Sickle Cell Anemia Disease

Sickle Cell Anemia is a very serious disorder and people suffer from it every day. It is a genetic disorder that causes the hemoglobin in the red blood cell to distort and form into a sickle like shape. The name comes from the shape of the blood cell after it is mutated. A person who has sickle cell anemia got it from inheriting from the parents. It is the most common inherited disorder in the United States. It is also has four other names this disorder can go by HbS, Hemoglobin S Disease, SCD, and Sickle Cell .(https://ghr.nlm.nih.gov)the blood cell is formed wrong turning it into a sickle or crescent shape. Sickle cell is only a disorder. It can also be treated a lot of different ways.

Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape

Sickle Cell anemia is a group of inherited red blood cell disorders, or a collection of recessive genetic disorders characterized by a hemoglobin variant called Hb S. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long hard rods in the red cell when it gives

In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid "sickle" shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking to form a helical shape. Once this happens the cells cluster together and elongate and the cells start to "sickle". A person who has sickle cell anemia can only get it if both of their parents carry the sickle cell trait, if only one parent has the trait then there children are at risk for having the trait.

Sickle cell anemia (SCA) is an inherited blood disease which causes normal, round, healthy red blood cells to transform into sickle-shaped cells. Normal red blood cells are flexible and can easily pass through capillaries to bring oxygen to different parts of the body. However, sickle cells are fragile, and can easily die, leading to anemia (red blood cell deficiency). SCA can also cause blood vessel occlusion (blockage of blood vessels), tissue infarctions (death due to lack of oxygen), bone, joint, and abdominal pain, yellow eyes and skin, pale skin, delayed growth, increased risk of infections, and damage to organs. The disease is passed on by autosomal recessive inheritance, which means both parents of a child must have the defective gene for the child to be affected. If only one gene is inherited, the victim becomes a carrier of the sickle cell trait, producing only some sickle cells with little or no symptoms. This means two people with the trait have a 25% chance of having a baby with sickle cell disease, 25% chance of them having no defects, and 50% chance of the baby becoming a carrier as well. When the gene is inherited, it mutates the beta (β) globin gene in chromosome 11, changing the hemoglobins produced using instructions from the gene from a healthy hemoglobin A (Hb A) to a mutated hemoglobin S (Hb S). Many tests can be done to check for sickle cell disease, the most common being an ordinary blood test, where the blood is examined for hemoglobin S. If the

The diagnosis for the disease is straightforward. All states screen newborns for sickle cell. This can be done by a simple blood test. The treatment for sickle cell anemia is minimal. There are no cures for the disease. However treatments and pain killers can help with some of the symptoms. There are a few environmental factors of sickle cell. For example people with the disease should avoid cold areas so that their blood flow stays normal. They should also make sure that they have good circulation at all times to ensure that the blood is moving. All in all, sickle cell is a simple disease that does not take much to deal

Sickle Cell Disease is a genetic disease. If you have the disease, you have a lower life expectancy while you are also given a tremendous amount of pain to endure. The disease is inherited and it also causes a mutated hemoglobin. When you have this disease, instead of your red blood cells being circular like a moon it is much smaller like the shape of a crescent moon. Our red blood cells

But what does this mean, well first a mutation is an abnormality much in the way that cancer is an abnormal growth within the body. These are mutations, unfortunately we don’t get the same types of mutations that the X-Men have. Our body’s are made so that everything perfectly fits in each hole or socket, well red blood cells are normally round and smooth. Red blood cells are designed to be able to flow smoothly through blood vessels which is why they are smooth and round. Like mentioned earlier Sickle cell anemia is a mutation of the hemoglobin or the blood cells themselves. The blood cells stack on one another into long tube like structures. The cells become sickle shaped and become rigid. The sickling starts on the chromosome 11. While the cells are stacking up they are damaging vital organs such as the lungs and the heart. Everyone gets a copy of the hemoglobin gene from each parent. If both genes are carriers of the sickled trait, there will be high probability that the offspring will have Sickle cell anemia. Sickle cell is not contagious and cannot be caught, it is passed along genetically. Through research we have found that there are different types of the sickling disease. There is Hemoglobin SS (Sickle cell anemia), hemoglobin SC and hemoglobin sickle betathalassemia which is known as Mediterranean

