Sickle Cell Disease And Its Effects

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle Cell Anemia affects many people all over the world; Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. When a person is diagnosed with sickle cell anemia the blood cells start to become clogged blood vessels, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.

Sickle Cell Disease is an illness that affects people all across the globe. This paper will give a description of the sickness through the discussion of the causes, symptoms, and possible cures. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia.

Sickle Cell Disease is an autosomal recessive genetic disease that occurs due to a mutation in the β-globin gene of hemoglobin. Autosomal meaning that it is not linked to a sex chromosome, so either parent can pass on the gene to their child. This mutation is a result of a single substitution of amino acids, Glutamic for Valine at position 6 of a β globin chain. The presence of this mutation causes

The term sickle cell infection (SCD) depicts a gathering of acquired red platelet issue." Normal red blood cells are shaped like discs or donuts. They are soft and flexible so they can easily move through very small blood vessels"(anonymous, 2015).Individuals with SCD have anomalous hemoglobin, called hemoglobin S or sickle hemoglobin, in their red platelets. Hemoglobin is a protein in red platelets that conveys oxygen all through the body. The most well-known sort is known as, sickle-cell frailty (SCA) and there is A few Types of Sickle Cell Sickness: Hemoglobin SS, Hemoglobin SC, Hemoglobin SD. In the Unified States, a great many people with sickle cell illness (SCD) are of African family line or recognize themselves as dark. About1 out of 13 African American children is

Sickle-Cell Anemia is an inherited, chronic blood disease in which the body produces abnormally shaped red blood cells. When the blood cells become crescent/sickle shaped, they are unable to deliver adequate amounts of oxygen to other cells. Also, these unusual “sickle” cells block blood pathways to the limbs and organs, limiting the amount of blood flowing throughout the body. It causes pain, organ damage, and anemia (low blood count). Unfortunately, however, when sufferers are born with this disease, they live life knowing it is incurable.

Sickle Cell Anemia or Sickle Cell Disease (SCD) is a passed down blood disorder that attacks and destroys the red blood cells. This Disease was first discovered back in 1910. The disease was first described as a clinical entity by Herrick1 in 1910 (Anderson & Ware 1932). Sickle cell sickness is brought about by a change in the hemoglobin-Beta quality found on chromosome 11. Hemoglobin transports oxygen from the lungs to different parts of the body. Red platelets with typical (hemoglobin-An) are smooth and round and coast through veins. Typical red platelets are round like doughnuts, and they travel through little blood tubes in the body to convey oxygen. Sickle red platelets turn out to be hard, sticky and molded like sickles used to cut wheat. At times these blood cells can become crescent shaped and have a hard time passing through small blood vessels, this keeps red blood cells and the oxygen they carry from getting to all parts of the body. This causes less blood to reach the body at this point the tissues that have not received a normal blood flow will become damaged. Individuals who have sickle cell

Sickle cell disease is categorized as an autosomal recessive disease. That means in order for one to inherit the disease, they must inherit two recessive alleles for sickle cell disease, or hemoglobin S gene. Having only one recessive allele makes you a carrier. The disorder causes the affected person’s red blood cells to disfigure into a crescent or sickle, which differs from the normal red blood cells that shaped into a doughnut. Sometimes, cells in a sickle shape cannot get through the narrow passageways of the blood vessels as easily as normal red blood cells. This blocks blood from entering and oxygen can’t reach the affected person’s organs. It can also crystallize and block arteries and

Sickle cell anemia is an inherited disease causing red blood cells to malfunction. It is a disorder the affects hemoglobin the protein found in red blood cells. People with this disease genetically inherit this untypical hemoglobin. This means that it cannot be transmitted from one person to another like the flu virus. These people have what its called hemoglobin (s). What this does is that instead of the red blood cell being circle-shaped it would appear to be a half moon shaped cell. It is necessary for the cells to be round so that they would be able to pass though small and large blood vessels.

