Summary Of Rivaroxaban

The need for evolving guidelines has stemmed from groundbreaking research on the topic of hypertension and antihypertensive medications. In the last two decades, there has been a change

I would like to express many thanks for my advisor Daryl Sieg for all of the support. I would also like to thank Dr. Klug for her guidance in the statistical aspect of this paper. Thank you to Allison Frank at the coagulation clinic in Fargo for taking the time to discuss my paper with me. Her view on these medications was very beneficial.

The European Society of Cardiology guidelines recommend that if the patient has a CHADS2 score of >2, oral anticoagulation therapy such as warfarin, dabagitran, or rivaroxaban should be prescribed. If the CHADS2 score is 0-1, other stroke risk modifiers could be considered such as

Current medications include Ultracet 37.5/325 mg 1 tablet twice daily, Lodine 400 mg 1 tablet twice daily (on hold until 04/2017) and Zanaflex 4 mg twice a day. Of note, last urine drug screen was obtained on 01/19/16. Patient has allergy to Penicillin and Lyrica was reported to cause weight gain.

There was total of 76 patients with AF receiving Dabigatran during the study period. The mean age was 67.9 ±1.5 years (range 29 - 98 years), males (52.6%, 66.3 ±1.7 years), and females (47.4%, 69.6 ±1.1years). The age group stratifications revealed the highest age group was those between 61 to 80 years (60.5%). The majority (73.7%) was ≤75 years, [Table 1]. 76.3% used Dabigatran 150 mg. The mean CHA2DS2, CHA2DS2-VASc, HAS-BLED score were 2.38 ±1.46, 3.54 ±1.82, and 3.46 ±1.205, respectively, [Table 2].

Based on the search and evidence, I would recommend the patient to use Lisinopril because it is cheaper compared to the other Ace-inhibitor because the patient doesn’t have insurance at least he can afford a medication.8. The recommended dosage for the patient would be taking lisinopril 5mg orally once daily for 2 days within 24 hours of acute myocardial infarction, then 10 mg orally once daily for at least 6 weeks. 8 Taking ACE-inhibitors have shown positive aspects for diabetes patients which can help improve their disease

The administration of drug Rituximab is in intravenous (IV) infusion form and diphenhydramine and acetaminophen should be given before each infusion. Rituximab will be supply in 100 mg/mL or 100 mg/mL single dose vials. The first infusion dose is 400 mg/m2 intravenously at a rate of 50 mg/hr. The maximum infusion dose should not exceed 400 mg/hr. The early treatment will be weekly basis for four weeks (Product Monograph, 2014) at initial rate of 100 mg/hr; and should not

Lisinopril is used to treat hypertension as well heart failure. Lisinopril is not occasionally used to treat postmyocardial infarction, migraine, diabetic retinopathy and nephropathy, and proteinuria. These conditions have not been approved by the FDA to be treated with Lisinopril. Pregnant women should not use Lisinopril. Injury or death may be side effects that an unborn baby will experience if the medication is taken by a pregnant woman in the second or third trimester. Birth control needs to be taken when a patient is taking Lisinopril. The dosage recommended for patients treating hypertension is 5-10 mg once a day. A maintenance dose of 20 to 40 mg is also suggested and the maximum dose to treat hypertension is 80 mg. Patients that are

As the proportions of the aging U.S. population increases, more people are susceptible to venous thromboembolism (VTE) that often contribute to prolonged hospitalization, health complications, disability, poor quality of life, and premature death. This increase in VTE-related deaths and health complications has threatened the health and the economy of the U.S. society. Health care professionals need to make a better decision in preventing VTE, especially with the rise of new oral anticoagulants. Therefore, this integrative review discusses the effectiveness of Rivaroxaban, a new oral anticoagulant, versus Enoxaparin, a standard therapy, in preventing the occurrence of VTE thus reducing the nation’s

By reviewing the medication list it was noted that there were two anti- hypertension pills prescribed: metoprolol and lisinopril. They

As ceftobiprole is primarily cleared by the kidneys, dose adjustment is recommended in both moderate to severe renal impairment and augmented renal function (creatinine clearance [CLcr] >150 mL/min), see Table 2.

The causes of premature discontinuation are adverse events, consent withdrawal, and loss to follow-up. Patient demographics are reported as well, and the authors provide a useful table with basic patient information including age, weight, gender, and renal function. There are some very miniscule differences in groups for both studies, but these differences should not affect the results because of randomization. The trial results are reported in percentages of event occurrence in a population. While these are useful in understanding the frequency of harmful effects or successful treatment, a surrogate measurement and use of INR measurements may provide a better idea of the extent of safety or efficacy. In the Acute DVT Study, the primary efficacy endpoint occurred in 2.1% of rivaroxaban patients and in 3.0% of standard therapy patients (Hazard ratio 0.68; 95% CI 0.44 to 1.04; P<0.001 for non-inferiority with a one-sided test, and P = 0.08 for superiority with a two-sided test). The principal safety endpoint of clinically significant bleeding occurred in 8.1% of rivaroxaban patients and in 8.1% of standard therapy patients (hazard ratio with rivaroxaban 0.97; 95% CI 0.76 to 1.22; P =

The patient with systolic ventricular dysfunction should be started on an ACEI and a diuretic. The patient would need to start on the lowest dose possible and titrate up as needed. According to Burchum, Captopril is an ACEI that is indicated for use in heart failure, the initial daily dose should be 6.25mg three times a day (521) and hydrochlorothiazide, a mild thiazide diuretic, should be given at 12.5mg a day (453). The patient would be started on these two medication with instructions on how to take both medications. With eh Captopril, the patient would be instructed to take the medication three times a day with water. They would be told that the Captopril may cause a cough, but that can be a normal side effect. If the cough is unbearable

Warfarin is an anticoagulation that is metabolized in the liver and removed through the kidneys. The proper metabolism of his warfarin is being inhibited by the cimetidine. The effect of warfarin is increased due to the interaction between these two medications. According to Miller (2010), wafarin is a drug that needs to be carefully considered for a patient in terms of interactions. A second issue entails issues pertaining to his signs of bleeding and indication of slow clotting. The patient is having epistaxis, ecchymosis, and an increased international normalized ratio (INR). The normal INR range of warfarin is 2.0-3.0. According to Barta, Nutescu, and Johnson (2015), the patient needs to remain in the accepted range for as long as possible which indicates a stable level. The laboratory results indicated an elevated INR of 4.8. This indicates he is at risk for bleeding due to the rate that his blood is clotting. A third problem pertains to his abnormal digoxin level of 1.6 ng/ml. digoxin is an antiarrhythmic that is metabolized in the stomach and liver. The normal range for this medication is 0.5 to 0.8ng/ml. According to Niemeijer et al. (2015), digoxin can result in sudden death and must be carefully

According to Medscape, the 2013 updated JNC 8 guidelines recommend the first line of pharmaceutical treatment with combination therapy of thiazide-type diuretics along with angiotensin converting enzyme inhibitors (ACE), angiotensin receptor blockers (ARB), or calcium channel blockers (CCB).