Essay on Salivary Gland Tumors

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INTRODUCTION: Salivary gland tumors are a morphologically diverse group of neoplasms, which may present considerable diagnostic and management challenges for the pathologist and surgeon. Salivary gland tumors are rare with an overall incidence in the western world of about 2.5 to 3.0 per 100,000 per year. About 80% of all lesions are benign; hence salivary malignancies are particularly rare, comprising less than 0.5% of all malignancies and about 5% of cancers in the head and neck. (1) Most of the studies on salivary gland tumors are in reference to western population and to the best of our knowledge this study is the first of its kind in Indian population. In this study, salivary gland neoplasms were retrospectively studied…show more content…
Immunohistochemical analysis for smooth muscle actin (SMA) was done and the intensity of staining and staining location were considered. RESULTS: A total of 1855 biopsy specimens were accessioned at our biopsy services during the study period (2002 – 2006). In this period, 37 cases were salivary gland neoplasms accounting to 1.99% of all biopsy specimens accessioned. Of 37 cases, 11 were benign neoplasms (29.72%) and 26 were malignant (70.27%). The common tumors overall was Pleomorphic adenoma (PA) and Muco-epidermoid carcinoma (MEC) (Table 1). Of 37 cases, 9 cases occurred in major salivary glands, with eight occurrences in the parotid region - 1 PA, 1 Adenolymphoma & 6 Acinic cell adenocarcinoma (AcADCC) and one in submandibular region- 1 Polymorphous low grade adenocarcinoma (PLGA). Of 37 cases, 28 cases occurred in minor salivary glands, with palate being the most commonly affected site by both benign (63.63%) and malignant tumors (58%). Males represented 54% of the affected patients, and certain tumors showed a strong male predilection, like MEC (6/10), PLGA (2/2), Adenoid cystic carcinoma (ACC) (5/8), Adenolymphoma (1/1); in contrast, some tumors such as PA (7/10), Acinic cell carcinoma (4/6) showed a female predilection. The mean age for malignant tumors in females (40.6 years) was lower than
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