Skin Regeneration Paper

This is a 52-year-old male with a 9/24/2014 date of injury. A specific mechanism of injury has not been described.

The main outcome measures were the percent area of the wound compared to baseline area of the wound. As the wound decreased in size it is theoretically assumed that the wound is healing. The central concepts of the study were based on ultraviolet-C positive effects on wound healing in vitro. In vitro studies effects include; modification of growth factors, fibronectin release from fibroblast, epidermal cell proliferation, killing of pathogens, accelerated DNA synthesis, and antibiotic-resistant organisms.

For my practice I was fortunate to be able to work at the Bethany in Cochrane. This facility was well kept and has much of the equipment to properly and holistically care for their residents. While in practice, I was able to help with a variety of tasks, including morning care and bed making. An essential element of morning care was a skin assessment, typically to look for bruises, dry spots, and most importantly, ulcers. Ulcers are painful and can decrease quality of life (Ricci, 2013).

In light of how incredible our body is to be able to regenerate quickly for most, that is not what happens for others. Many diseases or large body wounds can take years to make it through one stage. Some may not ever heal. Wounds such as diabetic, venous stasis, ischemic, or pressure ulcers have a lack of blood flow making it almost impossible for them to heal naturally (Cutroneo, 2008). Large area burn victims also fall into this category. Their body is trying to compensate for fluid loss and maintain homeostasis, but wound healing ends up being very difficult to do on their own (Jacobsen, 2005). Many attempts are used to heal these including gene therapy, hydrotherapy, hyperbaric oxygen therapy, and topical antibiotics to just name a few. There are many courses of therapy to heal these wounds, and some work better than others depending on the wound and person.

The main outcome measures were the percent area of the wound compared to baseline area of the wound. As the wound decreased in size it is theoretically assumed that the wound is healing. The central concepts of the study were based on ultraviolet-C positive effects on wound healing in vitro. In vitro studies effects include; modification of growth factors, fibronectin release from fibroblast, epidermal cell proliferation, killing of pathogens, accelerated DNA synthesis, and antibiotic-resistant organisms.

This study considered a skinfold assessment performed at the right triceps and the measurement of the body fat percentage by mean of a Bioelectrical impendance machine (BIM). This is a more complex method. It is hypothesised that there is a positive linear relationship between skinfold thickness and body fat

More specifically, the body recognizes the antigen proteins on the connective tissues as damaged tissue or foreign bodies. As a result, the autoimmune system goes into its defense mode which is a hyperactive state. In this state, it produces an excess of antibodies and growth factors. Growth factors are a hormone or substance that is required to stimulate growth or synthesis in cells. The specific chemicals that are produced are cytokines and chemokines. Furthermore, cytokines and chemokines which are produced in the blood are the chemical growth factors that assist with scar tissue repair by defending the body. It does this by stimulating the

Early studies done by F. Pepper in 1954 supported this correlation as wounds, where the hair follicles were present and intact, were observed to heal more quickly [2,4]. Hair follicles are considered as the miniature organ that is responsible for the growth of hair and the re-epithelialization of wounds. These follicles undergo three different stages of growth (anagen, catagen, and telogen), with anagen being the growing phase of the cycle. During the anagen phase of the hair follicle cycle, acceleration of wound healing process is observed [5]. One growth factor found in skin cells of limited quantities in humans, referred to as fibroblast growth factor 9 (fgf9), is reported to trigger the formation and regeneration of hair follicles in the healing of a wound. The hair follicles will then signal for the accumulation of fat cells, which in turn will help regenerate skin with similar texture as the surrounding tissue [6]. This experiment aims to further report a functional link between hair follicles and tissue repair by observing the effect of fgf9 on wounded skin. Most research that has been conducted following this topic used mice as their model organisms, however I will be using pigs as my model because of their anatomical similarities to humans. I hypothesize that if enough fgf9 serum is given to pigs with cutaneous wounds, then there will be a significant

Skin is largest organ of human body which is base of fifth sense of this body. Skin provide interface to the mind to feel and respond to various kinds of touch. These responses are coordinated by mind to skin. You can very well interpret about which type of touch your skin is experiencing. Well this vital organ of body need to be protected from any sort of infection and environmental effects. Skin issues arise by reaction of cell membranes of skin with ultra violet rays of sun or from other harmful chemical of alien substances. This reaction damages your skin; its immediate cure becomes necessary. There are many skin centers which can help you out in your skin problems. But you need to go for trustworthy centers who work along with promising for best

There are so many clinics today providing many different medical services. For example for just getting ultrasound Bakersfield, there are many clinics. Similar is the case with dermatology clinics. The tremendous increase in the popularity of the skin rejuvenation treatment has made this sector a super-expanding one. However choosing a proper place and professional to get this treatment will surely impact the results. You have to research well and find an appropriate clinic to get the best treatment for yourself.

“The process by which tissue repair takes place is termed wound healing and is comprised of a continuous sequence of inflammation and repair, in which epithelial, endothelial, inflammatory cells, platelets and fibroblasts briefly come together outside their normal domains, interact to restore a semblance of their usual discipline and having done so resume their normal function”. ("The Cellular Biology of Wound Healing" 2016)

According to Brown & Phillips (2010) several biological process in the skin require nutrients for proliferation. The

Many studies on wound healing stages have found abnormal changes in remolding stage, and the main change in this stage was the imbalance in collagen production and degradation. This imbalance in collagen production and degradation was hypothesized to be the cause of keloid scars formation. Although many studies have been conducted on keloid in order to understand its pathophysiology, the full picture of keloid pathophysiology still unclear yet. For the sake of keloid treatment, many treatment regimens were invented to overcome formation of keloid scar as a complication after wound healing. Although there have been many scholars work on finding a treatment for keloid, there are many obstacles to reach the complete cure and avoid recurrence. Keloid treatments were categorized into three categories. These categories are noninvasive medical therapies, surgical and other invasive therapies, and therapies under investigation. In Noninvasive medical therapies category, the majority of treatments in this category exert their effects mainly throughout repression of the fibroblast proliferation rate, ECM synthesis, collagen synthesis, inflammation, enhancing of MMP expression in order to reduce the keloid scar formation. Surgical and other invasive therapies category, although this type of treatment is very popular, it has a high rate of recurrence when it is used alone. Many studies on keloid have shown that the combination therapy is the best therapy, and it has been shown that it reduces the rate of recurrence. For instance, combination of cryotherapy therapy or the surgical management with corticosteroid or 5-Flourouracil therapy was found to give clinical outcomes better than use of either therapy alone. Therapeutic under investigation category, it is including all new therapies

As the inflammation receds the proliferation phase begins, in this phase of healing, cellular activity predominates. The major events during this phase are the creation of a permeability barrier (ie, reepithelialization), the establishment of appropriate blood supply (ie, angiogenesis), and strengthening of the injured dermal tissue (ie, fibroplasia). Reepithelialization is the process of restoring an intact epidermis after cutaneous injury. It generally involves several processes, including the migration of adjacent epidermal keratinocytes into the wound. Epidermal stem cells from the hair follicle are now thought to originate from the hair bulge that is believed to be the germinative portion of the hair and serve as a reservoir for keratinocytes

Wound healing is a dynamic process consisting of four continuous, overlapping, and precisely programmed phases. The events of each phase must happen in a precise and regulated manner. Interruptions, aberrancies, or prolongation in the process can lead to delayed wound healing resulting in a non-healing chronic wound.