Sickle cell disease is an inherited blood disorders which leads to an abnormal hemoglobin or red blood cell shape. Hemoglobin is the protein found in red blood cells which transports oxygen throughout the body. Sickle cell disease is inherited by being passed on through genes from parents to their offspring. It is not a contagious as one cannot contract it through an infection or being with someone else. Individuals with Sickle cell disease inherit two abnormal hemoglobin genes from each parent respectively. The alteration in the composure of hemoglobin of someone with sickle cell leads to the change in red blood cell shape from a normal circle to a sickle shape. This leads to blood clotting, dehydration, anemia, and low oxygen in tissues. Furthermore, some other negative side effects of Sickle cell anemia are weakened bones and an overworked heart. Although Sickle cell has no present-day cure, there are experimental trials being conducted through bone marrow transplant and has proven effective. The primary goal of this transplant study is to reduce and ultimately eliminate the frequency of the Sickle cell episodes, crisis maintain normal hemoglobin levels. There are ways to prevent episodic sickle cell crisis such as staying adequately hydrated, limiting physical activities, blood transfusions and taking

Sickle cell disease is a chronic condition that a person can inherit from their parents in which it effects the globular structure of the patients red blood cells. A more sickle shaped structure, which can alter a person’s blood flow, replaces the more common globular structure. This impairment in blood flow can lead to blood clots, severe debilitating pain and damage to vital organs such as the liver, kidney and spleen. This disease currently affects over 90,000 people in the United States, with the majority of them being African American and

Sickle cell disease is a hereditary blood disorder most common in the African American community. Many people are carriers of the sickle cell trait, however in order for a person to develop sickle cell disease both parents must have passed on the trait to their child. Sickle cell disease causes a mutation in normal red blood cells resulting in decreased tissue perfusion and organ damage. This causes partial or complete replacement of normal hemoglobin with abnormal shaped sickled cells. An abnormal shaped sickled cell may become lodged to a blood vessel where other cells then bind to it and begin to form a clump. The blood vessels continually attach to each other and result in a blockage of small blood vessels eventually resulting in organ

Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels, but the ones infected with sickle cell tend to be more of a crescent shape and don't slide as easy. To get the disease you must receive two of the genes from your parents. If you only have one you will have what is called Sickle Cell trait but there are no symptoms or problems for most people.

Sickle cell disease (SCD) is an autosomal-recessive inheritance that results from a alteration in the gene responsible for the hemoglobin production. A healthy hemoglobin A is produced under normal circumstances, but for people with SCD they produce a sickle hemoglobin S. (Gill, V., 2010) Unlike normal hemoglobin A, hemoglobin S has a tendency to agglutinate, or clump together, when the oxygen supply is decreased. As a result, the red blood cells take on a rigid or “sickle” shape causing the diameter of the cells to increase relative to the size of normal red blood cells. These sickled cells block the blood vessels causing compromised blood supply to the tissues and bones, resulting in a vaso-occlusive crisis. (Jisieike,

Sickle Cell Anaemia is the commonest of most severe form of Sickle Cell Disease. SCD is a collective term for hereditary haemoglobinopathies caused by the inheritance of a mutated haemoglobin allele (sickle haemoglobin-HbS) in the erythrocytes. The HbS mutation is caused by a Valine to Glutamic acid substitution at the 6th amino acid of the β-globin chain. (Harmon et al., 2012)The first known case of SCD in the western world was recorded in 1910 in the United States, when a 20 year old black student from Grenada presented abnormal erythrocytes upon examination of his blood. This can now be recognised as the major characteristic of SCD where the erythrocytes assume the shape of a sickle when deprived of oxygen in vivo hence the name of the disease. Although SCD is most prevalent in individuals of African ancestry, the disease is also existent in people from Meditterenean Europe,Hispanic, Midle Eastern and Indian Asian backgrounds. The explanation of the regional specificity of SCD is the correlation between the geographical locations where Falciparum Malaria was once endemic and high incidents of Haemoglobin S mutations in those particular regions. However, the occurrence of SCD disease in regions that have no known history of Falcipurum Malaria can be attributed to migration. In Britain for example, the first incidents of SCD were recorded after the postwar immigration of the non-white population

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. A person that is diagnosed with sickle cell anemia, their blood cells start to become clogged, causing blood clots, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.