How Do Mayo Clinic Use Stem Cell Therapy For Heart Failure?

Heart failure is when the heart cannot keep up with the immense demands placed on it by the body, and it starts to compensate causing remodeling of the cardiac cells due to stronger cardiac contractions. The heart chambers expand so they can fill with more blood to pump to the rest of the body, and the heart rate will increase to meet these demands (American Heart Association, 2015). Heart failure is the inability of the heart to fill and pump effectively enough to meet the metabolic demands of the body resulting in pulmonary and venous congestion (Lam et al., 2007). Over time the body can no longer compensate, and the person becomes symptomatic and progresses into worsening heart failure. The pulmonary and venous congestion or “fluid overload” will manifest itself in the form of lower extremity edema, shortness of breath, fatigue and even chest pain, which interferes with quality of life (Colucci, 2015).

The stem cells were engineered from typical skin cells. This technique means that heart patients would not have to worry about rejection. Their new hearts would be made of their own cells.

Heart failure is a long-term (chronic) condition in which the heart cannot pump enough blood through the body. When this happens, parts of the body do not get the blood and oxygen needed for them to function properly.

Stem cells have made significant promise to help people understand and treat a broad range of injuries, diseases, and other health-related issues. This type of treatment has saved the lives of many people with leukemia and can also be used for tissue grafts to treat conditions with the skin, bone and surface of the eye ("Nine Things to Know about Stem Cell Treatments"). Dilated cardiomyopathy (DMC) is a disease characterized by expansion of the left ventricular chamber and it is usually associated with systolic dysfunction. The presentations of the condition include heart failure, myocardial infarction, and arrhythmia and as a refractory life-threatening condition which can cause heart failure, transplantation remains the ultimate therapy for

the aftermath of a heart attack. Virtually any disease could be treated or even cured through stem

Therefore, much of the critic’s arguments are invalid due to the fact that the embryo won’t develop into a child. Stem cells are the beginning of an enormous scientific breakthrough, a breakthrough that critics are simply putting off. Embryonic stem cells have the potential to treat some of the worst diseases we face today, such as cancer. Many critics argue that adult stem cells offer a good alternative. However, adult stem cells have become specialized and only have the ability to become specific type of tissue. Unlike adult stem cells, embryonic stem cells have the ability to create any type of cell within the body, as well as replicate themselves. This difference is proof alone that embryonic stem cells are vital to treating the more complex illnesses. Due to this, embryonic stem cells would create a larger bank of replacement cells and tissues. This is important because although there is organ and tissue donation, there is a higher demand for them than we have to supply. With embryonic stem cells, there would be more available treatment for patients with diseases such as macular degeneration, spinal cord injuries, heart disease, and more. In the case of heart disease, with the use of embryonic stem cells, healthy heart tissue could be generated in the lab and then transplanted. This would lead to a quicker treatment option than waiting for an available tissue and organ through

A late survey of 23 trials including 1255 individuals with coronary illness found that there is some proof that beneficiaries of stem cell treatment are less inclined to kick the bucket or be readmitted to healing facility a year or more after treatment than individuals who got a proper standard

In order to obtain relevant information to support this topic, databases including PubMed, Medline, UpToDate, and Google Scholar were used. Terms used in each search included and combined the following: mesenchymal stem cell, cardiac stem cells, HF, heart repair, ejection fraction, cardiac output, cardiac index, mortality.

From the medical perspective, stem cell research is viewed as very promising due to the fact that if stem cells can be introduced into patients with a range of illnesses, they could possible help regenerate the tissues and organs of the patients and thereby help heal illnesses (and especially degenerative illnesses) that are currently incurable. For example, Lovell-Badge has indicated that diabetes, Parkinson's disease, and Huntington's disease are among the illnesses that could

Heart failure refers to the reduced functioning of the heart because of a previous heart attack or a long history of heart disease. It is more common for a person to have a lengthy history of heart problems for it to develop, but it can happen after one massive heart attack if the heart attack does a significant amount of damage. The heart is responsible for pumping blood through the arteries to oxygenate all of the organs and the brain, so if it isn't working as it should, there can be some dire consequences to one's health. Though it is treatable, most cases of heart failure are not reversible. But there are some ways that a person can improve their quality of life while they have the condition, though.

Rather than relying on surgical methods meant to replace these tissues, scientists are now beginning focus on new methods that actually allow the heart to repair and replace damaged tissue. In the June 29, 2006 edition of the journal entitled, Nature, Dr. Kathryn Ivey of the Gladstone Institute of Cardiovascular Disease explains, “the ability of circulating cells to produce factors that are sufficient to invoke cell survival or repair responses in damaged heart cells” remains a primary objective of research cardiologists. By manipulating synthetic compounds meant to catalyze the regeneration of tissue, the new experimental method of repairing heart muscles may be able to abandon surgical procedures altogether. While the vast majority of attention is being spent on the ability to use stem cell therapy to repair congenital heart defects, some scientists are exploring alternative possibilities in organisms like the

Stem cell research can further develop therapy for those in need. Stem cells are undifferentiated cells that are able to develop into any type of cell in the body, since they are able to do so they are one of the major factors in healing ourselves. Despite the hard work stem cells are able to do, people suffering from a major disease may not produce enough cells to fully heal and could look into stem cell therapy to get extra cells to help them heal completely. The therapy is done by transplantations, one is called nuclear transfer it is done by taking the patient's DNA of a cell and transferring it to an egg cell then the egg is placed in a culture dish and when the process is done the cells are re-introduced into the patient and are able to assist in the healing process. Someday using the therapies could possibly create

“Through the isolation and manipulation of cells, scientists are finding ways to identify young, regenerating ones that can be used to replace damaged of dead cells in diseased organs. This therapy is similar to the process of organ transplant, only the treatment consists of the transplantation of cells rather than organs. The cells that have shown by far the most promise of supplying diseased organs with healthy cells are called stem cells.” (Chapter Preface)

Millions suffer from many different diseases and problems. What if a cell can possibly fix it all? Scientists are believing that stem cells can be very helpful in the cure to many of these situations. Alzheimer’s disease, heart disease, spinal cord injuries, and hundreds of other genetic disorders are thought to be cured by stem cells. After a heart attack, the

In these treatments, the stem cells undergo laboratory treatments that enable them to become cardiac cells. The treated cells are thereafter injected into the heart of patients to allow for the growth of healthy heart tissues. The research is the first successful show among people that adult stem cells can be transformed into cardiac cells. The discovery has also been found to be successful in the lives of millions of people. According to the World Health Organization (WHO), cardiovascular disease is the number one killer disease in the whole world. In the United States alone, more than 5.8 million people suffer from this condition.