Skin And The Human Body

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Skin, the largest organ in the human body covers the whole body. It has many function such as protecting as barrier against radiations, pathogens etc. Skin mainly consists of 3 layers, epidermis, dermis and hypodermis. Epidermis is the outer layer of the skin which is comparatively thin and tough. Epidermis does not have blood vessels and comprised of epithelial cells. Most of the cells in the epidermis are keratinocytes. Epidermis is originated from the deepest layer of the epidermis called basal layer. New keratinocytes slowly migrate up toward the surface of the epidermis. Upon reaching the skin surface, keratinocytes will gradually shed and will be replaced by new cells. Stratum comeum is the topmost layer of the epidermis. It is…show more content…
Langerhans cells are also part of the epidermis, which is the part of the immune system of the skin. They help to detect the foreign substances and aid the body against infection and also it will also take part in development of skin allergies. The epidermis and dermis is separated by basement membrane.
Basically there are two types of skin cancer: melanoma and non-melanoma skin cancer. Melanoma skin cancer is developed from the melanocytes which are located at the basal skin layer. Non melanoma cancer is further classified into two basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). It is BCC occurs mainly on arms, ears, face and neck where the sun exposure is more. Basal cell carcinoma looks as slow growing, translucent elevated lesions (Rubin, Chen (2005)). It is also found that the lesions can be cystic, multicentric, nodular, superficial, pigmented, and ulcerative.

Risk factors
There are any factors that lead to the onset of epidermal carcinogenesis. Ultraviolet radiations play a vital role in developing skin cancer. UV radiations can lead to mutations and alter the signaling pathways. Chances of occurring cancer increases with aging. With respect to this, chances to get SCC is more than BCC. Smoking, alcohol, radiations also contribute to the development of epidermal carcinogenesis. Impaired and suppressed immune system also carcinogenesis particularly SCC. It is found that chances of developing non melanoma cancers like BCC and
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