Sucrose Is Insoluble In Organic Solvents

Instead of approximately 28 mL of water being added, 140 mL of water was added. To correctly identify the compound, it was concentrated with nitrogen while the container was placed in a boiling water bath. After being concentrated enough, the experiment was able to continue. To confirm that the unknown was acetanilide, a comparison of the melting points between the acetanilide, phenacetin and the unknown was performed which led to confirming that the unknown was

Aspirin, Caffeine and Salicylamide were extracted from an over-the-counter pain reliever (BC Powder). These components were separated by manipulating their solubilities by adjusting the acidity and basicity of the solution. By doing this, the three components were forced into conjugate acid (or base) forms, causing selective solubility in either an aqueous or organic solvent. These layers were then separated by use of a separation funnel. Once separated, the components extracted were characterized by measuring the melting point and performing a TLC analysis. Also, the recovered aspirin from the first part of the experiment was recrystallized and compared to that of the

Separation and Purification of the Components of an Analgesic Tablet. Cora Bruno, Lab Section E. Aspirin, Caffeine and Acetaminophen were separated from four analgesic tablets of Excedrin using extraction techniques. 5% wt/vol NaHCO3, 4M HCL, ethyl acetate and deionized water were used to separate the three active components. MgSO4 was used to dry each extraction. Aspirin was isolated using a hot water bath and weighed to determine the percent theoretical recovery and the actual percent recovery of aspirin. After separation, Aspirin (ASA), Caffeine (CAF), and Acetaminophen (ACE) were purified and identified using Thin Layer Chromatography (TLC). Standards and purified ASA, CAF, and ACE were spotted on the silica gel (stationary phase) of the

In experiment two, the drug Panacetin was separated by a series of chemical reactions into its three components: sucrose, aspirin, and an unknown active ingredient, either acetanilide or phenacetin. The purpose of this lab was to determine what percentages of each component is present in the pain-killer. The initial step was to dissolve Panacetin in dichloromethane. However, sucrose is insoluble in dichloromethane because organic molecules are soluble in organic solvents, and dichloromethane is an inorganic solvent, so only aspirin and the unknown dissolved. By using gravity filtration, sucrose was filtered from the solution and 0.30g of solid was collected.

The purpose of experiment three was to identify the unknown component in the drug Panacetin. The use of physical properties can help identify unknown compounds and estimate the degree of their purities. In this experiment, solubility in boiling water and melting point were used to determine if the unknown was acetanilide or phenacetin. Since both compounds are soluble in boiling water and insoluble in cold water, recrystallization was used to remove any impurities from the solid.

From the graph, R2 can be extrapolated from the y-axis and the corresponding value on the x-axis (the point of intersection on the curve) gives the concentration of the unknown solution.

Panacetin is an analgesic (pain reducing) and antipyretic (fever reducing) drug that is sold in drug stores. However, there is a suspicion that this bottle may be counterfeit, not containing the chemicals that it should. Panacetin should be made up of about 50 percent of the unknown component that we previously separated out of Panacetin for testing. We suspect that this unknown compound is either acetanilide or phenacetin, both of which can be toxic to humans. It is very important that this component is

The aspirin was synthesized when it was placed in a cold bath. Purification was necessary to remove any unreacted salicylic acid and acetic anhydride as well as the acetic product and phosphoric acid. Acetic acid and phosphoric acid are water soluble so they were removed by

Salicylic acid was esterfied using acetic acid and sulfuric acid acting as a catalyst to produce acetylsalicylic acid and acetic acid. The phenol group that will attack the carbonyl carbon of the acetic anhydride is the –OH group that is directly attached to the benzene since it is more basic than the –OH group attached to the carbonyl group. This method of forming acetylsalicylic acid is an esterification reaction. Since this esterification reaction is not spontaneous, sulfuric acid was used as a catalyst to initiate the reaction. Sulfuric acid serves as the acid catalyst since its conjugate base is a strong deprotonating group that is necessary in order for this reaction to be reversible. The need for the strong conjugate base is the reason why other strong acids such as HCl is not used since its conjugate base Cl- is very weak compared to HSO3-. After the reaction was complete some unreacted acetic anhydride and salicylic acid was still be present in

The aspirin starts begins to dissolve by the enzymes and are soaked in while traveling down to the stomach. They then are distributed to the areas that need the pain relief.

The purpose of this lab is to investigate the composition of a compound suspected to be Panacetin, a type of pain-killer. Panacetin is typically made up of sucrose, aspirin, and acetaminophen, but the third component in this experiment is unknown. The unknown component is suspected to be a chemical relative of acetaminophen, either acetanilide or phenacetin. Using techniques such as extraction, evaporation, and filtration, the three components will be isolated based on their solubilities and acid-base properties. Then, the percent composition of Panacetin can be deduced based on the masses of the three dried components. The

Sucrose is insoluble in the organic solvent dichloromethane (CH2 Cl2). Aspirin, acetanilide, and phenacetin are soluble in dichloromethane but relatively soluble in water. Aspirin reacts with bases such as sodium bicarbonate to form a salt, sodium acetylsalicylate, which is insoluble in water. Acetanilide and phenacetin are not converted into salts by sodium bicarbonate.

Not all of the Panacetin would be dissolved completely, instead you would end up affecting the % yield, % purity, % composition of each component, and % recovery.

Industrial production of Aspirin is dependent on the company producing the drug; however the general method of production is known as slugging or dry-granulation. In this method, corn starch is mixed with pure water and is then heated and

The purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding Iron (III) chloride to the product.