Sildenafil Research Paper

Many doctors, pharmacists, biochemists and scientific researchers have engaged tremendous efforts to providing drugs and supplements that would help overcome sexual malfunction and ill-health.

Sildenafil, a phosphodiesterase type 5 inhibitor, is used to treat patients with pulmonary hypertension. The objective of the study was to evaluate the efficacy and tolerability of 3 different doses of sildenafil. The clinical importance of this study was to determine which dose of sildenafil was most effective in patients with pulmonary hypertension.

Sildenafil citrate is one of the drugs of choice for the treatment of erectile dysfunction. It is a selective inhibitor of cGMP-PDE5 or the cyclic guanosine monophosphate-specific phosphodiesterase type 5. Since erectile dysfunction or impotence is estimated to affect more than 140 million men around the world, many tend to resort to medications such as this drug. More than half of these affected men have physical or medical issues that lead to their impotence such as diabetes, and urological, neurological and circulatory conditions.

Similar to sildenafil, tadalafil may be prescribed for treatment of erectile dysfunction (ED). Tadalafil is marketed as Cialis for ED, and as Adcirca for PAH. Adcirca is prescribed as a 40mg dose (taken as two, 20mg tablets) by mouth, every day in the treatment of PAH. Patient compliance may be better with tadalafil compared to sildenafil since oral dosing frequency is 1x daily vs. 3x daily respectively due to Tadalafil’s longer half-life. As a PDE-5 inhibitor, Adcirca has similar ocular side effects to sildenafil including cyanopsia, chromatopsia, and blurred vision. Non-AION has also been reported in some patients taking Adcirca, though these patients had predisposing risk factors including a smaller disc, age > 50 years old, diabetes, hypertension, and smoking. However, a direct link between PDE-5 inhibitor use and Non-AION has not been found. Patients meeting this patient profile should be informed of their increased risk of developing NAION if using a PDE-5 inhibitor (“Adcirca (Tadalafil)-Uses, Dosage, Side

History: Viagra also known as sildenafil citrate was originally synthesized at Pfizer headquarters in Sandwich, Kent, England by a group of pharmaceutical chemists in 1989. The two people who are attributed with creating sildenafil citrate, and who were consequently the most important in doing research and development on the drug were chemists Peter Dunn and Albert Wood. They originally composed this drug, sildenafil citrate, to help treat angina and high blood pressure, two symptoms that are usually indicative of coronary heart disease. The drug is classified as UK-92480. Later, in 1991, when the drug is patented by Dr. Nicholas Terrett, who is also referred to as “the father of Viagra”, sildenafil citrate received its modern name, Viagra. A few years afterward, in the early 1990s, Pfizer compiles several early test in order to prove Viagra’s capabilities in reducing angina and treating high blood pressure. These trials, however, prove that Viagra is not effective at treating this symptoms at all, although the trial patients were reporting ongoing erections after consuming Viagra. This got Pfizer thinking, and in March of 1998, Pfizer re-patents Viagra and the FDA approves it, and instead markets it as a drug to help people who are suffering from erectile dysfunction (ED), and this time Pfizer has research to back their claim. In the first year alone, over 40,000 prescriptions were written

Erectile dysfunction also known as impotence is a condition that a number of men face but few can dare talk about, maybe it's because it seems to be quite embarrassing. The truth is this condition can actually be fixed or at least managed and one does not necessarily require pills or pumps. There is simply a diet plan that one can take, found in the book Coming Back To Manhood and it helps cure this condition. There are two testimonials that I came across, about people who have used the diet plan in this book, that made me realise that erectile dysfunction is not something that should make a man feel like it’s the end of their life.

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Sildenafil is the first drug that was found to provide relief from the symptoms of erectile dysfunction or simply male impotency. It is delivered to the body as its citrate salt and is available in many forms. The drug has the ability to boost libido and provide long erections to people who especially suffer from maintaining an erection for the required period.

Erectile Dysfunction, according to the American Sexual Health Association, is the inability to maintain an erection that is suitable for intercourse. It is a condition that can affect men of any age. Even though erectile dysfunction can affect men of all ages, it is most prevalent in the elderly population. Erectile dysfunction can be due to many issues such as psychological problems, heart disease, high blood pressure, Diabetes, Parkinson’s disease, trauma from surgery related to prostate cancer and even hormonal problems. Erectile dysfunction does not only involve men, it also involves their partner as well, and can cause the male to withdrawal from any sexual activity due to embarrassment . In regards to erectile dysfunction this paper

Erectile dysfunction is growing at a rapid pace in young men around the globe. This is because of the sedentary lifestyle they are living and this is affecting their health severely. When a person is affected by any kind of disease, it reflects in his health. Erectile dysfunction or impotence is a problem when men are unable to maintain their erection for sexual activity. In case you face this problem occasionally, then it is not a problem for concern, but if you are regularly facing it, then it is an issue. You need to deal with it at the earliest possible otherwise it may bring in several problems. This will lead to depression, relationship issues and performance anxiety during lovemaking. This will further damage your health affecting you psychologically.

You have got to trust the method to guard you and to find you the satisfactory remedy. Most commonly, this will likely without difficulty be a prescription for Viagra, Cialis or Levitra. Hello, wait a minute. That suggests going to a pharmacy. In case you find that shuttle to the pharmacy a bridge too far, there may be perpetually a web based pharmacy where that you would be able to purchase on-line. In some matters, there can be the looks of larger privacy. However who're these persons within the on-line pharmacy? And will the supply man now not suspect what is in the plain package

The one drawback to Viagra was once that nobody knew for sure when precisely he has to take it. The technique to this main issue is that the manufacturer new alleviation for ED, in the type of a capsule referred to as Cialis appeared in the marketplace. This new magic capsule induced a plus of simple task to men all over the arena, being a extra evolved viagra. The effect of this tablet is that, as soon as taken, lasts as much as 36 hours. On this method, men shouldn` t time table exactly anymore the sexual encounters with their

Men due to straining lifestyle develop weaknesses and debilities at an early age which can raise problems related to erections, herbal remedies for treatment of erectile dysfunction at 30 are safe and very effective methods to get rid of the problem. Males who do not take proper care of their diet and timings, lead a stressful lifestyle and are in habit of alcohol intake or too much smoking weaken their reproductive system. Males who take medicines like tranquilizers; sedatives etc for a longer duration can also develop problems which hinder erections.

Firstly, age is a valuable dimension due to the strong positive correlation to erectile dysfunction (ED) incidence. Secondly, as shown in the demographic data presented by Lilly ICOS, most men who suffer from ED are either married or living together with their partner. Being the influence of the spouse one of the

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