Sickle-Cell Anemia

Sickle Cell Disease is an illness that affects people all across the globe. This paper will give a description of the sickness through the discussion of the causes, symptoms, and possible cures. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia.

Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape

Sickle Cell anemia is a group of inherited red blood cell disorders, or a collection of recessive genetic disorders characterized by a hemoglobin variant called Hb S. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long hard rods in the red cell when it gives

In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid "sickle" shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking to form a helical shape. Once this happens the cells cluster together and elongate and the cells start to "sickle". A person who has sickle cell anemia can only get it if both of their parents carry the sickle cell trait, if only one parent has the trait then there children are at risk for having the trait.

Sickle cell anemia (SCA) is an autosomal recessive genetic disorder. This missense mutation is characterized by mutant beta globin subunits that tend to stick together (Cummings, 2014). As a result, abnormally shaped red blood cells are produced by this disorder. The erythrocytes are sickle or crescent shaped. Sickling occurs under hypoxic conditions, in which there is insufficient supply of oxygen delivered throughout the body (Sun & Xia, 2013). In order to inherit this monogenic disease, one copy of the sickle globin gene from each parent must be passed on to the offspring (Ashley-Koch,

Sickle Cell Disease, commonly referred to as Sickle Cell Anemia, is a blood disease which red blood cells form an abnormal sickle or crescent shape. Red blood cells carry oxygen to the body and are normally shaped like a disc. This disease is genetically inherited from both parents. If you inherit the sickle cell gene from only one parent, you will have sickle cell trait. People with sickle cell trait do not have the symptoms of sickle cell anemia.

Sickle cell disease is a blood disorder in which red blood cells take on an abnormal shape. Sickle cell anemia is when the red blood cells hemolyze, or die. Sickle cell disease is inherited from generation to generation and is the most common in inherited blood disorders. An estimated 70,000-100,000 people in America are currently suffering from this disease, most of which are African Americans. One is diagnosed with sickle cell disease in early childhood generally around four months old when the signs and symptoms are presented. Because of its huge impact, the United States requires all newborns to be tested for this disease. [1] Sickle cell disease is known to affect, “approximately 1 in every 400-500 African American

While people are trying to find a breakthrough cure for diseases such as Cancer, Sickle Cell patients feel that they are left in the dark of the public’s eye. Each day thousands of people are being faced with the shocking truth of having to live a very hard, tiresome, and very painful life. According to researchers about one in four hundred African American is affected with Sickle Cell. Therefore it is felt that there should be a greater effort in trying to find a cure for this disease.

Sickle cell anemia is a severe condition in which there aren’t enough healthy, round red blood cells to carry adequate oxygen throughout your body. It is a form of anemia in which a mutated form of hemoglobin--a red protein responsible for transporting oxygen in the blood of vertebrates--distorts the red blood cells into a crescent shape. This causes low oxygen levels. Normal red blood cells are flexible and round allowing for easy movement throughout your blood vessels. In sickle cell anemia, the red blood cells are rigid and sticky and are shaped like a crescent moon--or a sickle. The effect is the red blood cells get caught in small vessels and block blood from reaching different parts of the body. This can cause pain and tissue damage.

All of the cells within the tissues of the body need a regular supply of oxygen to function. The hemoglobin found in red blood cells (RBC’s) are essential for the proper transport of oxygen molecules. They bind oxygen in the lungs and carry to every tissue within the body. Due to the structure of hemoglobin, normal RBC’s are donut shaped with a concaved center. This flexible shape is what allows the BRC’s to move freely into very small spaces such as capillaries where they will deliver their oxygen. Sickle cell anemia or other diseases that fall within the broader group of disorders characterized by SCD describe conditions where the protein (hemoglobin) has misfolded and altered the shape of the cell. Sickle hemoglobin allows for the formation of stiff rods within the red blood cell giving it a sickle, or crescent shape. This new shape is not flexible and can block or slow the flow of blood. When this occurs, oxygen cannot reach its intended tissues. This results in severe pain called crises, and these attacks occur

In fact, sickle cell trait is protective against malaria. Malaria is a disease caused by blood-borne parasites transmitted through mosquito bites. According to a theory, the genetic mutation is connected with the sickle cell trait that occurred thousands of years ago. The mutation increased carriers to survive malaria infection. Survivors then passed the mutation to their offspring. Sickle cell disease is known as a sickle cell anemia. Sickle cell diseases are caused by genetic change in hemoglobin. Hemoglobin is called sickle hemoglobin (Hb-S), has a tendency to develop into rod-like structures that alter the shape of the usually flexible and round red blood cells. The cells take on a shape that resembles that curved blade of a sickle. Sickle cells have a shorter life span than normally-shaped red blood cells. The results in chronic anemia caused by low levels of hemoglobin and decreased numbers of red blood cells. Sickle cells are flexible and stickier than normal red blood cells and can become trapped in small blood vessels preventing blood flow. The delivery of oxygen can result in pain and damage to connect tissues and organs. Sickle cell disease is within the

Sickle Cell Anemia is when a red blood cell is shaped into a different form and causes real bad diseases and sickness. Sickle cell Anemia also can be caused from blood loss. The sickle cells can get stuck in your blood cells and you won't be able to move your blood vessels. The molecule in the red blood delivers oxygen throughout the body. Other names for Sickle Cells is HbS, Hemoglobin S, Hemoglobin SS. Three important facts you need to know about sickle cell anemia is disorders, diagnosed, and genetic disorders.

Sickle cell disease is a chronic condition that a person can inherit from their parents in which it effects the globular structure of the patients red blood cells. A more sickle shaped structure, which can alter a person’s blood flow, replaces the more common globular structure. This impairment in blood flow can lead to blood clots, severe debilitating pain and damage to vital organs such as the liver, kidney and spleen. This disease currently affects over 90,000 people in the United States, with the majority of them being African American and

Sickle cell anemia is a disease you get from having two sickle hemoglobin within your red blood cells. There’s no other way to develop this disease than by genetics, which only occurs if both of your inherited cells are abnormal. Unfortunately, since sickle cell anemia is an inherited disease, there’s no way to prevent

“Sickle cell disease is an autosomal recessive disorder of blood cells caused by a genetic defect of the beta-globin chain of adult hemoglobin (HbA). The mutant forms of hemoglobin are sickle hemoglobin (HbS) because HbS polymerizes in deoxygenated blood, causing red blood cells to form a sickle shape. Normal hemoglobin has a biconcave disc shape that allows for maximum transportation of oxygen” (George, Mitchell, Mitchell, Eason, Fuh, & Embse, 2014).