Summary Of Functional Network Connectivity

Autism spectrum disorders are a class of developmental disorders that impair social skills, behavior, and communication (Center for Disease Control). ASDs are considered ‘spectrum’ disorders because each patient has a unique experience in the nature and severity of their symptoms (Center for Disease Control). Under the umbrella of ASDs, there are three types of disorders, including Autistic disorder, Asperger Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified (Center for Disease Control). Autistic disorder is the most severe of the three, and patients exhibit significant problems with language, communication, and behavior (Center for Disease Control). Furthermore, people with Autistic disorder often have some intellectual impairment (Center for Disease Control). Asperger Syndrome is a milder form of autistic disorder where patients have some developmental delays, but their language and intellect are not affected (Center for Disease Control). The mildest of the ASDs is the pervasive developmental disorder. These patients usually don’t meet all of the criteria for autistic disorder, but do show some signs of social and communication problems (Center for Disease Control). The number of children diagnosed with ASD is growing, and currently 1 in 88 children fall somewhere on the spectrum (Mari-Bauset et al., 2013). Boys are four times more likely than girls to have autism, and while the exact cause of these disorders is unknown, both genetic and

Autism spectrum disorder (ASD) may be a disorder in the brain, caused by genetic, environmental or neural levels. Autism effects data processing in the brain by alerting how nerve cells and their synapses connect and organize; how this occurs not understand. (Johnson.2004)

According to Kids Health (2014), “children with Autism have difference in the way their brains develop and process information”. For example, “language delay, trouble communicating with their brains, perform certain unusual or repetitive behaviors, or have difficulties learning in school” (p. 1).

Autism is the main form of autism spectrum disorders (ASD). Autism is a developmental disorder that is manifested in problems with communication, impairment of social functioning, and repetitive behaviours. According to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), ASD diagnoses must meet four different areas of criteria. There are three symptoms of "deficits in social communication and interaction across contexts," four symptoms of "restricted, repetitive patterns of behaviour, interests, or activities," "symptoms must be present in early childhood," and the symptoms must "together limit and impair everyday functioning" (Carpenter, 2013). There are many theoretical positions on the causes of autism spectrum disorders. Some of which have been discounted by empirical studies that have been researched and performed.

Autism is characterized as a neurodevelopmental disorder that affects social interactions, nonverbal and verbal communication, and restricted and repetitive behavior. On a global scale, autism was estimated to affect 21.7 million people in 2013, and the number continues to rise as time persists. Children are often diagnosed while they are infants, usually in the first two years of life, when parents notice odd behaviors such as assembling toys or stacking of objects. It is not yet well understood how autism occurs, but we do know that autism affects information processing in the brain by changing the way nerve cells and their synapses connect and organize. Autism is one of the three disorders that make up the Autism Spectrum, the second is

“A wealth of new brain research is lifting the veil” on Autism and revealing its effects on a child`s mind (Cray and Wallis 43). Neuroscientist Eric Courchesne at Children`s Hospital of San Diego revealed that “while children with autism are born with ordinary-size brains, they experience a rapid expansion by age two” (Cray and Wallis 45). Much of this growth is due to the excessive amount of white matter, the nerve fibers that link different areas of the brain. The abundance of white matter has led doctors to believe Autism to be a problem with the way the brain is wired. Marcel Just, director of Carnegie Mellon`s Center for Cognitive Brain Imaging in Pittsburgh, Pennsylvania, wrote that “there is a lack of synchronization” between the different areas of the brain (Cray and Wallis 46). Local areas of the brain, such as the frontal lobes and the amygdala, are over-connected while links between more distant regions, such as the right and left hemispheres, are poorly connected. One area of the Autistic brain that is enlarged is the amygdala. The amygdala`s job is to assess threats in the environment or in emotional and social behavior. It could be enlarged due to the fact that autistic children maintain a high level of anxiety when having to relate to other people. Another enlarged area of the autistic brain is the hippocampus, an area vital to memory. Doctors believe the hippocampus is enlarged because an autistic child relies on memory to process and interpret situations that most people interpret in a different area of the brain. Researchers have also discovered that autistic brains have chronic inflammation. Amidst these issues Autistic people have learned to adapt and use their brains in unusual ways. For example, they memorize the alphabet in

In a research project monitoring the brain waves of a child observing a task and completing a task, it was found that the two sets of brain waves were almost identical. However, when testing an autistic child, it was found that two different sets of brain waves were created. This research suggests that autistic children have a lower number of mirror neurons, which would help explain their deficiency in social interaction, imitation, and empathy.

