Sickle cell anemia affects a wide range of demographics, from young to old. However, there are specific groups of people who are likely more prone to this disease than any other group. This disease affects millions of people worldwide regardless of age, but it is particularly common amongst those who derive from specific regions of the world. Sickle cell anemia is most common in those whose ancestors are derived from the sub-Saharan region of Africa. Furthermore, other regions that are known to have a high number of people containing sickle cell anemia are from Mediterranean countries, the Arabian Peninsula, and Spanish-speaking regions as well ("Who Is at Risk for Sickle Cell Anemia?"). This disease originated from the sub-Saharan region of Africa, and later migrated to other areas through the spreading of other diseases such as malaria. This is due to the fact that sickle cell disease occurs habitually in areas that are prone to diseases such as malaria. Although this disease can affect anyone, the highest cases of sickle cell anemia were found in African-Americans than in any other race. In the United States, sickle cell disease affects about 70,000 to 100,000 Americans ("Who Is at Risk for Sickle Cell Anemia?"). The statistics show that 1 out of every 500 births is affected by sickle cell disease for African-Americans. For the Hispanics, 1 out of every 36,000 births is prone to sickle cell disease ("Who Is at Risk for Sickle Cell Anemia?"). The age ranges for which a
Now that the disease is more clearly defined, we must ask, why did this illness come about? This is one of the most interesting facts about Sickle Cell. Since the trait originated in countries that were ravaged by malaria, it could be said that this trait evolved to fight the deadly mosquito-spread disease. "People with sickle trait were more likely to survive malaria outbreaks in Africa than those with normal hemoglobin, it is
Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).
Sickle cell disease is a disease that is most prevalent in people of African descent along with people of Mediterranean and Middle Eastern origin. This disease is known to affect about 70, 000 Americans and about 2 million people carry the trait (meaning that, they carry a single gene mutation).
It has always been assumed that genetics and lifestyle play a major role in the presence of health disparities and health care issue that affects African-Americans. This paper provides a historical background to a key disease more prevalent in the African American community, Sickle Cell Anemia, the history behind the disease, genetic mechanisms that influences once probability of inheritance and in-depth treatment on how to manage, prevent and sustain a healthy lifestyle when dealing with sickle cell anemia. Sickle cell anemia is a hereditary disease that alters important aspects of the body physiologically and can be inherited via genes. Sickle cell disease (SCD) was first identified in 1910 and has existed in the continent of Africa for five
In conclusion, sickle cell anemia and the sickle cell trait are more common in African-Americans and people who live in places where malaria is common. Individuals with the trait seem to live normal and healthy lives, however individuals who have the trait and experience high altitudes or vigorous exercise tend to feel unwell because of the lack of oxygen getting into the cells causing them to sickle. In addition, the sickling of the cells can be reversible to a certain extent in people with the trait, however people who have sickle cell anemia the sickling of the cells is irreversible due to the severity of the disease.
Sickle cell disease (SCD) occurs in 1 out of every 365 African American births compared to 1 out of 16,000 Hispanic-American births (1). SCD is a group of red blood cell disorders in which patients have a sickle or moon-shaped red blood cell due to an abnormal S hemoglobin. While sickle cell disease is relatively rare in American births, this is an alarming statistic among people of Sub-Saharan (west and central) African descent. An interesting fact is that SCD occurs more often among people from parts of the world where malaria is or was common, such as Sub-Saharan Africa (1). In addition, it is believed that people who carry the sickle cell trait are less likely to have
Cuba is located in Central America and the Caribbean. The type of government Cuba has is a communist government, so the government plans and controls the economy. The top three exports for Cuba are NESOI items, pharmaceuticals, and tobacco. The top three imports are machinery, fuel, and tobacco. Cuba's GDP goes up about 3% annually and overall, Cuba's government is steadily increasing each year. The population in Cuba is 11,027,000. Cuba’s health per capita is roughly $1,828. Cuba is a multi-ethnic nation, home to people of different ethnic and national backgrounds. The majority of Cubans descend from spaniards.
