Stevens - Johnson syndrome is a rare immune response in which the person’s epidermal layers die and

1100 WordsApr 23, 20195 Pages
Stevens - Johnson syndrome is a rare immune response in which the person’s epidermal layers die and are shed (Cooper, 2012). It proves to be fatal when not identified early and interventions started. Although, despite early identification and interventions death does still occur. Stevens-Johnson is considered to be part of a spectrum of Severe Cutaneous Adverse Reactions (Knepel, 2008). The other two conditions on the spectrum are Erythema Multiforme at the lesser end, and Toxic Epidermal Necrolysis on the more severe side. TENS can overlap with SJS, along with being used interchangeably by some (Cooper, 2012). Due to the fact that Stevens-Johnson is so rare the information and studies on it are lacking in quantity and quality.…show more content…
Allopurinol is seen with a higher percentage in Asian decent with a genetic predisposition marker (Cooper, 2012). It is thought that genetic predisposition can put certain people at a higher risk. Such as those with systemic lupus erythematous (Mayo Clinic, 2011). Infectious causes of Stevens-Johnson syndrome include: • Pneumonia • Herpes • Influenza • HIV • Diphtheria • Typhoid • Hepatitis (Mayo Clinic, 2011) Infection with Mycoplasma Pneumoniae is most common cause of community acquired pneumonia requiring possible admission to the ICU and is also cited as most common cause for children to develop Stevens - Johnson syndrome (Cooper, 2012). Clinical manifestations include fever, myalgia, rash, papules, macules that lead to sloughing and eventually necrosis, the skin can look like a scalding burn, mucosititis, and respiratory distress from interstitial edema, gastrointestinal issues ranging from diarrhea to ulceration and bleeding, ocular issues such as conjunctivitis to inflammation, photophobia up to and including loss of vision (Cooper, 2012). Any body system that has epithelial tissue can be subsequently affected. The further the condition progresses the higher the degree of mortality. Being alert to the possibility of the condition and trying to get as much information from the patient regarding medication usage, to include over the counter and herbal is vital because time is critical factor (Cooper, 2012). Misdiagnosis

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