Sickle Cell Anaemia Essay

People suffering from sickle cell disease has haemoglobin S replacing at least one of the beta-globin tertiary subunits in haemoglobin. In the case of sickle cell anaemia, both beta-globin subunits are replaced by haemoglobin S. There are other types of sickle cell disease in which one beta- globin is replaced by haemoglobin S and the other replaced by haemoglobin C which is another type of mutation variant of the beta-globin subunit of haemoglobin.

Sickle cell disease is a disease that is most prevalent in people of African descent along with people of Mediterranean and Middle Eastern origin. This disease is known to affect about 70, 000 Americans and about 2 million people carry the trait (meaning that, they carry a single gene mutation).

Sickle Cell Disease is an illness that affects people all across the globe. This paper will give a description of the sickness through the discussion of the causes, symptoms, and possible cures. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia.

Sickle Cell Anemia is a horrifying, scary disease to have. Sickle cell anemia is a blood disease that is inherited. It comes from substitutions between a single amino acid and a component protein of hemoglobin. Globin, which is the component protein that has the substitution, isn’t effective. When someone has sickle cell, hemoglobin molecules with those component proteins, stick together and make strands of hemoglobin in red blood cells. Cells with that strand end up stiff and long, known as sickle shaped. Also, with sickle cell, those cells die faster than normal red blood cells and they aren’t easy to replace in a fast manner. Anemia within itself is when there is a huge shortage of red blood cells. When you think about the disease and

Sickle cell disease is a hereditary blood disorder caused by an abnormal hemoglobin in the red blood cell. Hemoglobin is a type of protein that carries oxygen in the body. In order for someone to have sickle cell disease they would need to have been passed down from at each one of their parents, by inheriting a total of two hemoglobin genes. The fact that this is a hereditary disease means that it is not considered to be contagious. This disease comes in about six different forms, but the most severe of them all is sickle cell anemia. Sickle cell is an inherited disease that affects the red blood cells causing debilitating symptoms, however, with treatment people with this disease can quite possibly live an otherwise

Sickle cell trait is the heterozygous state of the sickle cell gene, also called sickle hemoglobin (HbS) (DynaMed, 2015). The sickle hemoglobin (HbS) is an abnormal hemoglobin resulted from an atypical mutation of a normal hemoglobin. Heterozygous individuals are carriers of the sickle cell trait, and they are usually asymptomatic (DynaMed, 2015). There are no interventions or referral indicated for infants. The risk factors for sickle cell gene include ancestry from Africa, Caribbean, Central and South America, India, Mediterranean, and the Middle East (DynaMed, 2015). Although Sickle cell trait is a benign condition, studies have found that under extreme conditions such as severe

Sickle Cell Disease (SCD) and Thalassemias are similar blood disorders with some important differences. Sickle Cell Disease is a disorder where the red blood cells are sickle-shaped, which causes them to stick to vessel walls preventing much needed oxygen from traveling through the body. Thalassemias has normal looking red blood cells, but the body does not make enough healthy cells or hemoglobin. This means there is a lack of oxygen because the body does not produce enough blood or hemoglobin to carry it throughout the body. The two diseases have basic similarities reflected by the concepts regarding diagnosing and treatment plans. They also differ in many ways; for example, Sickle Cell consist of more complications than the Thalassemias disorder. Thalassemia, however, affects more ethnic backgrounds and numbers of the afflicted are spread over a greater geographical area.

Sickle Cell anemia is a group of inherited red blood cell disorders, or a collection of recessive genetic disorders characterized by a hemoglobin variant called Hb S. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long hard rods in the red cell when it gives

Sickle cell crisis is an acute form of sickle cell disease where pain and sickling are extensive (Byar, 2013). SCD is a genetic disease that predominantly affects black people of African decent (Gersten, 2016). Abnormal hemoglobin chains are the main issue with SCD (Byar, 2013). Normal hemoglobin chains are comprised of 99% hemoglobin A (HbA) however, in SCD an abnormal form of the gene, hemoglobin S (HbS) is present in approximately 40% of total hemoglobin (Byar, 2013). In order for a person to be born with SCD, both parents must carry the abnormal gene, HbS (Byar, 2013). HbS is extremely sensitive to the changes in oxygen amount of the RBC and when exposed to decreased oxygen the HbS cause the RBC to distort and become sickle-shaped,

This mutation paper is to give information on the Sickle Cell disease. This is a negative disease to have because the Sickle Cell Disease decreases the health of the person that has the disease and limits what they can and cannot do. Sickle Cell Disease is a red blood cell disease that causes ab normal hemoglobin to from in the veins. Hemoglobin is the protein that carries oxygen throughout the body to help with the respiratory system. The cause of the genetic mutation is inheritance or getting the disease from the parents the disease is found on chromosome 13 while the hemoglobin is still in beta phase on gene HB A. The disease typically shows symptoms within the first 5 to 6 months of birth and being diagnosed with Sickle Cell Disease. The symptoms include painful swelling on the hands and feet, and Jaundice, which causes a white color to form under the eyes, and turns the skin color yellow.

In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid "sickle" shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking to form a helical shape. Once this happens the cells cluster together and elongate and the cells start to "sickle". A person who has sickle cell anemia can only get it if both of their parents carry the sickle cell trait, if only one parent has the trait then there children are at risk for having the trait.

Sickle cell anemia (SCA) is an autosomal recessive genetic disorder. This missense mutation is characterized by mutant beta globin subunits that tend to stick together (Cummings, 2014). As a result, abnormally shaped red blood cells are produced by this disorder. The erythrocytes are sickle or crescent shaped. Sickling occurs under hypoxic conditions, in which there is insufficient supply of oxygen delivered throughout the body (Sun & Xia, 2013). In order to inherit this monogenic disease, one copy of the sickle globin gene from each parent must be passed on to the offspring (Ashley-Koch,

Sickle Cell Anemia is a genetic disorder dealing with the hemoglobin within the red blood cells the individual has hemoglobin S (1). This causes the red blood cell to become gelatinous when deoxygenated (2).

Sickle cell disease (SCD) is an inherited and noncontagious, lifelong condition. More specifically, per Ohaeri, Shokunbi, Akinlade, & Dare, 1995, SCD is a generic term for a group of genetic disorders characterized by the predominance of sickle cell hemoglobin (Hgb). Hemoglobin is a protein in the red blood cells that carries oxygen throughout the body. The disease produces significantly abnormal Hgb molecules in red blood cells (RBCs). In sickle cell anemia, the red blood cells become rigid and sticky and are shaped like sickles or crescent moons. These irregularly shaped cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body (Ohaeri, Shokunbi, Akinlade, & Dare, 1995, p. 955.Individuals

Sickle cell disease is a hereditary blood disorder most common in the African American community. Many people are carriers of the sickle cell trait, however in order for a person to develop sickle cell disease both parents must have passed on the trait to their child. Sickle cell disease causes a mutation in normal red blood cells resulting in decreased tissue perfusion and organ damage. This causes partial or complete replacement of normal hemoglobin with abnormal shaped sickled cells. An abnormal shaped sickled cell may become lodged to a blood vessel where other cells then bind to it and begin to form a clump. The blood vessels continually attach to each other and result in a blockage of small blood vessels eventually resulting in organ