Septic Shock Research Paper

The septicemic version is defined as a fast growing bacteria which if not treated properly and fast enough would eventually lead to death. What would happen inside the body would be that the bacteria would disable your body’s ability from being able to clot blood. The infected would become very itchy all over their body to the point where they made themselves bleed from everywhere. Eventually the victim would have massive blood loss leading to

The systemic inflammatory response is the next step in the continuum and is a nonspecific inflammatory state that may be seen with an infection. Sepsis is the presence of the systemic inflammatory response syndrome (SIRS) with evidence of infection. As the bacteria invade the bloodstream, they release endotoxins that damage the endothelial cell lining and impair the vascular system, coagulation mechanism, and immune system. These endotoxins also trigger the immune and inflammatory responses, which results in the activation of macrophages and CD4 cells that release proinflammatory cytokines to create a systemic inflammatory response to the pathogen. Hospitalized patients may quickly progress from bacteremia to sepsis and finally to septic shock, even with treatment.

Is aggressive widespread inflammatory response to infection (sepsis) or perceived invader. Also, ischemia, infarction and injury.

Sepsis is defined by the Surviving Sepsis Campaign (SSC) as “the presence (probable or documented) of infection together with systemic manifestations of infection” (Dellinger et al.,

Sepsis is a rapidly progressive illness that must be treated early with antibiotics and supportive care.

Septic shock results from bacteria that multiply in the blood and then releases toxins that decrease blood pressure, thus, impairing blood flow to cells, tissues and organs. It is an acute infection, usually systemic, that overwhelms the body (toxic shock syndrome) (Huether & Mccance, 2012). This

Diagnosing the disease can be relatively simple, but this depends on accurate patient history and ones ability to recognize varied clinical signs and then perform diagnostic procedures. These diagnostic procedures may include antigen testing, x-rays, ultrasonography, angiography, a complete blood count, the Knott’s or Filter test, and in the worst case necropsy.

Sepsis is a substantial health care condition. Jones et al. (2016) describes sepsis as the “11th leading cause of death in the United States ranking 10th in people 65 years of age and older” (p. 122). This impact of mortality from sepsis is devastating to many families in the United States. Facing the health care system also is the cost of septicemia. Septicemia was the most costly and most common reason for hospitalization, as reported by Jones et al (2016) “accounting for 1,094,000 hospital stays and $20.3 billion in aggregated hospital costs, the average cost for an admission for sepsis at $18,600” (p. 122).

Sepsis is the body’s response to infection. The onset of sepsis is often undetected until the condition has become critical. Sepsis progresses into severe sepsis, septic shock, and eventually death; typically from organ failure. The condition affects over 500,000 individuals annually, has a mortality rate of over 25%, and presents a risk to patients in every inpatient setting regardless of acuity level (Whelchel et al., 2011). My first experience with sepsis was enlightening because it affected a patient under my care. I was surprised at the insidious onset of the symptoms, the rapid decline in the patient’s condition, and the missed opportunities that the healthcare team had to implement the recommended care bundle protocols.

1. Sepsis is a complex immune disorder that is characterized by systemic hyper-inflammation. Where multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis pulmonary infection with Francisella novicida, a Gram negative bacterial pathogen.

Severe Sepsis affects 750,000 Americans and causes more than 200,000 deaths annually. Sepsis is a complex condition that results from an infectious process that represents the body's response to infection and involves systemic inflammatory and cellular events that result in altered circulation and coagulation, endothelial dysfunction and impaired tissue perfusion (Kleinpell, 2005). Associated mortality rates with sepsis in the United States have remained largely unchanged for several decades. Through an international collaboration known as the

Pediatric sepsis can present itself in a number of ways, it is manifested by: rashes, changes in skin color, decreased amount of urine, lethargy, fever above 1004 F, and disinterest or difficulty feeding, among others (Rory Staunton Foundation for Sepsis Prevention, n.d.) When sepsis takes place, the circulatory system is often the first system to become compromised. Tachycardia, tachypnea, peripheral vasodilation, fever, or worst case scenario, circulatory collapse can happen (Santhanam, 2016). If continued, sepsis can eventually affect multiple organs, also known as multiple organ dysfunction syndrome (MOBS), or worse lead to death. The signs and symptoms of sepsis reflect the systemic inflammatory response syndrome (SIRS). As medical doctor Shankar Santhanam (2016) states in the “Pediatric Sepsis,” SIRS can be caused by infectious or

There are many complications that can occur from other illnesses and in all attempts, the healthcare team tries their best to prevent these complications in every circumstance as possible. One of these complications that can arise from an illness including sepsis. Sepsis is known as a systemic infection that is located within the blood and can invade every organ and tissue in the body. If the infection is not treated in time or cannot be controlled, it can progress to septic shock and eventually to multiple organ dysfunctional syndrome. Sepsis is a serious infection and the mortality rate has increased by 50% due to a delay in seeking medical attention with an infection (Davis, 2014).

Sepsis can develop into septic shock which is the point where the patient’s blood pressure drops to a dangerous level due to the presence of bacteria in the body.

An individual can get a septic infection from many sources, such as surgery, burns, injury, etc. The infectious source can be bacterial, parasitic, viral, or fungal. According to Bernstein& Lynn (2013), Systemic inflammatory response syndrome (SIRS) is a clinical syndrome that manifests itself as an acute, nonspecific illness. Sepsis is the first stage of the infection and it manifest itself in many ways, such as an 100.4F or below 96.8F body temperature, white cell count below 4,000 cells/mm3 or, or greater than 12 cell/mm3. If sepsis is not stopped early in its tracks it can lead to sever sepsis which causes acute organ dysfunction, organs such as the kidneys, lungs and heart. If the severe septic infection gets worse, it can lead to the life threating infection, septic shock. Septic shock will reduce the blood