Sickle Cell Disease In Children Research Paper

In order to get Sickle Cell Anemia, you must have the Sickle Cell Trait. This is defined as "A person who carries one sickle hemoglobin producing gene inherited from their parents and one normal hemoglobin gene." (3) People who only have one copy of the mutation have the trait. "It is estimated that 1 in 12 African Americans has sickle cell trait." (3) Having the trait will NOT cause SCD. However, having the gene does allow you to pass the mutation on to your children. In fact, "A child conceived by two people with sickle cell trait has one chance in two of also having sickle cell trait, one chance in four of having sickle cell anemia."(3)

Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).

Sickle cell disease is a disease that is most prevalent in people of African descent along with people of Mediterranean and Middle Eastern origin. This disease is known to affect about 70, 000 Americans and about 2 million people carry the trait (meaning that, they carry a single gene mutation).

Health care disparity with sickle cell Disease Patient’s    Thesis Statement.   Barriers to racial health care equity include the health care system (insurance, funding), the patient (poor health literacy, fear, mistrust), the community (awareness, advocacy), and the providers (bias, attitudes, expectations, stereotyping).      Sickle cell disease (SCD) is the most prevalent genetic hematological disorder worldwide predominantly affecting populations of West African and African Caribbean descent, as well as populations of Asian, Middle Eastern, and Mediterranean origins (Burne, 2008). It affects about 80,000 people in the United States and is the most common inherited blood disorder (O’Cconnor, 2014). It affects 1 in every 500 births of African

Sickle cell crisis is an acute form of sickle cell disease where pain and sickling are extensive (Byar, 2013). SCD is a genetic disease that predominantly affects black people of African decent (Gersten, 2016). Abnormal hemoglobin chains are the main issue with SCD (Byar, 2013). Normal hemoglobin chains are comprised of 99% hemoglobin A (HbA) however, in SCD an abnormal form of the gene, hemoglobin S (HbS) is present in approximately 40% of total hemoglobin (Byar, 2013). In order for a person to be born with SCD, both parents must carry the abnormal gene, HbS (Byar, 2013). HbS is extremely sensitive to the changes in oxygen amount of the RBC and when exposed to decreased oxygen the HbS cause the RBC to distort and become sickle-shaped,

It has always been assumed that genetics and lifestyle play a major role in the presence of health disparities and health care issue that affects African-Americans. This paper provides a historical background to a key disease more prevalent in the African American community, Sickle Cell Anemia, the history behind the disease, genetic mechanisms that influences once probability of inheritance and in-depth treatment on how to manage, prevent and sustain a healthy lifestyle when dealing with sickle cell anemia. Sickle cell anemia is a hereditary disease that alters important aspects of the body physiologically and can be inherited via genes. Sickle cell disease (SCD) was first identified in 1910 and has existed in the continent of Africa for five

In conclusion, sickle cell anemia and the sickle cell trait are more common in African-Americans and people who live in places where malaria is common. Individuals with the trait seem to live normal and healthy lives, however individuals who have the trait and experience high altitudes or vigorous exercise tend to feel unwell because of the lack of oxygen getting into the cells causing them to sickle. In addition, the sickling of the cells can be reversible to a certain extent in people with the trait, however people who have sickle cell anemia the sickling of the cells is irreversible due to the severity of the disease.

Sickle cell disease (SCD) occurs in 1 out of every 365 African American births compared to 1 out of 16,000 Hispanic-American births (1). SCD is a group of red blood cell disorders in which patients have a sickle or moon-shaped red blood cell due to an abnormal S hemoglobin. While sickle cell disease is relatively rare in American births, this is an alarming statistic among people of Sub-Saharan (west and central) African descent. An interesting fact is that SCD occurs more often among people from parts of the world where malaria is or was common, such as Sub-Saharan Africa (1). In addition, it is believed that people who carry the sickle cell trait are less likely to have

According to Centers for Disease Control and Prevention “Sickle cell Trait is people who inherit one sickle cell gene and one normal gene have sickle cell trait (SCT). People with SCT usually do not have any of the symptoms of sickle cell disease (SCD), but they can pass the trait on to their children.” (sickle cell trait)

Sickle cell disease is a chronic condition that a person can inherit from their parents in which it effects the globular structure of the patients red blood cells. A more sickle shaped structure, which can alter a person’s blood flow, replaces the more common globular structure. This impairment in blood flow can lead to blood clots, severe debilitating pain and damage to vital organs such as the liver, kidney and spleen. This disease currently affects over 90,000 people in the United States, with the majority of them being African American and

Sickle Cell is a disease that you hear about, but not as often as you should. It is an inherited disease, “the name derives from the red cells in the blood of sufferers and they take on the shape on a sickle (crescent shape).” Another name for sickle cell is sickle cell anemia, because in some cases people become anemic. With this disease comes low levels of hemoglobin, which is the red substance in your blood that contains iron and carries oxygen. Due to the irregular shaped cells this can cause blockage and prevent normal blood flow, this prevents the cells carrying oxygen around the body properly. Shortage of oxygen can lead to damage that can occur in almost just about any organ in the body. Sickle cell is found more often in African Americans. It is said that the disease originated from Africa and most common in West Africa.

In this article, researchers at CWRU in Cleveland Ohio created a microfluidic platform to monitor the extent of someone's sickle cell disease. This could be instrumental in tracking the progress of sickle cell disease and could be responsible for recognizing problems and finding solutions. Due to the short length of the article, it didn’t go into anything about how microfluidics worked. On another site, I found it requires about a microliter of blood. Most chips have seven channels that each hold reagents and markers that identify targeted molecules. A syringe acts as a vacuum and pulls the blood through the channels. Then gold and silver nanoparticles attach to molecules and provide color which allows you to interpret the tests. It takes under

Thousands of years ago, a genetic mutation occurred in people from the Mediterranean basin, India, Africa, and the Middle East. As the Malaria Epidemic attacked people of these countries, carriers of the defective hemoglobin gene survived. Carrying one defective gene means that a person has a sickle cell trait. Two parents with the trait will produce a child with sickle cell anemia. People of these countries migrated and spread to other areas. In the Western Hemisphere, where malaria is not much of a problem, having the abnormal hemoglobin gene has lost its advantage. Any child born from parents that each has the trait will be born with the disease.

This disease is a genetic disease and it is hereditary. It is inherited as an autosomal recessive disease. This means that in order to get the gene you must receive a recessive trait from your mother and your father. The parents could both be heterozygous for the trait and therefore not have the disease, but instead they would both be a carrier. There are only a few ways that the parents could possibly pass the trait. One possibility of having a child with sickle-cell disease is if both parents are heterozygous and they both pass on their recessive allele, (25% chance for offspring to have sickle-cell disease). Another possibility

The genetic disease sickle cell anemia is a very fascinating disease. I was glad and beyond astonished on how this genetic disease was discovered, described, treated, and all the obstacles the carrier had to weave through each and every day. Sickle cell anemia is actually carried on the 11th chromosome. Chromosome 11 codes for the beta subunit of the hemoglobin protein. As a result, since the chromosome is damaged it cannot produce hemoglobin for the cell causing the cell to form into a “C” or sickle shape, hence the name sickle cell anemia. Sickle cell can cause hand-foot syndrome which is swelling of your hands or feet, very common in infected newborns. You can also experience episodes of pain. It is the most common symptom to deal with.