Steve-Johnson Syndrome: A Case Study

Adverse reactions to drugs are common and almost any drug can cause an adverse reaction.

Hutchinson-Gilford Progeria syndrome, also known as HGPS, or Progeria, is a very rare genetic disease caused by a mutation in the cell. In 1886, Jonathan Hutchinson first reported case of a 3 ½ year old boy who had the appearance of an old man. In 1897 Hastings Gilford reported a second case with similar features. However, this mystery disease didn’t have a name until 1904, when it was named after the two men. People who have HGPS usually star showing symptoms by the age of 2, and only live to be a teen-mid-20s.

Usher syndrome is a genetic disorder that causes its victims to get retnis pigmentosa (RP), or a disease that affects someone’s retinas resulting in tunnel vision, and hearing loss. The most common gene that becomes mutated is gene USH2A, this is a protein producing gene. It is a mutated recessive gene, meaning that in order to inherit Usher syndrome both parents have to be carriers of it. Once the child gets Usher syndrome, they will experience loss of eyesight and hearing.

Shawn Johnson’s birth was frightening for her parents as her health was alarmingly low. Though she

In the Johnson case, Mr. Johnson and his son, Sam went shopping and were falsely accused of stealing. They went to the mall and then directly to Target after the mall. After adding multiple items to the shopping cart, the previous items bought got mixed in with the items to be purchased. Upon leaving Target, Mr. Johnson was approached by a security guard who loudly accused Mr. Johnson of stealing. The security guard was loud enough for others to hear him. He also roughly pulled on Mr. Johnson’s arm telling him to go with the store manager or he would call the police. It took two hours for the store manager to prove Mr. Johnson did not steal the video game and the figurine.

A 76 years old woman who was described as a healthy and active for her age Helena Lambert, from Ceston, BC was killed by an adverse interaction between two prescription drugs which was overlooked by health professionals she trusted, according to CBC. Helena’s doctor prescribed allopurinol to treat her gout however, Helena was also on mecartopurine, an immunosuppressant for colitis. After six weeks starting her new medication, she developed a blister on her foot. Her son took her to Creston Valley Hospital, where doctors found out the interaction between the two drugs causing Helena immune system to shut down. Her son said his mom suffered before dying from the infection and respiratory failure.

Alström Syndrome is a life-threatening disease that result in a progressive loss of vision and hearing and other metabolism disorders. This condition is caused by a mutation that occurred in the ALMS1 gene. The mutation in ALMS1 gene causes the loss or degradation of the protein ALSM1 which result in a defective tissue homeostasis. The defective tissue homeostasis leads to the atrophy of stria vascularis along with the loss of intermediate cells, and the degeneration of outer hair cells. The disease-associated protein ALMS1 localization at the basal bodies of hair cells, differentiating fibrocytes, and marginal cells in the cochlear lateral wall suggest that ALMS1 proteins play a role in cilium-dependent planar cell polarity signaling. Indeed,

The number of seniors in the United States is growing rapidly. The costs to cover medical expenses is increasing as well, causing many family members to become caregivers. Unfortunately, without receiving specialized training, some seniors may be at a disadvantage when they receive care from their family members. Caregivers must recognize the signs many seniors exhibit when it is time for a community that focuses on senior living in Virginia Beach.

Johnson-Munson syndrome is a rare syndrome identified by missing abnormal vertebrae, fingers and toes and various deformities of the heart, lungs, intestines, pancreas and intestines. Ophanet a consortium of European partners defines a condition as rare. In the US population, less than 200,000 people can possibly be affected by Johnson Munson Syndrome or second type of Johnson Munson syndrome. (Orphanet 2015)

SJS and TEN are severe mucocutaneous reactions, most commonly triggered by medications, characterized by extensive necrosis and detachment of the epidermis. The two conditions are distinguished based on severity, which is scaled by evaluating the percentage of body surface area involved in the blisters and erosions. SJS is the less severe and more common condition with 30% of the body surface with mucous membranes involved in the majority of cases. The mucous membranes were not involved in this patient making SJS and TEN less likely. However, the mortality rate for SJS is 10% and TEN is 30%, which is why it was important to rule out these conditions before sending the patient home. Although SJS and TEN are usually triggered by medications, one study showed that approximately 20-25% of pediatric cases could not be clearly attributed to a drug. While this patient’s history does not indicate any new medications, we cannot simply rule out the possibility of SJS or TEN for that

Maxwell called his daughter's pediatrician in order to see what he had to do to keep his daughter comfortable. Despite the fact that Chelsea was sick, she was in great spirits at first. She was not crying, screaming or whining. Things took a turn for the worse when they went to the grocery store. Chelsea started throwing up everywhere.

Stevens-Johnson Syndrome, a form of Toxic Epidermal Necrolysis, is a rare life-threatening disorder of the skin and mucous membranes which arises from an intense autoimmune sensitivity to mild infections, cancers, and most commonly, medications.

Brandi Johnson arrived for the group that was held on 8/16/16 at approximately 8:50 am. Brandi came to the group room and asked if she could still come in. Brandi stated that she left her house and was sleeping in her car because she was being bit by bed bugs. Brandi further stated, “I have been looking for housing but have not been successful. I slept in my car; my phone went dead so my alarm could not go off. I do not want to get kicked off the program because of the days that I have missed.” I told Brandi that she couldn’t enter group because she was late. I redirected Brandi to talk to Mike Turner on Monday morning.

HLA-B*58:01 allele has been found to be a huge risk factor for allopurinol-induced Steven’s Johnson Syndrome.4 Elderly women with renal dysfunction is indicated to be a risk factor for allopurinol-induced Steven’s Johnson Syndrome.4 The strength of allopurinol has been noted tto be a risk factor. The daily dose of 200 mg or greater has been associated with a higher risk of developing this hypersensitivity reactions.

Zollinger-Ellison syndrome, is known as the gastrinoma syndrome caused by gastrin-secreting tumors of the pancreas, which stimulate maximum acid secretions and lead to ulcerations. ZES is connected with diarrhea, malabsorption, gastric reflux, severe ulcerations and ulcerations in the duodenum and the proximal jejunum. There are a few types of ZES that exist in different forms, including benign, sporadic, metastatic, and part of multiple endocrine neoplasia type 1 (MEN 1). Most gastrinomas are sporadic and sporadic tumors are a cancer that occurs in people who do not have a family history of that cancer. Sporadic gastrinomas are located at the gastrinoma triangle, which is located in the junction between the cystic and bile duct, portions of the duodenum, and the pancreas. While solitary tumors can