Sickle Cell Disease Epidemiology Case Study

In order to get Sickle Cell Anemia, you must have the Sickle Cell Trait. This is defined as "A person who carries one sickle hemoglobin producing gene inherited from their parents and one normal hemoglobin gene." (3) People who only have one copy of the mutation have the trait. "It is estimated that 1 in 12 African Americans has sickle cell trait." (3) Having the trait will NOT cause SCD. However, having the gene does allow you to pass the mutation on to your children. In fact, "A child conceived by two people with sickle cell trait has one chance in two of also having sickle cell trait, one chance in four of having sickle cell anemia."(3)

Because people with sickle cell trait don't have the disease, they may never discover that they carry the gene. That's why it's recommended that teens who are unsure of their sickle cell status ask their doctors about testing. The National Institutes of Health recommends that all newborns be screened for sickle cell disease, and testing at birth is now required in almost every state. This helps infants with sickle cell anemia get the care and treatment they need right away.

Sickle cell disease is a disease that is most prevalent in people of African descent along with people of Mediterranean and Middle Eastern origin. This disease is known to affect about 70, 000 Americans and about 2 million people carry the trait (meaning that, they carry a single gene mutation).

Most individuals in the United States with sickle cell disease (SCD) identify as being of African ancestry, or black (National Heart Lung and Blood Institute, 2017). Latinos are known to be associated with having type O blood; in fact, 57% of Latinos have type O blood, 54% being O+ and 3% being O- (Fox, 2012). Although type O is the most common blood type overall, it is important to note that more than half of Latinos, 57%, makes them the largest ethnic group to be associated with being type O. If there is a disease associated with African Americans and a blood type frequency that correlates with Latinos, there could be a disease or multiple diseases associated with Latinos. In fact, a statistics and fact sheet from the American Heart

Sickle cell crisis is an acute form of sickle cell disease where pain and sickling are extensive (Byar, 2013). SCD is a genetic disease that predominantly affects black people of African decent (Gersten, 2016). Abnormal hemoglobin chains are the main issue with SCD (Byar, 2013). Normal hemoglobin chains are comprised of 99% hemoglobin A (HbA) however, in SCD an abnormal form of the gene, hemoglobin S (HbS) is present in approximately 40% of total hemoglobin (Byar, 2013). In order for a person to be born with SCD, both parents must carry the abnormal gene, HbS (Byar, 2013). HbS is extremely sensitive to the changes in oxygen amount of the RBC and when exposed to decreased oxygen the HbS cause the RBC to distort and become sickle-shaped,

It has always been assumed that genetics and lifestyle play a major role in the presence of health disparities and health care issue that affects African-Americans. This paper provides a historical background to a key disease more prevalent in the African American community, Sickle Cell Anemia, the history behind the disease, genetic mechanisms that influences once probability of inheritance and in-depth treatment on how to manage, prevent and sustain a healthy lifestyle when dealing with sickle cell anemia. Sickle cell anemia is a hereditary disease that alters important aspects of the body physiologically and can be inherited via genes. Sickle cell disease (SCD) was first identified in 1910 and has existed in the continent of Africa for five

Sickle cell disease (SCD) occurs in 1 out of every 365 African American births compared to 1 out of 16,000 Hispanic-American births (1). SCD is a group of red blood cell disorders in which patients have a sickle or moon-shaped red blood cell due to an abnormal S hemoglobin. While sickle cell disease is relatively rare in American births, this is an alarming statistic among people of Sub-Saharan (west and central) African descent. An interesting fact is that SCD occurs more often among people from parts of the world where malaria is or was common, such as Sub-Saharan Africa (1). In addition, it is believed that people who carry the sickle cell trait are less likely to have

Approximately 100,000 people suffer from Sickle Cell Anemia everyday and about 2 million people have the Sickle Cell trait in the United States alone. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Pruthi 2018). The disease is estimated to occur in 1 in 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans (Pruthi 2018). Sickle cell anemia is an inherited form of anemia, a condition in which there aren't enough healthy red blood cells to carry adequate oxygen throughout your body normally, your red blood cells are flexible and round, moving easily through your blood vessels. In sickle cell anemia, the red blood cells become

Sickle cell disease affects millions of people worldwide. It is most common among people whose ancestors come from Africa; Mediterranean countries such as Greece, Turkey, and Italy; the Arabian Peninsula; India; and Spanish-speaking regions in South America, Central America, and parts of the Caribbean. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans. The disease is estimated to occur in 1 in 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans.

Sickle cell anemia affects a wide range of demographics, from young to old. However, there are specific groups of people who are likely more prone to this disease than any other group. This disease affects millions of people worldwide regardless of age, but it is particularly common amongst those who derive from specific regions of the world. Sickle cell anemia is most common in those whose ancestors are derived from the sub-Saharan region of Africa. Furthermore, other regions that are known to have a high number of people containing sickle cell anemia are from Mediterranean countries, the Arabian Peninsula, and Spanish-speaking regions as well ("Who Is at Risk for Sickle Cell Anemia?"). This disease originated from the sub-Saharan region of Africa, and later migrated to other areas through the spreading of other diseases such as malaria. This is due to the fact that sickle cell disease occurs habitually in areas that are prone to diseases such as malaria. Although this disease can affect anyone, the highest cases of sickle cell anemia were found in African-Americans than in any other race. In the United States, sickle cell disease affects about 70,000 to 100,000 Americans ("Who Is at Risk for Sickle Cell Anemia?"). The statistics show that 1 out of every 500 births is affected by sickle cell disease for African-Americans. For the Hispanics, 1 out of every 36,000 births is prone to sickle cell disease ("Who Is at Risk for Sickle Cell Anemia?"). The age ranges for which a

Sickle cell anemia is more common in sub-Saharan regions of Africa, where malaria is prevalent, than it is in regions where malaria is not common. This is because being heterozygous for sickle cell anemia in malaria-prone regions carries a fitness.

In the U.S., SCA occurs most often among African-Americans, approximately 10% of whom are carriers of the sickle cell gene. This prevalence results in SCA in approximately 0.2% of live births in the African-American population, or about 1 in 500. In parts of Africa, over 30%

Thousands of years ago, a genetic mutation occurred in people from the Mediterranean basin, India, Africa, and the Middle East. As the Malaria Epidemic attacked people of these countries, carriers of the defective hemoglobin gene survived. Carrying one defective gene means that a person has a sickle cell trait. Two parents with the trait will produce a child with sickle cell anemia. People of these countries migrated and spread to other areas. In the Western Hemisphere, where malaria is not much of a problem, having the abnormal hemoglobin gene has lost its advantage. Any child born from parents that each has the trait will be born with the disease.

This disease is a genetic disease and it is hereditary. It is inherited as an autosomal recessive disease. This means that in order to get the gene you must receive a recessive trait from your mother and your father. The parents could both be heterozygous for the trait and therefore not have the disease, but instead they would both be a carrier. There are only a few ways that the parents could possibly pass the trait. One possibility of having a child with sickle-cell disease is if both parents are heterozygous and they both pass on their recessive allele, (25% chance for offspring to have sickle-cell disease). Another possibility

Sickle cell anemia is an anemia that is inherited and mostly affects people whose heritage can be traced back to places where malaria was prevalent. There are approximately 100,000 Americans that have the disease and many more with the trait. Several of my family members are afflicted by this medical condition that causes red blood cells to take on an irregular shape.