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Sclc Case Study Nursing

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SCLC is a highly aggressive tumour with a propensity for early metastases and a high case-fatality rate. Systemic treatment with doublet platinum plus Etoposide ( cisplatin 60mg/m2 D1 or carboplatin AUC5 IV day 1 ,Etoposide100mg/m2 IV Day1 and 200mg/m2 oral day 2 and 3 is recommended for all stages of this disease and has been a standard first-line therapy for SCLC since the 1980s.(Hann 2008) SCLC is aggressive tumour and if left untreated, patients with SCLC survive for a median of 2 to 4 months. SCLC is exquisitely sensitive to chemotherapy, producing an objective response rate of 60% to 80% as well high subjective response rate hours/days rather than weeks but relatively short duration response. Patients with LS SCLC, chemotherapy plus radiation is the standard of care, as the addition of radiation therapy has been shown to decrease …show more content…

In this meta-analysis four eligible trials with 663 patients (328 assigned to Cisplatin and 335 to Carboplatin) were included in the analysis. Median overall survival was 9.6 months for Cisplatin and 9.4 months for Carboplatin. There was no evidence of treatment difference between the Cisplatin and Carboplatin arms according to sex, stage, performance status, or age. Median progression free survival was 5.5 and 5.3 months for Cisplatin and Carboplatin respectively. Objective response rate was 67.1% and 66.0%, respectively. Toxicity profile was significantly different for each of the arms: hematologic toxicity was higher with carboplatin, and no hematologic toxicity was higher with Cisplatin. Furthermore, Etoposide bioavailability improved with intravenous administration patient with confounding factors such as swallowing problems or being unwell and difficulty in swallowing due extrinsic compression on the oesophagus would be better with Intravenous rout especially Etoposide tablet is big tablets

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