Sickle cell anemia is a disease that is found in about seventy thousand to one-hundred thousand people in a year here in the United States, most commonly found in African-Americans. This disease occurs in the blood where the hemoglobin attaches itself to the oxygen in the lungs and then carried all throughout the body. When this occurs the red blood cell is changed to rigid and the shape turns to a “C” (A.K.A. Sickle) which is where the disease got its name. The C like cell may get stuck and block blood flow to vital organs which can cause a stroke, acute chest syndrome, organ damage, and other disabilities. Sickle cell is unfortunately an inherited disease which is either passed down by both parents or if one parents has the trait and the

The deformity caused by sickle cell anemia results in a decreased oxygen carrying capacity by the cell, and that leads to a variety of related issues. Additionally, the lifespans of sickle cells are shorter than the lifespans of regular red blood cells, because sickle cells are brittle and break apart easily. On the macroscopic level, symptoms for sickle cell anemia vary for age. A common symptom for infants is swelling in the hands and feet, often referred to as hand-foot syndrome. The swelling is a result of blood flow back to the heart being blocked by clusters of sickle cells. Perhaps the most common and widespread symptom is chronic pain. The pain occurs because the sickle cells obstruct the flow of blood to miniscule blood vessels leading to the chest, abdomen, and joints. These episodes of pain, called crises, vary from individual to individual. Some individuals experience only one or two crises in a year, and others suffer from dozens. The crises also vary in intensity and duration. While less common than crises, sickle cell anemia also leaves many crippled with infections because the liver, an organ that helps combat infections, can become damaged or destroyed by sickle cell anemia. Other, less common, symptoms and side effects of sickle cell anemia include vision problems, jaundiced eyes,

Jaundice can cause a person’s skin and whites of the eyes to develop a yellowish tint. It is also common for people with sickle cell anemia to have a hard time fighting infections. Teens with sickle cell anemia grow more slowly and reach puberty later then other normal teens and people. Having sickle cell anemia can cause people to feel severe pain at times in their stomach, arms, legs, or other parts of their body. Periods of pain are referred to as pain crises. Depending on the person you never will know how severe the pains are, how long they last, or even how often they happen. Some people can have the crises happen more often than others. The crises can either be brief or last for hours, days, or even weeks. Sometimes the pain can be so intense to require hospital treatment. Sickle cell shaped blood cells block blood vessel. Blocking blood vessels can include the cause of leg ulcers, bone or joint damage, gallstones, kidney damage, painful long-lasting erections in males that is known as priapism, eye damage, and delayed growth. Also if they block blood vessels in the brain it puts people at risk of having a stroke. Signs of stroke include headache, seizures, weakness of the arms and legs, speech problems, a droop on one side of the face or body, and loss of consciousness. It is possible for some people to be ill enough to die from the disease, though that doesn’t happen to young people or

Sickle Cell Anemia is a horrifying, scary disease to have. Sickle cell anemia is a blood disease that is inherited. It comes from substitutions between a single amino acid and a component protein of hemoglobin. Globin, which is the component protein that has the substitution, isn’t effective. When someone has sickle cell, hemoglobin molecules with those component proteins, stick together and make strands of hemoglobin in red blood cells. Cells with that strand end up stiff and long, known as sickle shaped. Also, with sickle cell, those cells die faster than normal red blood cells and they aren’t easy to replace in a fast manner. Anemia within itself is when there is a huge shortage of red blood cells. When you think about the disease and

Sickle Cell Disease is a genetic disease caused by a SNP (Single Nucleotide Polymorphism). Which means it is caused by a single letter gene mutation. Through the advent of CRISPR/Cas9 the disease might be cured. It is a serious reality and will enter medical trials within a handful of years. Sickle Cell Disease is an inherited disease that predominantly affects people of African descent. Red Blood cells become rigid and sickle shaped, causing blockages and pain crises. In cases of Sickle Cell Disease the Beta-Globin are mutated causing faulty and deformed Hemoglobin proteins thus creating sickled and short-lived Red Blood Cells.

Sickle Cell Anaemia follows an autosomal recessive pattern of inheritance, meaning the gene is on an autosome as opposed to a sex chromosome, and the disease only expresses itself in individual who posses two copies of the gene. The prevalence of the disease can be mainly attributed to its pattern of inheritance, where a heterozygote advantage occurs. As the genetic disorder is incompletely recessive, a heterozygote individual will have a mixed phenotype. Normal function of red blood cells will occur, but there will also be

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. A person that is diagnosed with sickle cell anemia, their blood cells start to become clogged, causing blood clots, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.