Six Leading Cause Of Alzheimer's Disease

Alzheimer 's disease (AD) was discovered by a German doctor Alois Alzheimer in 1906 when he found amyloid plaques and neurofibrillary tangles in the autopsy of a woman who died of an unknown mental disease. The extracellular amyloid plaque deposits, composed of insoluble amyloid-Beta peptide were hypothesized to be the main etiological factor. “The most important abnormality is an excess of Amyloid-beta peptides brought about through either overproduction or failure in degradation.” (Uzun, Kozumplik, & Folnegović-Smalc, 2011) Later, it was discovered that intracellular neurofibrillary tangles composed of hyper-phosphorylated, helically-paired tau

Alzheimer’s disease is the 6th leading cause of death in America. It kills more than breast cancer and prostate cancer combined. Alzheimer’s accounts for 70-80% of dementia cases. By the age of 65, 1 in 9 people are diagnosed and by the age of 85, 1 in 3 people will have the disease. According to the Alzheimer Association, 5 million people in American have Alzheimer’s. Alzheimer’s starts to form 20 years prior to being diagnosed. Learning about Alzheimer’s can help families understand how Alzheimer’s is more than just memory loss, it is an incurable mental disease.

The disease called Alzheimer’s is the fourth leading cause of death in the United States (Weiner, 1987). It is estimated that the elderly population will double between now and 2030. During this period, the number of elderly will grow by an average of 2.8% annually (U.S. Census Bureau, 2001). By 2050, the number of people with Alzheimer’s is estimated to range from 11.3 million to 16 million (Alzheimer’s Association, 2005). These startling numbers should prompt an examination into one of the leading causes of death among this group of people. Understanding what Alzheimer’s is and the known causes of the disease are a good starting point. For those who have aging family members, knowing the risk factors and warning

“Alzheimer’s disease is the most common type of dementia in elderly people which accounts for 60 to 80 percent of cases (Krishnan, D. S.)”. World Health Organization indicated that Alzheimer’s disease is the “6th leading cause of death in the

Alzheimer’s disease (AD) is a progressive and fatal form of dementia, frequently seen in the elderly altering their cognition, thought process and behavior. AD is reported in about half of patients that have a dementia diagnosis; one study states that about 10.3% of the population over 65 years is affected by dementia with an increase to almost 50% over the age of 8 (Beattie, 2002). Alzheimer’s disease is not a normal part of the aging process in humans, but rather found in a group of diseases that affect the brain leading to a decline in mental and physical control. AD when diagnosed has a very slow and gradual course, initially affecting the individual’s short term memory (Beattie, 2002). Alzheimer’s disease is the 6th leading cause of death, affecting more than five million people in the United States and is also one of the most common forms of dementia. Dementia can be defined as a disorder of progressive cognitive impairment severe enough to affect daily functions of an individual’s life (Fillit, et al., 2002).

Of the estimated 5.5 million Americans living with this disease, an estimated 5.3 million are age 65 and older. Approximately 200,000 individuals are under age 65 and have younger-onset Alzheimer’s diease. One in ten people age 65 and older has Alzheimer’s disease. Alzheimer’s disease is the sixth leading cause of death in the United States. Every 66 seconds someone in the United States develops the disease. It kills more people than breast cancer and prostate cancer combined. Deaths from Alzheimer’s increased 68% between 200 and 2010. This disease is affecting more and more people each day and becoming a real problem in the United States. Unless Alzheimer’s can be effectively treated or prevented, the number of people with it will increase significantly if current population trends

Auguste Deter was the first patient who had such a serious case of dementia that Alois Alzheimer decided to look at her brain when she died. Deter was 51 years old when she began to show signs of what is now considered Alzheimer’s Disease or AD. When she died, Alois Alzheimer, a German physician, decided to look into her brain. He wished to see what was causing her to act so wild and uncontrollable. According to the Alzheimer’s Association, he found that parts of her brain and the cells seemed to be dead. The disease soon was named after Alzheimer because of his discovery and has grown to be recognized throughout the world. While there are other diseases in need of research, Alzheimer's is a growing disease that is in need of more research

Early-onset Alzheimer’s is a rare, but fast stage of Alzheimer’s disease. According to Glenn E. Smith, Ph.D., a neuropsychologist at Mayo Clinic, in Rochester, Minn. (2014), Early-onset Alzheimer’s is an uncommon form of dementia that strikes about 5 percent of patients with symptoms before the age of 65. This form of Alzheimer’s has been known to develop between the ages 30 and 40, but that’s very uncommon (Smith 2014). Scientists do not have an explanation of why people get the disease younger than others. Early-onset Alzheimer’s that is hereditary in family members is connected to three different genes that differ from the APOE gene that can increase your risk of Alzheimer’s in general (Smith 2014). The innate conduit of inheritance is much stronger in early-onset Alzheimer’s (Smith 2014). If one has a genetic mutation

Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior. It is the most common form of Dementia which is a general term for a decline in mental ability severe enough to interfere with daily life. Alzheimer’s accounts for 60-80% of dementia cases. Based on 2018 Alzheimer’s Association statistics, there are more than 5 million Americans living with Alzheimer’s over the age of 65 (Alzheimer’s Association, 2018). Many scientists state the death rate for heart disease has declined by 11% while death by Alzheimer’s has raised by 123% (Alzheimer’s Association, 2018). It is considered to be the 6th leading cause of death in the United States (Alzheimer’s Association, 2018). Alzheimer’s disease(AD) is an abnormal aging

Alzheimer’s disease is the six leading cause of death in America with its major cause still unknown. Scientist understand that even before early onset symptoms appear there are communication errors between the neurons of the brain. As the disease progresses, family members often notice that their loved ones are more forgetful then normal. The disease progressively worsens until one is unable to recognized loved ones, has difficulty speaking, walking, and even swallowing. The brain of one with advanced Alzheimer’s is actually radically different from that have a healthy brain.

Alzheimer’s Disease (AD) is characterized by gradual cognitive decline that beings with the inability to create recent memories or thoughts, which then proceeds to effect on all intellectual functions (Mayeux & Stern, 2012). AD affects an estimated 5.5 million people in the United States, and 24 million people worldwide (Mayeux & Stern, 2012). The incidence of Alzheimer’s disease is rising in line with the aging population, therefore; AD is most common in older patients around the ages of 60-85 (Mayeux & Stern, 2012). Alzheimer’s Disease is the sixth most common cause of death ("Latest Alzheimer 's Facts and Figures", 2015). Therefore, in the United States, one individual will develop the disease in every 67 seconds ("Latest Alzheimer 's Facts and Figures", 2015).

Alzheimer’s disease is a type of dementia that causes problems with memory, thinking and behavior. It is also a progressive disease with no cure. Alzheimer’s disease was first discovered by Dr. Alois Alzheimer in 1906. He noticed changes in brain tissue of a woman who died of an unusual mental illness. Although there are many types of dementias, Alzheimer's is the most common. It accounts for 60-80% of dementia causes. Aging is a normal process but Alzheimer’s is not a normal part of the aging process. Early onset Alzheimer’s affects 5% of patients diagnosed with Alzheimer’s and it appears between the ages of 40’s and 50’s. Alzheimer’s is the 6th leading cause of death in the United States. There are many symptoms that come along with Alzheimer’s

As such, Alzheimer’s disease accounts for being one of the major contributing factors in dementia. In fact, Alzheimer’s disease accounts for around forty to seventy percent of dementia symptom diagnoses (16). With each year, the number of individuals being diagnosed with Alzheimer’s disease continues to rise. This number is only expected to keep escalating, with a prediction that one in eighty-five people will suffer from the disease by the year 2050

In 1906, Dr. Alois Alzheimer had a patient named Auguste D. He described this patient by saying she had “profound memory loss and unfounded suspicions about family” (Alzheimer, 1906). After his patient had died, he performed an autopsy to rule the cause of death. Alzheimer claims he found “dramatic shrinkage and abnormal deposits in and around the nerve cells”. His findings set new standards for understanding neuro-degenerative disorders around the world. In 1910, this newly discovered abnormality was coined as “Alzheimer’s Disease” (healthline.com). Researching soon ensued and scientists now had more information than ever. In 1976, Alzheimer’s was recognized as the most common cause of dementia. By 1984 Beta-amyloid was found present in brain

The amyloid cascade hypothesis is the most widely accepted of the AD pathogenesis hypotheses. Its principle is that the accumulation of Aβ plays a major role in AD pathogenesis, and the disease is analyzed as a series of abnormalities in the process and secretion of the amyloid precursor protein (APP), where an inequality between production and clearance of amyloid β is the triggering event and the most important factor responsible for other abnormalities observed in AD (Hardy et al, 2002; Cummings et al, 2007). Amyloid β is a peptide with high resistance to proteolytic degradation. It consists of 37–43 amino acids with different isoforms (Deane et al, 2009). Aβ is the result of sequential cleavage of the amyloid precursor protein (APP), generating