TTUHSC School of Pharmacy
Memo
To: John Zoidberg
From: Tuong Nguyen
Date: December 4, 2015
Re: Information on Pradaxa Dr. Zoidberg,
Thank you for your request for information regarding Pradaxa (dabigatran etexilate). As you stated, you have a patient named PF, who is planned to have hip arthroplasty in 2-4 weeks due to degenerative joint disease that is unresponsive to either physical therapy or simple pain relievers. Mr. PF is a 79 year-old male with hypertension and hyperlipidemia. His current medications include naproxen 220 mg po bid, tramadol 50 mg po tid, and enalapril 10 mg po qd. In addition, Mr. PF has the codeine allergy. Because of Mr. PF’s severe fear of giving himself shots, your concern is whether or not Mr. PF can have Pradaxa orally instead of enoxaparin 40mg subcutaneously for DVT prophylaxis and still receives the similar efficacy and safety.
The dabigatran etexilate (DE) is a prodrug that directly competes for the active site of thrombin.1 This direct inhibition inactivates both fibrin-bound and free form of thrombin. Because of its rapid onset and offset of action, there is no need for the initial parenteral anticoagulant treatment in patients with acute thrombosis.1 On the other hand, the enoxaparin indirectly inhibits factor Xa.2 It has a shorter duration of action (12h vs 24h) and a shorter half-life (4.5-7h vs 12-14h) in comparison to DE. The DE and the enoxaparin have no interaction with diet and alcohol. There is no routine monitoring required
This report is Part 1 of assignment for Marketing MBA 565-MBOL1 to Dr. Stephen Baglione
Pharmacy is a prolific field of study that is taking a prime position in the world of academia. It is quite demanding and needs completeness and vigilance. Thus, by going through pre-pharmacy, it will help me reshape my educational and career aspirations by bringing into reality what pharmacy entails through prerequisite coursework. I will also be able to come to terms with what the profession has at the end of the tunnel and asses with it marches my career goals. The profession is loaded with numerous employment and personal advancement opportunities, and I am motivated to study pre-pharmacy since it will spark of my innovativeness and optimistic that my future days would be worth the trouble.
In our experience with Pharmasim we learned that Marketing decision making must be very sensitive and responsive to everything going on in the industry which is very complex. Consumer responses to marketing tactics can be volatile and unpredictable and no idea is guaranteed to work well. Marketing is a matter of meticulous research, assumptions, planning, and volatility at times. Overall we took away two major points: 1) that it is important to consider the product lifecycle in evaluating how to promote businesses and, 2) that the “Sweet Spot” as a competitive advantage should be the greatest point of consideration when evaluating how to best gain leverage to beat the competition in the minds of
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The management team at the over-the-counter cold medicine (OCM) group of Allstar Brands is looking to utilize revenue generated by Allround to help fund new opportunities in emerging markets. Therefore, it is critical that Allround maintain its market-leading position in terms of market share, profitability, and sales in order to fund these new initiatives.
- Coagulation inhibitors and Fibrinolysis : to Localize thrombus on injury and Prevent new thrombus formation.
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