Sickle Cell Anemia Research Paper

Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape

Sickle Cell Disease is an autosomal recessive genetic disease that occurs due to a mutation in the β-globin gene of hemoglobin. Autosomal meaning that it is not linked to a sex chromosome, so either parent can pass on the gene to their child. This mutation is a result of a single substitution of amino acids, Glutamic for Valine at position 6 of a β globin chain. The presence of this mutation causes

Sickle beta thalassemia is an inherited condition that affects hemoglobin, the protein in red blood cells that carries oxygen to different parts of the body. It is a type of sickle cell disease. Affected people have a different change (mutation) in each copy of their HBB gene: one that causes red blood cells to form a "sickle" or crescent shape and a second that is associated with beta thalassemia, a blood disorder that reduces the production of hemoglobin. Depending on the beta thalassemia mutation, people may have no normal hemoglobin (called sickle beta zero thalassemia) or a reduced amount of normal hemoglobin (called sickle beta plus thalassemia). The presence of sickle-shaped red blood cells, which often breakdown prematurely and can

Sickle-cell anemia is a genetic disease. People who are affected have two copes of the mutant gene. Normally, if a patient is heterozygous for the sickle-cell gene, they do not display any symptoms of the disease. Sickle-cell anemia is characterized by a deformation of red blood cells that are elongated and resemble sickles. In sickle-cell disease, mutated hemoglobin binds together to form large masses, which give the red blood cells their sickle shape. The hemoglobin found in this disease is referred to as hemoglobin S (Hb S), as opposed to normal adult hemoglobin, hemoglobin A (Hb A).

Sickle cell anemia is caused by a defect in the gene that controls the production of normal hemoglobin, which is an iron-containing protein in red blood cells that transports oxygen from the lungs to body tissues. The defective gene results in the production of abnormal hemoglobin known as hemoglobin S. If you have the disorder, you inherited one gene for hemoglobin S from each of your parents. The gene is recessive, so if you received a copy of the gene from just one parent, you are a carrier of the sickle cell gene.

Sickle cell anemia affects millions of people worldwide. Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. They don't last as long as normal, round red blood cells, which leads to anemia. Sickle cells contain abnormal hemoglobin that causes the cells to have a sickle shape. Sickle-shaped cells don’t move easily through your blood vessels. They’re stiff and sticky and tend to form clumps and get stuck in the blood vessels. The sickle cells also get stuck in blood vessels, blocking blood flow. This can cause pain and organ damage. Sickle cell disease is caused by a mutation in the

Millions of people are affected by this disease. Approximately 70,000 - 100,000 Americans have sickle cell disease while 2.5 million have the trait. Each year, in this country, about 1,000 children are born with sickle cell disease. The total number of babies born with sickle cell trait in 2010 was estimated to be greater than 60,000. Among people with SCD, the average age of death was about 43 years for females and 41 years for males. About 1 in 6 deaths occurred in those under 25 years of age and nearly half

What is Sickle Cell? The Sickle Cell Disease is a group of inherited red blood cell disorders. “People with the Sickle Cell Disease (SCD) have abnormal hemoglobin, called hemoglobin S or Sickle hemoglobin, in their red blood cells,” according to The National Heart, Lung, and Blood Institute. Hemoglobin is

Sickle Cell Anemia Disease is an inherited disease that turns healthy red blood cells (donut shape) into abnormal sickle shaped red cells which affects people's hemoglobin (a red protein responsible for transporting oxygen in the blood) (Naoum). This disease gets its name from the shape of red blood cells under low oxygen condensation which becomes sickle shaped. These sickle shaped cells get stuck in small blood vessels which causes people with this disease to have oxygen blockage (fudge foundation). People inherit this disease from their parents, if both parents have a trait of sickle cell anemia (people who inherit one sickle cell gene and one normal gene, they have a 25 percent chance of having an unaffected

Sickle Cell Anemia was the first diagnosed disease that was linked to the hemoglobin protein and genetically characterized. In 1910 Sickle cell disease was first characterized when Dr. B. Herrick wrote a report about a patient who suffered from a "strange disease" including such symptoms as asthmatic conditions and blood flow problems including body ulcers.

Sickle cell anemia (SCA), also known as HbSS disease, is a common life-threatening inherited blood disorder in the world. It is widespread in Africa, Italy, Greece, Turkey, India, and Saudi Arabia. Sickle cell disease was reported In Saudi Arabia for the first time in the 1960s. Although the rate of patients who suffer from sickle cell disease in Saudi Arabia is not clear, it varies according to the different provinces. The highest rate of patients is in the Eastern and southwestern provinces. This triggered the scientists to improve the Sickle cell anemia’s health care, determine the disease characteristics and amplifications, manage and control the symptoms, and limit the number of patients.

Sickle Cell Disease is an inherited blood disorder that affects the red blood cells. The red blood cells that turns normal red blood cells that are healthy and functioning into cells that are shaped sickled and crescent moon form become severely low and anemic. The oxygen - carry molecule in red blood cells that are called hemoglobin that creates an error in the red blood cell, that makes the cell sickled. When the sickled shaped cells block small vessels the condition results in oxygen depletion to the tissues surrounding the blocked vessels, Which the damages tissues causes many health

“Sickle cell disease is an autosomal recessive disorder of blood cells caused by a genetic defect of the beta-globin chain of adult hemoglobin (HbA). The mutant forms of hemoglobin are sickle hemoglobin (HbS) because HbS polymerizes in deoxygenated blood, causing red blood cells to form a sickle shape. Normal hemoglobin has a biconcave disc shape that allows for maximum transportation of oxygen” (George, Mitchell, Mitchell, Eason, Fuh, & Embse, 2014).

Sickle cell disease is the group of inherited disorder of the red blood cells that is characterize by abnormal hemoglobin. The red blood cells in sickle cell disease are rigid and sickle shape. Many complications arise due to the sickle shaped cells because these cells are not flexible as compare to normal red blood cells and and causes destruction and blockage of red blood flow. The most common form of sickle cell disease is autosomal recessive disorder is sickle cell anemia.

The target audience for this literature review is all who work within the health care facilities and have encounters with Sickle cell patients and as well as policy makers who can implement major changes. Sickle cell Disease is a life-threatening, severe, inherited chronic blood disorder. The healthy red blood cells which are round turn “sickle” shaped or moon-shaped which can cause the cells to break and die prematurely. The abnormal shape of the cells ends up blocking blood vessels which prevents oxygen from circulating around the body resulting in severe, intense pain in the chest, back, limbs, and joints. Aside from the actual physical pain that Sickle Cell patients go though on a regular, there are other things that they have to deal with