Bronchodilator Response of Nebulized Salbutamol versus Salbutamol and Ipratropium Bromide in Adult Patients with Acute Severe Asthma
Introduction:
Acute severe asthma previously called status asthmaticus is a life threatening medical condition characterized by bouts of repeated and worsening cough, wheezing, chest recession and inability to speak or drink that may result in acute respiratory failure and even death.1 These patients are also at risk for developing serious complications like aspiration pneumonia, pneumo-mediastinum, pneumothorax and hypoxic brain injury etc. 1Inhaled high dose short acting β2 agonists like salbutamol along with systemic steroids and supplemental oxygen are considered as first line treatment in all patients who
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Rationale:
Although there are local studies on various aspects of asthma, there is no local study in Pakistan published so far which compares the response of nebulised salbutamol alone with combination of ipratropium bromide in adult population with acute severe asthma. This study has been planned to compare these two approaches. My study will help for better management of patients who report to emergency department with this potentially life threatening
R.J. is a 15-year-old boy with a history of asthma diagnosed at age 8. His asthma episodes are triggered by exposure to cats and various plant pollens. He has been using his albuterol inhaler 10 to 12 times per day over the last 3 days and is continuing to wheeze. He normally needs his inhaler only occasionally (2 or 3 times per week). He takes no other medications and has no other known medical conditions. Physical examination reveals moderate respiratory distress with a respiratory rate of 32, oximetry 90%, peak expiratory flow rate (PEFR) 60% of predicted, and expiratory wheezing.
My coworker had a 40-year-old patient who came to the hospital for alcohol withdrawal. All the nurses on our floor knew him really well because he visits our hospital frequently. At around 7:30 pm, our telemetry showed that the patient was having a heart rate of 180s to190s. We all were still getting report. Charge nurse went to assess the patient, patient started yelling in a loud voice, throwing pillows and a blanket. It turned out that the patient went to the delirium tremens (DT) phase. He was confused, disoriented, hallucinating, agitated, irritated and had muscle tremor. When reviewing the medication administration record (MAR), charge nurse noticed that CIWA scale was not done as ordered and as a result patient did not get enough Lorazepam
Patients with severe asthma should not be given beta blockers, although those with milder symptoms may be able to tolerate these medications. Careful initiation and monitoring is
Miss Brightman’s asthma is currently not controlled, and there are several viable courses of action to consider that could reverse this. One option would be to progress Miss Brightman onto step 3; a long-acting beta2 agonist would be introduced, such as Salmeterol or Formoterol, in the form of a combination inhaler with the corticosteroid to aid compliance. However, when looking at the recommended doses for Beclometosone in the BNF, it is apparent that Miss Brightman has been extremely underdosed. The BNF states that the recommended dose of inhaled corticosteroid for an adult is 200-400μg twice daily, meaning that the
Asthma is a respiratory disease that many people deal with every single day. “According to World Health Organization, approximately 180,000 people die from asthma each year.” (Jardins and Burton 187) Most people never think of asthma as a life threatening disease, but it can be crucial. As the number of people with asthma increases, the more likely you are to come in contact with someone who has been diagnosed with this disease. Asthma is a severe breathing problem that has many complications that is dealt with daily like shortness of breath, chronic cough, tightness of the chest and shortness of breath, my main focus is childhood asthma, allergic asthma, and medication to treat asthma.
Asthma is a “chronic inflammatory disease of the airways” and causes difficulties in breathing due to the widespread narrowing of the bronchial airways1. Asthma can occur in people of all ages and affects approximately 10.2% of Australians (2011-12) 2. Generally asthma is reversible with or without treatment however over time damage may occur3. Therefore it is important for patients to manage their asthma well in order to maintain a healthy and quality lifestyle. One of the most effective treatments used to control asthma is Salbutamol. Salbutamol is a short acting B2 adrenergic agonist and it is mainly used for quick relief or to prevent the onset of asthma3. This essay will explain the physiology of the respiratory system and the effect on the system when a person has asthma. It will also discuss the use of salbutamol as a treatment for asthma.
Discuss the roles of medications, ICS for long term anti-inflammatory effect and Beta adrenergic for immediate bronchial dilation.
To better understand the impact of asthma, a brief overview of the causes (aetiology) and disease progression (pathophysiology) must be shown. As common as asthma is, not much is known about its aetiology, according to findings presented by Subbaroa, Mandhane and Sears (2009, pg. 181-187) in a review from the Canadian
I press the mask to my face gasping for air. The abuterol steaming throug my over-used nebulizer does nothing to ease my tightening chest. I've lived with
Asthma is a chronic inflammatory disorder of the airways that lead to difficulties in respiration (Kaufman & Kent 2015). It occurs when airways are over-sensitive and easily respond to a variety of intrinsic and extrinsic stimuli such as allergens, smoke, stress, emotions, medication, weather, exercise, and colds or the flu (Kaufman & Kent 2015). These triggers can offset common asthma symptoms including coughing, wheezing, chest tightness, and shortness of breath (Kaufman & Kent 2015). The type of trigger, severity, and timing of an asthma attack is unpredictable and different for everyone. In the case study, Joseph has had episodes of acute exacerbation reducing in severity in the early phases but has not experienced an attack for the last
Asthma is a chronic disease affecting the walls of your airways. These airways are made up of tubes that allow air to pass in and out of your lungs. Inflammation, as well as, increased production of mucus can cause narrowing and obstruction of these tubes, making it difficult to breathe. There are many factors that play a role in the development of asthma such as; exercise, occupation, stress, anxiety and allergens. Common symptoms patients may experience are; shortness of breath, wheezing, dyspnea, tachycardia, cough and sleep disturbances. These can be alleviated with medications and lifestyle changes. Long term asthma control medications are used to prevent asthma attacks and treat chronic symptoms. Rescue medications are used to treat a
Towards the end of September of 1982, seven people died from a Tylenol product tampering on Chicago’s West Side. Before the events, Tylenol had over one hundred million users, and was a total frontrunner in the pain-killer industry. After the tragic events, Johnson & Johnson, parent company of McNeil Consumer Products Company which makes Tylenol, had to face the world and explain why their highly-trusted product was killing its consumers. (Markel, 2014)
In the event asthma is no longer manageable by a primary clinician the need for a referral may be require. Referral to an asthma specialist for management is recommended if there are complications achieving or maintaining control of asthma. Also, if the patient required more than 2 uses of oral systemic corticosteroids in 1 year or has required hospitalization it is imperative for the individual to be referred for further management (NAEPP,
Stage III (severe obstruction): Short-acting bronchodilator as needed; long-acting bronchodilator(s); cardiopulmonary rehabilitation; inhaled glucocorticoids if repeated exacerbations
Asthma is known as a chronic respiratory disease that affects the lungs. According with the Centers for Disease Control and Prevention (CDC), estimated asthma incidence in the United States is 3.8/1000 in adults and 12.5/1000 in children. Prevalence rate of asthma in the United States increased from 7.3% in 2001 to 8.4% in 2010. Based on the statistics in the United States, it is more common that children have asthma than adults, especially women than men. Comparing with Texas, the estimated prevalence rate of asthma is an estimated of 6.8% of adults (1,296, 000 adults).