Seperating the Components of Panacetin Essay

668 Words Nov 9th, 2012 3 Pages
Alex Wilson
9/11/12
Experiment #2

Separating the Components of Panacetin:
Introduction:
Of the three components likely to be present in your sample of Panacetin (aspirin, acetanilide, and starch), only starch is insoluble in the organic solvent dichloromethane (or methylene chloride), CH2 Cl2. If a sample of Panacetin is dissolved as completely as possible in dichloromethane, the insoluble starch can be filtered out, leaving acetanilide and aspirin in solution. The purpose of this experiment is to extract the components of Panacetin.

Although the acetanilide and aspirin are both quite insoluble in water at room temperature, the sodium salt of aspirin is very soluble in water but insoluble in dichloromethane. Because aspirin
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We made sure the solution is strongly acidic by testing it with litmus paper getting a pH of 2. We then cooled the mixture to room temperature swirling the flask occasionally in an ice bath. We collected the aspirin by vacuum filtration and washed the aspirin on the filter with cold distilled water. We let it air dry for 30-35 minutes and then weighed the aspirin. It weighed out at 0.513g. The unknown component was calculated and weighed at 0.738g.

Results: When we were mixing the filtration and letting it vent periodically, we lost some of it. So our percent recovery is as follows:

The unknown component weighed 0.738g. And our percent composition is as follows:

Discussion:
Sucrose is insoluble in the organic solvent dichloromethane (CH2 Cl2). Aspirin, acetanilide, and phenacetin are soluble in dichloromethane but relatively soluble in water. Aspirin reacts with bases such as sodium bicarbonate to form a salt, sodium acetylsalicylate, which is insoluble in water. Acetanilide and phenacetin are not converted into salts by sodium bicarbonate.

The Reciprocal (Interconversion) of Aspirin and it’s Sodium Salt

Conclusion: The breakdown of Panacetin:
Mix panacetin with CH2 Cl2 and you will get a solid which is sucrose and you’ll get a filtrate of aspirin and an unknown substance. Then you will extract the aspirin with NaHCO3 to get an organic layer and a water layer. The bottom layer for us was the organic layer, while the top layer was the water layer.
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