Smallpox : Pathogenesis and Pathology Essay example

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Smallpox: Pathogenesis and Pathology Smallpox was eradicated in 1980 by the Center for Disease and control. It is now contained in five labs in the United States and Russia, however there are other labs in the world with smallpox. Smallpox is created from the virus Variola which inoculates itself through the skin and into the dermis or more commonly from prolonged, direct face to face contact. Smallpox incubates for as long as two weeks at which time it is multiplying in the lymph nodes and bone marrow. The virus is also able to enter the blood stream and travel through without being harmed by macrophages. The variola virus also causes monkeypox and cowpox however none of these are as bad or as fatal as smallpox. Smallpox is…show more content…
Once the T cells destroy some infected cells, they create virions, or inert carriers that act as a spacecraft for the virus to travel from cell to cell without being harmed by the hostile conditions of the human body. After this point the individual becomes ill with smallpox. There have been cases where a subject’s immune system could launch an early cell immune response and recovered much more quickly and without as much pain as other subjects who became critically ill (Aguayo) It is unknown how large the infectious dose of smallpox is, but it is very small. Once the virus enters the human, it migrates to the lymph nodes and begins to multiply. On the third and fourth day of infection the virus causes asymptomatic viremia, or the presence of a virus in the blood stream that is not causing any symptoms. At this point the human is not infectious and shows no symptoms. On the eighth day of infection the virus begins another viremia followed by a fever above 100 degrees Fahrenheit s well as toxemia, or a presence of an abnormality in the blood (Mayo Clinic). The incubation period of the smallpox virus is from twelve to fourteen days at which time the person is not infectious. Once the incubation period ends, the person develops a fever, as previously stated, followed by lesions on the skin. The lesions appear first in the mouth, releasing large amounts of the smallpox virus in the saliva making the person

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