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Sarcoplasmic Reticulum Essay

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Sarcoplasmic reticulum (SR) play’s a critical role in the function of contraction and relaxation of the muscle (John Wiley and Sons, 2003). It provides the ability to control and balance the amount of calcium being released/uptake and for storage (John & Sons, 2003). There is a correlation between defects in calcium transport by SR and the ability for the heart to function (Alpert, Arai, MacLennan, and Periasamy, 1993). By alternating the gene expression that encodes SR proteins, it will show if the abnormalities in calcium uptake and release has a association with heat failure (Alpert et al., 1993). Defects in the ability of the sarcoplasmic reticulum to uptake/release calcium could cause dysfunction in systolic and diastolic rhythm in the heart (Donald M. Bers, David A Eisner and …show more content…

Valdivia, 2003). It is considered heart failure if there is an improper function of systolic and diastolic for the heart to pump blood (Donald et al., 2003). It was difficult to obtain normal healthy hearts to compare to therefore, looked at levels of mRNA and phospholamban (regulate Ca2+ pump) that encodes SR to see the rate at which calcium is being uptake/released (Alpert et al., 1993). Patients with heart failure, showed a delay in the rate of the calcium uptake/release of about 50% decrease in the right ventricle by SR (Alpert et al., 1993).Furthermore, there was a 48% decrease of messenger mRNA in binding with ATP and uptake of calcium in the left ventricle (Alpert et al., 1993). Sarcoplasmic reticulum had a decrease rate in pumping calcium, which caused low rhythm that lead to heart failure (Alpert et al., 1993). The gene expression mRNA is important for the sarcoplasmic reticulum to

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