Treatment:
The treatment of Strongyloides depends on severity of the infection and the underlying host conditions (Miller et al., 2008).The goals of treatment for strongyloidiasis are to treat symptomatic disease and prevent complications in asymptomatic disease by eradicating the organism and thus eliminate autoinfection (Segarra-Newnham, 2007).To start with, traditional Chinese medicine (‘guan Zhong’, ‘gentian violet’) (Wang et al., 2013), Mebendazole (Reddy and Swarnalata, 2005), and tribendimidine (Steinmann et al., 2008) are the most widely used best treatment available for the uncomplicated infections. However, with advancing knowledge the current treatment options include thiabendazole, albendazole and ivermectin (Grove, 1996; Igual-Adell
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(Igual-Adell et al., 2004).It has also been registered as the drug of choice in the World Health Organization’s list of essential drugs for the treatment of human strongyloidiasis (Albonico et al., 1999).The dosage generally recommended is of 200 mm/kg of body weight administered orally once daily for 1-2 days (Mejia and Nutman, 2012). Treatment is repeated if necessary 2-3 weeks after the first course to ensure eradication of infection (Segarra-Newnham, 2007). Although this is the standard dose administered for the treatment of the disease but the dosing interval and the length of therapy depends on the stage of diagnosis and the severity of the diseases. Also the prompt treatment is essential for improving the patient outcome. Moreover, combined therapy using ivermectin and thiabendazole or ivermectin and albendazole has been recommended in patients with disseminated disease (Segarra-Newnham, 2007). It is important to note there is an issue with Oral absorption of ivermectin in severe strongyloidiasis patients due to hypoalbuminemia, paralytic ileus and sometimes increased drug clearance (Turner et al., 2005). In such cases, it is administered subcutaneously or rectally. The dose for the subcutaneous ivermectin administration is different from the oral administration of the drug. Prescribed dosage
4. The patient was advised to start loratadine 10 mg daily now for itching and also to use 5 or 10% benzoyl peroxide for facial acne.
Drug therapy relies on the principle of selective toxicity, where the effects of the drug are only harmful towards the foreign parasite and not at all to the host. By comparing the effects of different drugs on various parasitic organisms we are able to distinguish the type of disease or infection that is present as well as the mechanism of action that takes place by each drug in question. The drugs may function by interacting with enzymes such as transpeptidase and thymidylate synthetase, for example Penicillin and 5-FU function respectively. The effectiveness can be quantified by measuring the zones of inhibition created by the drug on the plate of the bacteria or fungus. This is the area where there is no growth due to the action of the drug. The discovery that the Micrococcus-luteus is classed as a bacteria was made apparent due to Penicillin’s success in inhibiting it’s growth. The action of the Amphotericin solely on the Pythium, gives reason to believe that it can be grouped with fungal growths.
• the dose to give and how often it may be repeated before referring to the resident’s doctor
The intravenous dosage in this case is 0.5 - 1 mg/kg IV (range: 0.5 - 2 mg/kg).
Use the L-lysine vitamins and supplements as suggested by the label. The dosages vary for a new outbreak or preventive purposes.
Azithromycin (Zithromax) 500 mg IVPB q24h for~ 2 days then 500 mg PO for~ 7 days
The emergency department physician inserts a central venous catheter via the subclavian vein and prescribes Lactated Ringer's solution at 1,000 ml/hr via infusion pump.
Dosages of the drug vary from one extreme to another based upon the patients needs.
immitis tested in mice. Posaconazole orally administered at 0.01, 0.1, 0.5, 1, 5 and 10 mg/kg 3 times a day. Mice had >90% survival when they were treated >0.5 mg/kg. Cultures of whole livers and spleens from mice treated with 10 mg/kg showed >70% sterilization [1].
As this treatment can be used for different purposes, it also comes in different brands and dosages. Therefore, the very most to bear is follow according to the doctor's advice and as prescribed in the label.
Strongyloides stercoralis is a nematode that infects approximately 100 million humans worldwide each year. Infection is endemic in tropical regions.
Elephantiasis is a rare medical condition which is easily identifiable. This is due to effects of the condition which is described as gross enlargement of an area of the body, especially the limbs. This enlargement or extreme swelling of body parts is said to reach seven times the normal size. The enlargement is caused from obstruction of the lymphatic system. The lymphatic system is network of tissues and organs that help rid the body of toxins, waste and other unwanted materials. So, when the condition blocks off the proper function of this system the fluid with toxins build up and causes the gross enlargement.Along with the massive swelling, the skin of the affected area turns dry, thick, and has a pebbly appearance. The disease can be
The patient must be carefully monitored for signs of impending shock. When used as primary therapy for severe bubonic plague, the dosage of tetracycline is 40 to 50 mg/kg per day (in 4 equal doses) after a loading dose of 30 mg/kg. After the first 24 to 48 hours of therapy, the dosage of tetracycline can be reduced to the lower dose. Alternatively, doxycycline can be used in dosage of 2.2 mg/kg twice daily, up to a maximum dose of 100 mg twice daily. Levofloxacin should be given in a dosage of 10 mg/kg/dose IM or PO and Ciprofloxacin in a dosage of 15 mg/kg/dose twice daily IV or 20 mg/kg/dose every 12 hours PO. Chloramphenicol, a less desirable choice, is given at a dosage of 25 mg/kg every 6 hours IV with maximum daily dose of 4 g. Chloramphenicol is preferred only in the treatment of known or suspected plague meningitis or when treatment with tetracycline or aminoglycosides is contraindicated or unavailable. Nonspecific therapy is the same as that employed for patients with other forms of gram-negative sepsis and consists primarily of the treatment of shock, seizures, respiratory problems, and high fevers.
b.ii. The dosage will depend on the age, weight, and other health issues of the person.
Drugs mixed with various adjuvants and administered through the rectal route do provide satisfactory pharmacokinetics with acceptable local tolerance.