This paper will discuss Sickle Cell Anemia. It will describe what the disease is as well as how its contracted. The paper will go on to on to discuss the symtoms risk and statistics of sickle cell aniema. The paper will end with discussing treatment for the disease.
Sickle cell anemia is more common in sub-Saharan regions of Africa, where malaria is prevalent, than it is in regions where malaria is not common. This is because being heterozygous for sickle cell anemia in malaria-prone regions carries a fitness.
Sickle Cell Anemia Disease is an inherited disease that turns healthy red blood cells (donut shape) into abnormal sickle shaped red cells which affects people's hemoglobin (a red protein responsible for transporting oxygen in the blood) (Naoum). This disease gets its name from the shape of red blood cells under low oxygen condensation which becomes sickle shaped. These sickle shaped cells get stuck in small blood vessels which causes people with this disease to have oxygen blockage (fudge foundation). People inherit this disease from their parents, if both parents have a trait of sickle cell anemia (people who inherit one sickle cell gene and one normal gene, they have a 25 percent chance of having an unaffected
Scientist explained the difference between Sickle Cell Disease in Africa to Sickle Cell Disease in United States by showing how common this disease is in Africa than it is in the United States. Scientist believe that in Africa there is a fatal form of malaria that occurs in Africa. People who have homozygous for the normal allele for hemoglobin often die of malaria. But people who have sickle cell trait don’t come in contact with the fatal form of malaria. Then more heterozygous live then people with homozygous for the normal allele, and they pass it to their children and their children gets sickle cell disease. Sickle Cell disease is not that common in the United States because people with sickle cell disease often died in early childhood and thus, many people didn’t pass it on to their children. Instead most inheritance from the alleles is from a parent who is heterozygous for the allele to one or more of his children.
Thousands of years ago, a genetic mutation occurred in people from the Mediterranean basin, India, Africa, and the Middle East. As the Malaria Epidemic attacked people of these countries, carriers of the defective hemoglobin gene survived. Carrying one defective gene means that a person has a sickle cell trait. Two parents with the trait will produce a child with sickle cell anemia. People of these countries migrated and spread to other areas. In the Western Hemisphere, where malaria is not much of a problem, having the abnormal hemoglobin gene has lost its advantage. Any child born from parents that each has the trait will be born with the disease.
Sickle-cell disease majorly affects the hemoglobin that is present in our blood. The job of hemoglobin is to help transport oxygen and carbon dioxide to and from the cells throughout our body. Hemoglobin is present specifically in our red blood cells. Each red blood cell contains two hundred and eighty million hemoglobin molecules. Red blood cells normal shape is a biconcave shape because of the lack of many organelles and a nucleus. The shape is so important to a red blood cells functioning that if it is not shaped normally it has major consequences. The shape helps them to fit through capillaries easier and also allows for an increased surface area which results in easier gas exchange. Sickle-cell disease is a genetic disease that causes issues in the oxygen/carbon dioxide carrying hemoglobin molecules that are present in our red blood cells.
Sickle cell anemia is an anemia that is inherited and mostly affects people whose heritage can be traced back to places where malaria was prevalent. There are approximately 100,000 Americans that have the disease and many more with the trait. Several of my family members are afflicted by this medical condition that causes red blood cells to take on an irregular shape.
Sickle cell disease is a genetic disease that caused by abnormalities in the production of hemoglobin of red blood cells, characterized by its sickle-like shape. While the main function of hemoglobin in red blood cells is to carry oxygen to different parts of the body, these sickle cells are unable to perform this task adequately. The sickle shape of these red blood cells contributes to lower blood flow through vessels as they begin to build up and block passage through smaller blood vessels (“Facts About Sickle”). Although there are several types of sickle cell diseases, the most severe and common form is sickle cell anemia. Sickle cell anemia is a form of this disease where a child inherits one sickle cell gene from each parent and therefore