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Stevens-Johnson Syndrome

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Stevens-Johnson Syndrome, a form of Toxic Epidermal Necrolysis, is a rare life-threatening disorder of the skin and mucous membranes which arises from an intense autoimmune sensitivity to mild infections, cancers, and most commonly, medications.

Stevens-Johnson Syndrome is extremely rare, affecting between 2.6 to 7.1 people per million each year. The disorder can affect anyone, however, studies show that SJS is twice more common in females, more common in caucasians, and elderly people as they are more likely to use the medications that cause it. The condition is 100 times more likely to occur in people who are HIV-positive and those with systemic lupus erythematosus,

SJS is not an inherited condition. However, the genetic changes that
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Topical care can include antiseptic solutions or ointments that act as disinfectants. Fluid replacement and nutrition is critical for healing, and the majority of patients are unable to drink and eat, they may receive fluids through a nasogastric or gastric tube. Due to the risk of eye problems, an ophthalmologist is consulted to evaluate the…show more content…
It is believed individuals may have a genetic predisposition to developing these disorders. A genetic predisposition means an individual carries a gene for a disorder, but it may not be expressed unless it is triggered.

The exact, underlying mechanisms that lead to the symptoms of SJS are not completely understood. It is unknown how individual drugs specifically cause the symptoms of the disorder. Researchers believe that the immune system intervenes in the process of breaking down the drug to which the body is reacting. The improper immune response against the drug results in damage to healthy cells of the body. Keratinocytes, which are the precursor cells that develop into skin cells, are affected in these disorders and are destroyed during the disease process.

The average reported mortality rate of SJS is 1-5%. In order to standardize the evaluation of risk and prognosis in patients with SJS, the SCORTEN scale is now the most widely used scoring system and evaluates age, malignancy, tachycardia, initial body surface area of epidermal detachment, serum urea, serum glucose, and
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