Severe Plaque Psoriasis Case Studies

Kathryn is an 89-year-old female who suffers from plaque psoriasis (L40.0), along with diabetes. Her symptoms include dry, itchy, extremely bothersome plaques located on her lower extremity and groin area. Kathryn has tried and failed various treatments including clobetasol and betamethasone, which has provided her with little to no relief. She is not a candidate for the multiple biologic therapies due to the risks of infection and malignancies are too high for Kathryn to risk taking these medications. Otezla is an anti-inflammatory drug that works through the intracellular inhibition of phosphodiesterase 4 (PDE4) resulting in the increase of intracellular cAMP levels. Otezla does not carry the extreme warnings for serious infections and malignancies

Brian is a 29-year-old male who suffers from plague psoriasis (L40.0). His symptoms include scaly, red, moderate in severity plaques located on his feet, hands, trunk, and scalp, in addition to plaque psoriasis he also suffers with arthritis. He experiencing sever fissuring and pain with walking and daily functioning. Brian has tried and failed various treatments including clobetasol, and keralac, both provided him with little to no relief. Otezla was denied for requiring a three-month trial of light therapy, however, he is not a candidate for light treatment due to his work schedule. Otezla was approved for moderate to severe plaque psoriasis by regulating inflammation within immune cells without said side effects or risks. By helping to

Brian is a 27-year-old male who suffers from plaque psoriasis (L40.0). His symptoms include red, itchy, flaking plaques located on his scalp, genitalia and legs with a BSA of 11%. Brain has tried and failed various treatments including triamcinolone and fluocinolone, both provided him with little to no relief. Brian is not a candidate for said biologics, because they can raise the risk of possibly fatal infections, Lymphoma, and other malignancies. I believe those risks of infection, malignancies are too high for Brian, in addition to both Humira, and Enbrel suppresses the immune system. Systemic medications are also too much of a risk for Brian because they have adverse side effects, which can also be extremely fatal and he is still of

Cindy is a 55-year-old female who suffers from plaque psoriasis (L40.0), along with psoriatic arthopathy. Her symptoms include severe, itchy, painful plaques on scalp and ears, along with painful joints that are swollen, and inflamed. Previously, Cindy has tried and failed various treatments including clobetasol and Taclonex, with little to no relief. Your denial indicates that Cindy is to have an inadequate response, contraindication, documented intolerance to Systemic therapy (Methotrexate, Cyclosporine, or acitretin), or UVA/ UVB phototherapy. Systemic medications are also too much of a risk for Cindy because they have adverse side effects, which can also be extremely fatal. She is also not a candidate for Phototherapy due to the severe

If you have an itchy rash on your feet, your first thought may be that you have athlete's foot. However, another cause could be psoriasis. Some people with psoriasis get it on their feet. It is commonly on the soles of the feet, but it can be on the toes or top of the feet too. Psoriasis is a bothersome skin condition. Your skin can crack, become scaly, itch, and burn. It becomes uncomfortable to wear shoes and you might even have trouble walking. If you have a rash or scaly lesions on your feet, you should see a podiatrist for a diagnosis. These are some treatments you might try if you suffer from psoriasis.

Researchers examined 132 psoriasis patients whose psoriasis had completely cleared with anthralin therapy and were followed over 3 years. Fifty-one patients (39%) recalled specific

Psoriasis is an irritating skin disease that primarily affects the scalp and extensor surfaces of the knees and elbows, though it can develop anywhere in the body. It is characterized by patches of abnormal skin that are typically red, itchy and scaly. It occurs when the reproduction of basal cells which are set at the bottom of several layers of cell and from which the skin growth increases dramatically. The upper layer of skin cannot shed the dead cells at the same rate and this scaly build-up occurs. The increase in basal cell production is believed to be caused by an imbalance of 2 natural chemical complexes called cAMP, which inhibits cell growth and cGMP which encourages cell growth. Proteins and toxins from bacterial and yeast metabolism

Males and females are equally affected by psoriasis vulgaris. Many studies indicate that age of onset is younger in females. Thus, one German study demonstrated an age of onset of 22 years in males and 16 years in females in early onset disease (Henseler and Christophers, 1985). However, results of studies are highly dependent on sampling techniques used and are variable in their results. There is no an approved evidence that the disease is phenotypically different between the sexes.

