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Smallpox: The Variola Virus

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Smallpox has been a feared disease throughout history due to huge epidemics resulting in a large number of deaths (Carson- Dewitt 2006). The name Smallpox, or the Variola Virus, was common around 570 AD and introduced by Bishop Marious of Avenches. Variola derives from the Latin word various meaning stained or various or mark on the skin (Milton 2012). Milder patterns of the virus can be called cotton pox, white pox, and the Cuban itch (OMICS International 2006). The word smallpox was first used in 15th century England in order to tell the difference between syphilis called “great pocks”, and the variola virus (Riley 2006).
Smallpox is believed to have first appeared around 10,000 BC and spread by Egyptian merchants. The earliest evidence …show more content…

People with smallpox are highly contagious during the first week because of the large amount of virus present in their saliva. Contaminated clothing in bed linen can also spread the virus, although it is less common and less effective (Carson-Dewitt 2006). Incubation of the virus can last two weeks and show no symptoms. In the latent period the incubation can last four to fourteen days while the virus multiplies. The prodromal stage occurs next. This is when the mouth and skin become infected. The prodromal phase can last two to three days (Breman & Henderson 2002). After the incubation is finished the virus erupts from infected cells releasing particles which in turn go on to infect other cells in the body. The symptoms will then appear abruptly as body parts are increasingly taken over by the virus (Carson-Dewitt 2006). The bodyś immune system tries to ward off the persistent symptoms and causes a fever to occur. Large amounts of the virus can be found in organs such as the spleen, lymph nodes, liver, bone marrow, and kidneys (Breman & Henderson 2002). The viruses linear genome consists of roughly 200 genes involved in the replication of the virus within the body. The variola virus belongs to the genus Orthopoxvirus which its members produce lesions on the skin of mammals (Bray & Buller 2004). Smallpox is strictly an infection that affects human beings. It does not affect animals …show more content…

Coagulopathy is a condition in which the blood's ability to coagulate or form clots becomes impaired. This condition can cause prolonged or excessive bleeding (Tomislav 2015). These are caused by an inflammatory response to the virus affecting cells in the body (Bray & Buller 2004). Bacterial infections from the open skin lesions, bone infections, and pneumonia are major factors contributing to the death rate of smallpox (Carson-Dewitt 2006). Death occurs in 30% of smallpox cases (Turkington & Ashby 2007). Pitted lesions are visible on the body of survivors dating back to the 1000 BC (Berman & Henderson 2002).
The smallpox virus can be mistaken for scabies chicken pox or herpes. The electron microscope can see the virus within the patient's urine or blood before a rash has developed. If progressed enough a physical examination would be able to determine the virus (Carson-Dewitt 2006). The characteristic rash along with known exposure to the virus were important factors when diagnosing patients with smallpox (CDC

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