Screening Of Antagonistic Activity Of Marine Actinomycetes Against Clinical Pathogens

1252 Words Nov 23rd, 2016 6 Pages
SCREENING OF ANTAGONISTIC ACTIVITY OF MARINE ACTINOMYCETES AGAINST CLINICAL PATHOGENS
Ramarajan K*,Karthick .V * P.K.Senthilkumar,
Department of Microbiology,Faculty of Sciences, Annamalai University Tamil Nadu, India.
Email: ramsmicr@gmail.com

Abstract The present study was conducted to examine the ability of six promising indigenous isolates of marine actinomycetes (NA-1, 2, 3, 4 and TA-1, 2) as probiotics in nature. The actinomycetes isolated from these eco systemsare capable of producing antibiotics that strongly inhibit the growth of gram positive and gramnegative bacteria. A total of 6 isolates representing the range ofmorphological diversity observed from each sample were obtained in pure culture. However ofthe 6, two were found to produce antibiotic substances. NA1 and TA1 exhibited higheractivity and, selected for further studies. The purification and characterization of thesubstances is now in progress.

Keywords:Marine actinomycetes, Isolation, Biochemical characterization, Chemical screening,Antimicrobial activity.

INTRODUCTION
As a great promising for new natural products which have not been observed from terrestrial microorganisms, marine bacteria are being developed for the discovery of bioactive substances with new types of structure, with growing intensive interest. The achievements have been well reviewed (Bernan,et al.,1997) ,where many novel antibiotics were acquired from actinomycetes (Okami, Y & K. Hotta,1998) .Thus…
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