Park, H. R., Lee, J. M., Moon, H. E., Lee, D. S., Kim, B.-N., Kim, J., … Paek, S. H. (2016). A Short Review on the Current Understanding of Autism Spectrum Disorders. Experimental Neurobiology, 25(1), 1–13. http://doi.org/10.5607/en.2016.25.1.1

If we look at the anatomical parts of the brain, we can notice differences in autistic children’s brain. According to Just, Cherkassky, Keller, Kana, and Minshew (2007), when autistic group was compared to control group, the functional connectivity was lower for the autistic participants between frontal and parietal areas, relevant parts of corpus callosum were smaller in cross sectional area and the size of the genu of the corpus callosum was associated with the functional connectivity of frontal-parietal. Applied Behavioral Analysis is one of the most widely used interventions working with children that have autism. ABA intervention is bases of the behavioral therapy that was introduced by B.F.Skinner, a spokesperson for

Chapter 1 focuses on autism, Pervasive Developmental Disorders (PDDs) and other Autistic Spectrum Disorders (ASDs). Described in 1943 by Dr. Leo Kanner, autism (also known as autistic disorder, childhood autism, or infantile disorder) is one of the PDDs along with Rett's disorder, Childhood Disintegrative Disorder (CDD) referred to as Heller's syndrome, Asperger disorder, and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). Rett's is a rare genetic abnormality affecting brain development in girls. There are treatments available, but there is no known cure. Asperger disorder affects an individual's ability to socialize and communicate effectively. Individuals with Asperger disorder may be socially awkward and have a compulsive

The study demonstrates that functional connectivity profiles from functional magnetic resonance imaging studies can accurately and consistently identify individual subjects between scan sessions and also task and rest conditions. Data from 126 subjects of six fMRI sessions provided by the Human Connectome Project were used for the primary data set. Each subject was scanned over 2 days (3 sessions each day): consisting of a resting-state session, a working-memory task, and a motor task on the first day; costing a resting-state session, a language task, and an emotion task on the second day. Functional connectivity was mapped in a functional brain atlas consisting of 268 nodes covering the brain. Identification was performed across pairs of scans comparing

Neurological disorders are complex in nature and often the least understood. Given the recent boom in imaging technology and other diagnostic methods, it is now possible to see more clearly into the scope of neurological development and accurately determine the etiology of these diseases. One of such disorders is Autism; a multifactorial condition impairing normal brain development. It affects many aspects of development, including social behavior, cognitive ability and communication skills1 and is commonly diagnosed in children before the age of three1. The symptoms of this condition can vary greatly between individuals; hence its classification as a spectrum disorder. Asperger syndrome, Rett syndrome and pervasive

Symptoms typically are apparent before children turn 3 years old. (7). When individuals are born as an identical twin or have first degree relatives who have autism, they are automatically at a higher risk for developing it themselves. Other risk factors include immune dysregulation, altered short chain fatty acids, genetic mutations involving the metabolism of vitamin D, infections, teratogens, or antibodies maternally. For every 68 boys who are born, 1 will likely have autism, as boys are about five times more likely to present with autism than girls are. (3). When the brains of patients with Autism Spectrum Disorder are studied and compared with those who do not have the disorder, there are obvious differences. In the Autism Spectrum Disorder brain, there are alterations to the striatal circuits, a dysfunction in canonical neural circuits, and an abnormal basal ganglion connectivity. These striatal dysfunctions of the brain are evidence as to why abnormal behaviors occur in autistic patients (repetitive grooming, stereotypic motor routines, and deficits in social interaction and decision-making). There may even be evidence that links genetics to these specific neural circuits. (8). When MRI’s are taken on young autistic patients, the hyperplasia of their cerebral cortex can often be seen. Because the frontal and temporal lobes are important for social functioning and language development, these anatomical anomalies are likely to underlie the pathophysiology of autism.

Stated previously autism is neurodevelopmental disorder that affects the brain by disrupting social and cognitive functions. For the best non-invasive way to see the affects on the brain is an MRI machine. Evidence shows that an increase in size of the overall brain is one of the primary signs; more specific the parieto-temporal lobe, and enlargement of the cerebellar hemisphere volumes was a common sign of Autism. Also abnormalities in the limbic system and cerebellum contribute the pathophysiology of autism. These changes are most related to the abnormal brain development in early life. To simplify things, autistic children have excessive amount of nerve fibers, but they do not work well and there for communicate between fiber is non-existent. Because of these large amounts of fiber explains the overall enlargement of the brain. Even though at birth the brain is normal or smaller than normal size, it goes through a period of rapid growth between six to fourteen

The neurodevelopmental disorders, according to the DSM 5, are a group of conditions with onset in the developmental period. The disorders typically manifest early in development, often before the child enters grade school, and are characterized by developmental deficits that produce impairments of personal, social, academic, or occupational functioning. Autism spectrum disorder (ASD) is newly classified as such; it was once classified as “Asperger’s Syndrome.” ASD is a severe neurodevelopmental impairment. The disorder limits the functioning capabilities of children and their capacity to communicate as well as interact with others. ASD effects how children perceive the world around them; socializing with others happens to be the most vital piece of development. Onset for ASD can occur as early as infancy, some children, however, may develop normal and then begin to suddenly withdraw and become unusually aggressive with those around them, they also begin to lose vocabulary and language skills they’ve once had. Other medical conditions may be comorbid with ASD; for example, epilepsy, intellectual and structural language disorders, mental disorders, sleep disorders, and avoidant-restrictive food intake disorders, (DSM 5, pg. 59).