Sodium Difficile Research Paper

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Clostridium difficile colitis results from a disruption of the normal bacterial flora of the colon, colonization with C difficile, and the release of toxins that lead to mucosal damage and inflammation. Antibiotic therapy is the key factor that is responsible for altering the colonic flora and allowing C difficile to flourish. Colonization of C difficile occurs through the oral-fecal route after antibiotic therapy has made the bowel susceptible to infection. After colonization, the organism releases two protein exotoxins into the colonic lumen. Approximately 75% of C difficile strains produce two toxins, A and B, that are responsible for causing diarrhea and colitis. Toxin A is an enterotoxin responsible for the colitis that allows Toxin B,
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