Sexualy Transmited Diseases: Hemophilia Essay

The genetic disorder of Hemophilia is where the clotting factors of the blood are absent or deficient, causing it to be a dangerous disorder to the people who have it. This disorder is where the people who have it will bleed easily and accessibly. Different types of hemophilia are classified by different deficient clotting factors in the blood. Treatments for hemophilia are available, including transfusions of frozen

Hemophilia is a rare genetic blood clotting disorder that primarily affects males. People living with hemophilia do not have enough of, or are missing, one of the blood clotting proteins naturally found in blood. Two of the most common forms of hemophilia are A and B. In persons with hemophilia A (also called classic hemophilia), clotting factor VIII is not present in sufficient amounts or is absent. In persons with hemophilia B (also called Christmas disease), clotting factor IX is not present in sufficient amounts or is absent. People with hemophilia do not bleed more profusely or bleed faster than normal; they bleed for a longer period of time.

If a mother is recessive for hemophilia and passes her X chromosome to her son; that son will most likely have hemophilia. Meaning that the rates of hemophilia among males are more common than among females. Reason being is that while a female has two X chromosomes a male only has one. The only chances of a female being hemophilia is both X’s have that gene. If a male has hemophilia and reproduces his daughter will no doubt be at least a carrier for hemophilia. Hemophilia breaks into 3 categories severe, moderate, and mild. About 1% of everyone who has hemophilia will go through severe symptoms (internal bleeding, joint spontaneous bleeding etc.) Moderate is about 1-5 and mild is about the rest. Symptoms of hemophilia include cuts lasting longer, and wounds take longer to close. However in more severe cases, patients can have spontaneous internal bleeding in the joints. Without surgery and the proper procedures, this can lead to death. People who have hemophilia are usually diagnosed within the first year. Doctor’s test patience through taking a blood sample, and seeing how much of factor 8 or 9 there is. Doctor’s also see if there's any history of hemophilia in the

A large number of mutations for Hemophilia A have been detected and identified. The most common mutation found is the intron twenty-two inversion and intron one inversion of the Factor VIII gene. This mutation occurs in 40-50 percent of people with Hemophilia A. It is caused by the homologous recombination between copies of a DNA sequence. One copy is located on the intron 22 region of factor VIII and the other copies are distal to the factor VIII. Intron one of the factor VIII gene occurs when the factor VIII gene is split which results in the production of two chimeric mRNAs. One of the mRNA has have the exon of the factor VIII and the exons 2-6 on the exon gene of the VBP1 gene, which codes for the subunit of prefolding. The second mRNA has all exons except the last exon of the BRCC3 gene. Other patients that have Hemophilia A acquire the

As previously mentioned, hemophilia A varies in severity, which in turn includes symptoms (Iorio et al., 2010). Obviously the main symptom is excessive bleeding. Usually, hemophilia A is first noticed when an infant is circumcised (Iorio et al., 2010), however milder cases of hemophilia can be noticed later in life. If this is the case, mild cases can go unnoticed until after a surgery or injury in which internal bleeding would be a problem (Iorio et al., 2010). In addition, victims of hemophilia are recommended to get a hepatitis B vaccine due to the fact that they may receive blood products (Iorio et al.,

Hemarthrosis is a characteristic of hemophilia symptom which is more severe when the knees and ankles are mostly affected. The bleeding will cause swelling of the joint spaces, sometimes one particular joint, called a target joint, that will tend to bleed most often, significant pain in joints and over time, the joints can be disfiguring.

Hematuria is one of the signs occurring in patients with severe hemophilia A. A typical sign is change of urine color, which depends upon extent of bleeding and could be brownish or reddish in color. Common source of bleeding is

You mentioned hemophilia so I just wanted to explain what it was. Hemophilia is an inherited disease that affects the clotting process of your blood. Therefore, if you have hemophilia you do stand a chance of sever bleeding if you incur an injury or cut. There is a protein that is called clotting factor that a person might have little or none at all. It is a protein used for blood clotting that helps blood platelets stick together. (NIH

Hemophilia is a rare disorder when blood doesn't clot normally because it is short on sufficient blood-clotting proteins. Deep bleeding inside the body is big concern especially in the knees, ankles and elbows. The internal bleeding caused from this can damage the organs and tissues of the body and may be life threating. When a person without Hemophilia is injured, a system of procedures happens to make the blood turn from liquid to solid to clot the wound and make the blood flow stop. Platelets, which are cells found in the blood, combine together to form a clot at the site of bleeding. The platelets hold an enzyme that causes fibrinogen to change to fibrin which is a solid substance that doesn’t liquefy. The fibrin goes to the area of injury

When he was three days old his doctor diagnosed him with severe type A Hemophilia after a circumcision

This kind of bleeding is very painful and may lead to joint deformity and arthritis. As the person with hemophilia experiences episodes, they are better to identify “a bleed” before there are any outward signs. For instance; As blood collects in the joint or muscle space, they may notice warmth, pain, and/or swelling to the area affected. For an infant or toddler the caretaker may notice some signs and symptoms suck as, swelling and warmth to an area of the body, blood in the urine or stool, unexplained irritability, or pain (“hemophilia”2002).

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

A. It 's important to know that hemophilia is not actually a disease or virus. https://my.clevelandclinic.org calls hemophilia "a rare hereditary (inherited) bleeding disorder in which blood cannot clot normally at the site of a wound or injury". This means that it is not contagious, rather it is passed down through genetics. When a hemophiliac gets injured,

Hemophilia like many diseases doesn't have a cure at the moment. There are treatment plans available. A doctor will prescribe transfusions usually. Factor replacement therapy injects the missing factor into the system which immediately provides the missing blood clotting factor the afflicted person is missing. These transfusions can be made from human blood or blood from an animal. When the transfusion is from a human, the proteins extracted for the transfusion are sterilized to prevent any blood related diseases. When the transfusion is taken from an animal, the factor desired to be produced is injected into the animal, so it can then produce large amounts of it. After that, the factor is extracted and it is then stabilized so it can be used in humans. The reason why a doctor must be seen for hemophiliacs to be treated is that, hemophilia varies in severity from case to case. This is because every person produces a different amount of the blood clotting factor. One hemophiliac may produce 15% of what a normal person produces while another hemophiliac may produce only 1% of what a normal person produces (HoG) . The amount and regularity of transfusions depend on severity of

Hemophilia is a problem with the blood in a person that causes them to bleed not any faster than normal, but they often bleed for a longer period. Their blood is missing the clotting factor (a protein in the bloodstream that works to control bleeding). Hemophilia is quite rare; roughly 1 in every 10,000 persons are born with it. Rarely, hemophilia can be an acquired disease which just means a person is not born with it, but will develop it during their lifetime. This rarity occurs when a person's immune system forms antibodies that attack the clotting factor in the blood. The entire antibody population fights against the blood to prevent the clotting factors from working properly.