Studies of Arizona Insulin Resistance (AIR) Registry
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Arizona Insulin Resistance (AIR) Registry
All study participants were Mexican American from the Arizona Insulin Resistance (AIR) registry. A description of the registry has been discussed elsewhere . Briefly, of the 667 participants enrolled in the study, 353 were distributed across 92 families from the AIR registry. The remaining 314 participants were found to be represented by single individuals. These 314 single, unrelated individuals were considered for the analysis because they contribute to the evaluation of covariate effects. The remaining 353 participants from 92 families generated 723 relative pairs that were distributed across fourteen relative-pair categories (Table 1). Metabolic, anthropometric, demographic and medical history information was obtained on the 667 individuals (aged 8-83 years old) enrolled in the study (Table 2). All procedures were approved by the institutional review board of Arizona State University and all subjects gave informed written consent before their participation.
Blood samples were obtained after a 12 hour fast for assessment of various phenotypes including glucose, insulin, triglycerides, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol. In addition, participants ≥ 12 years of age (n=641) underwent a 2 hour oral glucose tolerance test (2hOGTT) where a solution containing 1.75g/kg dextrose (up to 75 g) was ingested and venous blood