Psoriasis is a long term condition affecting 2-3% of the population. Psoriasis is patches of red, itchy, and scaly skin that varies in size. Psoriasis typically occurs on the knees, elbows, and scalp. There are different forms of psoriasis such as pustular psoriasis, guttate psoriasis, inverse psoriasis, and erythrodermic psoriasis. In mild cases, the skin is itchy,red, and irritated. In severe cases, the lesions may be painful to touch, begin to crack, and bleed. People with

Dithranol (anthralin) [1,2]
 The role of salicylic acid in stabilizing dithranol formulations was an accidental discovery, and led to the development of the Ingram regimen [5], which has played a central part in psoriasis management since, especially in Europe. After a tar bath in which scales and the previous applications are removed, sub erythema UVB is given, and the lesions then precisely covered with dithranol paste. The initial concentration is 0.05 or 0.1%, increasing cautiously up to 4% according to response, and aiming to avoid irritation of the normal or psoriatic skin [5–7].

Psoriasis is one of common skin problem in which life cycle of skin cells speed up. It leads to creation of patches that may vary in size from time to time which can be itchy and painful. It is a continual skin problem that often comes and goes. Exact cause of psoriasis is still a mystery. It can be caused by known as well as unknown factors. Various environmental elements act as causes of psoriasis. Such factors include bug bites, sunburn, stress, cold weather, smoking, heavy alcohol consumption, etc (Cole, n.d). Use of various drugs such as Plaquenil, Quinacrine, chloroquine, hydroxychloroquine, Inderal, quinidine and indomethacin also may trigger psoriasis. Psoriasis classically presents as large plaques with scale but there are also other forms of psoriasis which need to be considered. Major symptoms of psoriasis includes red patches of skin covered with thick, silvery scales, small scaling spots, dry and cracked skin that may bleed, itching, burning or soreness, thickened, pitted or ridged nails,

The cause of psoriasis is you immune system is overworking itself. Which is causing your skin cells to build and cause these dry, annoying skin patches. This is causing plaque in the skin. Psoriasis is unknown but people believe that it has multiple problems with the immune system, including IL-17A, this can cause inflammation on the skin and cause the plaque in the skin to start too grown and worsen.

Psoriatic arthritis is a type of arthritis that can develop in some people who experience the skin condition psoriasis. There are five main types of psoriatic arthritis- Symmetric arthritis, Asymmetric arthritis, Digital Interphalangeal Predominant (DIP) arthritis, Arthritis mutilans and Spondylitis. In this article we will examine treatments available.

This study was performed at Menoufia University Hospitals to determine the serum levels of IL‑22 in patients with psoriasis and to correlate those levels with PASI score. The present study included 60 subjects divided into two groups: 40 patients with psoriasis and 20 healthy controls. All patients and controls were clinically evaluated, and blood samples were collected for detection of serum IL‑22 by the ELISA technique. In the patient group, 23 were males (57.5%) and 17 were females (42.5%), with a mean age of 39.70 ± 16.68 years, whereas in the control group, nine were males (45%) and 11 were females (55%), with a mean age of 33.50 ± 14.94 years, with no significant differences between the patient and the control groups regarding both

The patient has history of psoriasis diagnosed when she was in middle school. Last year, in 2014, she underwent light therapy with a dermatologist in Exeter with Northeast Dermatology Associates and that seemed to help significantly. She now has just one spot on her left leg that she is using no treatment for. She would rather not use a treatment if she does not need to.