Statistical Package For The Social Sciences ( Spss )

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All the experimental results were compared by one-way analysis of variance (ANOVA) using the Statistical Package for the Social Sciences (SPSS, ver. 22.0, SPSS Inc. Chicago, IL, USA). The data were are expressed as means ± SEM. Group means were considered to be significantly different at p < 0.05, as determined by the technique of protective least significant difference. Results 3.1. HPLC Profiles of BGE. To investigate the stability of the BGE water decoction, we repeated the same extraction step was repeated times to obtain BGE and then determined the berberine hydrochloride content in BGE was detected by HPLC analysis and at a dectection wavelength of 203 nm with a C18 column (Fig. 1). The content of ginsenosides such as ginsenoside Rg5, Rk1, and Rh4 in BGE are summarized in Table 1. These unique ginsenosides are nonexistent in white ginseng. The major ginsenosides, including Rb1, Rb2, Rc, and Rd in white ginseng can be transformed to minor ginsenoside Rg3, by and than then ginsneoside Rg3 is converted to Rg5 and Rk1 by heat-treatmentheating (1). In particular, delycosylated minor ginsenosides have more pharmaceutical activities than major ginsenosides (2). 3.2. Improvement effect of BGE about Fasting glucose levels and Glucose Intolerance in type-2 diabetes model. To confirm the effect of BGE on the development of diabetes, fasting blood glucose levels and glucose tolerance were was investigated in Type 2 diabetic db/db mice. Before BGE were was administered to mice,
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