Study The Association Between The Gut Microbiota And Brain Function

2457 Words Sep 30th, 2014 10 Pages
Objectives:
Short term objectives: To study the association between the gut microbiota and brain functions in response to the stress reactivity at different stages of early life. This research will also help to link the brain structures involved in stress reactivity. This research will help to understand, how the diversity and distribution of these prominent phyla contribute to health and disease.
Long term objective: We plan to expand this research to a broader aspect to study the gut-brain axis with simultaneous stress exposure. This research presents a paradigm that is applicable in clinical studies and will provide basis for the psychiatric disorder treatments. Behavioral neuroscientists are increasingly recognizing the importance of the gut microbiota in adaptive immune system in the development of behavior. The microbiota represents individual differences in risk of illness, disease course, and treatment response and will also show how the microbiome in humans differs and/or is similar to that in mice.

Recent Progress:
Discuss with Dr. Foster.

Literature Review:
Over the years, the concept of neuroimmunology and sickness induction behavior (Capuron et al 2003; Capuron et al 2004) in pre-clinical and clinical studies (Maxeiner et al., 2009) has expanded. In animal model studies that administration of IL- 1β (Wang and Dunn, 1999), TNF –α (Ebisui et al., 1994) or Lipo-polysacchrides (LPS; Quan et al., 1999) alters the hypothalamic-Pituitary-Adrenal axis (stress…
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