiecency, ect.. Thus the low iron syptom seems to add up with lupus making doctor think that low iron can have a leading from in the disease.

Both medical journals provide similar information about SLE dealing with genetic influence, hormones, cytokines and similar treatment. Only difference is Mechanisms of Disease Systemic Lupus Erythematosus gives information about environmental influence and A Review of Systemic Lupus Erythematosus and Current Treatment Options journal has no evidence to support any environmental influence. It gives details about the new medication, Belimumab, which was approved by Food and Drug Administration (FDA). The results are small but significant beneficial with the blockade of B-lymphocyte stimulator with an anti-BLyS antibody (Tsokos, 2011). Another new treatment option is small molecule inhibitors of kinases such as Syk and CaMK4 that are showed in the immune cells of patients with SLE (Tsokos,

Do you know that there is currently three types of lupus? Discoid lupus, systemic lupus erythematosus, and lupus like a disorder called destroyer made lupus. Discoid lupus remains limited to our skin and be present in the form of a rash that appears on your face, neck or scalp. The appearance of the rash may possibly be more outward on areas of the skin exposed to electromagnetic lighting. While close by stand many forms of lupus epidemics the most communal is elevated, incrusted and rosy nevertheless not irritated. SLE remains commonly extra plain than discoid lupus. Do you know Discoid lupus is a form of lupus that is be able to cause inflammation in your organs?On behalf of nearly half of our society, this can be to

The following search mechanism was used: (“lupus, African Americans” [MeSH Terms] OR (“lupus” [All Fields] AND “African Americans” [All Fields]) OR (“lupus, blacks” [MeSH Terms] OR (“lupus” [All Fields] AND “blacks” [All Fields]) OR (“lupus, minorities” [MeSH Terms] OR (“lupus” [All Fields] AND “minorities” [All Fields]) OR (“SLE, African Americans” [MeSH Terms] OR (“SLE” [All Fields] AND “African Americans” [All Fields]) OR (“SLE, blacks” [MeSH Terms] OR (“SLE” [All Fields] AND “blacks” [All Fields]) OR (“SLE, minorities” [MeSH Terms] OR (“SLE” [All Fields] AND “minorities” [All Fields]) OR (“lupus, race” [MeSH Terms] OR (“lupus” [All Fields] AND “race” [All Fields]) OR (“SLE, race” [MeSH Terms] OR (“SLE” [All Fields] AND “race” [All Fields]). A total of 344 results were obtained and the title and abstract were reviewed by two of the authors (EMW and LB). The inclusion criteria were original research papers related to the prevalence and clinical course of SLE in African Americans. We excluded literature reviews, case reports, and surgical techniques articles. We also excluded papers published before 2000. In addition, a manual search of all referenced articles not found in the main search was performed. A total of 71 full papers were full reviewed, but we also excluded 38 additional papers because they were case studies or not limited to African Americans, for a total of 33 studies included

Systematic lupus erythematosus (SLE) is a chronic, systemic, autoimmune disease. This condition causes the body to mistaken its own tissues and organs as foreign bodies and begins attacking them causing continuing inflammation and pain. (Huether & McCance, 2012) The cause of SLE still remains unknown, but it is possible that is inherited as a complex trait or caused by environmental stimuli. (S) Anyone is at risk for Lupus, but is more common among women than men and is more prevalent of African Americans and Asians. (National Library of Medicine 2010, para 2) This condition can be difficult to diagnose, as a patient must present a number of the recognizable symptoms. Depending on the location that Lupus presents itself in the body, the symptoms

Makover, M. & Zieve, D. (2011, February 14). Systemic Lupus Erythematosus. National Center for Biotechnology Information. Retrieved July

Systemic Lupus Erythematosus is a chronic autoimmune disease which causes inflammation of your joints, tissues, and organs. The inflammation presents itself as heat, pain, swelling and redness. SLE is a variable disease that doesn’t take any one particular course; therefore its unpredictability makes it even more devastating. No two people will experience the same disease symptoms or severity level. As S.L.E progresses there will be periods of very subtle to no symptoms at all called remission or an exacerbation of symptoms called flares.

Thus, testing for ANA or ANA-specific autoantibodies have been incorporated in a number diagnostic criteria. For example, a positive ANA finding was incorporated as a diagnostic criterion for SLE [18, 19]. In 2013, a joint committee of the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) formulated a new set of SSc classification criteria which included the ANA-specific autoantibodies, namely; anti-topoisomerase I (anti-topo I or anti-Scl-70), anti-centromere (ACA), and anti-RNA polymerase III (anti-RNAP III [20].