Software Essay

In our recent negotiation, my partner Dave and I assumed the roles of Alan Hacker, a computer software developer, and Alan Hacker’s lawyer. Being the lawyer in the negotiation my objective was to avoid litigation with my client’s partner Stanley Star and to aid in the continuation of my client’s co-owned company HackerStar. In addition, I would assist Hacker in coming to an agreement that would be satisfying for him both personally and financially. I felt that Dave and I presented a reasonable argument on Hacker’s behalf and, since I was able to apply some of our class readings during the process, I was overall pleased with the outcome.

It is important to pursue functional validation because even though at a cellular level the cells look like they are doing what they are supposed to do they might not have full functionality. In some cases partial functionality is the same as no functionality.

Proteins are biological macromolecules made from smaller building units called amino acids. There are 20 natural occurring amino acids which can combine in various ways to form a polypeptide. There are four distinctive levels of protein structure: primary, secondary, tertiary and quaternary. The primary structure of a protein is important in determining the final three dimensional structure and hence the role and function of a particular protein, both in the human body and in life around us. The secondary structure of a protein can fall into two major categories; α-helices or β-sheets, other variants also exist such as β-turns {{20 Brändén, Carl-Ivar, 1934- 1991}}. The precise folding or these secondary structures into a three dimensional shape is known as the tertiary structure of a protein and multiple polypeptides bound together via covalent and non-covalent bonds forms the complex quaternary structure of a protein.

Based on recommendations from committee, implement and test the changes to the drug interactions in the software

. The 3-D tertiary structure of polypeptide proteins globular and is the result of interactions that occur between R groups. Tertiary structure is a result of the bonds between sidechains of amino acids, the R groups. The structure and bonds involve alpha helices, beta pleated sheets, and also regions unique to each protein. Tertiary proteins are held together by four different types of forces; hydrogen bonds, hydrophobic interactions (including Van der Waals interactions), ionic bonding (electrostatic interactions), and disulfide bridges (strong covalent bonds). Hydrogen bonds occur within and between polypeptide chains and the aqueous environment. Hydrogen bonding forms between a highly electronegative oxygen atom or a nitrogen atom and a hydrogen atom attached to another oxygen atom or a nitrogen atom. This links the amino acid

Laboratory errors have a negative impact on the patient and the healthcare system. Errors result in wasted time, resources and supplies, decrease efficiency, and pose increased risk to the patient (Osborn, 2017). While there are three phases in the laboratory practice where lab errors can occur, pre-analytical, analytical, and post-analytical, the pre-analytical stage is where the majority of lab errors transpire (Hammerling, 2012). The pre-analytical phase is composed of many steps that occur both before and after the specimen reaches the laboratory (Kaushik & Green, 2014). The complexity to this phase contributes to the pre-analytical phase being the most error prone part of laboratory

When studying medicine it is important to know how the pharmaceutical drug will affect the body, how quickly the drug will work, and what are the short term and long term effects of the drug on the disease. It is important to know the structure of the molecules, to see exactly where the inhibitor will bind, or if it will even bind at all. In the experiment, Structure Based Approach to the Development of Potent and Selective Inhibitors of Dihydrofolate Reductase from Cryptosporidium, they studied the crystal structures of the inhibitors and used computational analysis to determine which in inhibitor would bind the best. The overall goal is to make sure that the inhibitor binds to the correct active site, and that it is the only site.

Introduction: The goal of this experiment was to practice using the FirstGlance in Jmol molecular visualization to examine key structural features of proteins. This work is important because protein structure can be related to function, multiple-sequence alignments and evolutionary preservation, and designing drug. FirstGlance in Jmol makes it fairly easy to perceive structure-function relationships in the protein you chose. Using FirstGlance, it is easy to visualize and distinguish chains, and disulfide bonds are obvious. Alpha helices and beta strands are evident due to the "cartoon" secondary structural schematic.

Most of the angles we calculated in the molecular geometry section of our lab were similar to the ones we predicted in Section II.C. For example, our model for ClF5 was predicted to have less than a 90 degree angle and our calculated result on the computer was 87.52 degrees. Also, the CO32- predicted model was 120 degree angle and we got 119.99 degrees which rounds up to the predicted model. However, some of the angles we calculated did not agree with the predictions we made. For example, CH3OH was predicted to have a bond angle of less than 109.5 degrees for both the C and O bond but our computer model showed an angle of 120.08 degrees for the C bond and 163.40 for the O bond. In the beginning of

The Validation Team is responsible for collection of swab samples and ensuring any failures to meet acceptance criteria are addressed immediately. Any deviations from this protocol and any additional testing due to failure will be included and reviewed in the final cleaning validation report CVR-049.

The primary protein structure can be likened to a human chain in which each person is assumed to be an amino acid and their hands viewed as the carboxyl and amino groups. The person on one end of the chain, who has a free left hand, is assumed to be the free carboxyl group. The person on the other end, who has a free right hand, is assumed to be the free amino group. Everyone in this chain has a left hand linked to somebody’s right hand and a right hand linked to somebody else’s left hand forming peptide bonds. The heads and legs just like the side chains and hydrogens, do not take part in the linking.

In Roberto Tejero’s lab, students were investigating Protein structure assurance by NMR techniques includes reconciliation of an extensive range of programming apparatuses. The heterogeneous exhibit of programming instruments utilized as a part of the procedure of protein NMR structure assurance presents authoritative difficulties in the structure assurance and approval forms, and makes an expectation to absorb information that constrains the more extensive utilization of protein NMR in science. It also shows a coordinated arrangement of computational strategies for protein NMR limitation investigation and structure quality evaluation, relabeling of prochiral iotas with remedy IUPAC names, and additionally numerous techniques for

In this method of protein designing the scientist uses the already available details and was knowledge of the structure and function of proteins to make the necessary desired changes, Generally and technically it is comparatively inexpensive and easy because site directed mutagenesis techniques are well known and well defined and well developed however the flip side of the coin is detailed structure and functional knowledge of the protein in discussion is required which is open and available and even when available in general it can be extremely difficult due to difficulty in production of various mutation

September 13 is the day of the programmer. A day in which we celebrate the clever, and often mysterious, work programmers achieve that help the modern world keep spinning. Programmers come in many forms, from web developers and front-end developers (those who take the design of a website and bring it to life using an array of languages such as JavaScript, HTML and CSS) to software and application developers (those who gather feature requirements for software, design a solution and implement the intended features).

The various types of check sheets are Recording check sheet, check list, Process check sheets, Defect check sheets, Stratified defects check sheets, Defect location check sheet, Cause and effect diagram check sheet. (Thomas Pyzdek 2015)